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  • 1995-1999  (2)
  • 1935-1939
  • 1995  (2)
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  • 1995-1999  (2)
  • 1935-1939
Year
  • 1
    ISSN: 1615-5947
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We developed a theoretic model of arterial stenosis to study the relationship between perfusion pressure and regional hemodynamics in stenotic infrainguinal vein grafts in an attempt to identify grafts at high risk for failure. Our model was based on the concept of energy and mass conservation of the flowing blood. We used the modified Bernoulli equation (ΔP=4ΔV2) to calculate the maximum possible intrastenotic peak systolic velocity (PSV) from the systolic blood pressure. PSV was measured by means of duplex ultrasonography in infrainguinal bypasses up to the time of revision (nine grafts) or spontaneous thrombosis (two grafts). We related arm systolic blood pressure, intrastenotic PSV, and prestenotic PSV obtained from duplex examinations conducted prior to graft thrombosis or revision and applied our model to these stenotic vein grafts. Intrastenotic PSV was consistently lower than maximum PSV predicted from the Bernoulli equation. The highest measured intrastenotic PSV of 600 cm/sec would require a minimum perfusion pressure of 144 mm Hg. The lowest measured PSV (20 cm/sec) was considered the minimum “thrombotic threshold velocity.” This model predicts that for parabolic profile flow in an 80% diameter-reducing axisymmetric stenosis (96% cross-sectional area reduction), a prestenotic PSV of 20 cm/sec would produce an intrastenotic PSV of 500 cm/sec requiring the equivalent potential energy of 100 mm Hg systolic blood pressure. Our theory implies that in patients with nocturnal hypotension thrombosis of stenotic vein grafts may occur.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1615-5947
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During a 62-month period, carbon dioxide was used to supplement or completely replace iodinated contrast agents in performing 27 transluminal angioplasties in 26 patients. The arterial segments addressed included the following: renal in two cases, iliac in five, femoral/popliteal in 15, infrapopliteal in two, and combined in three. Indications for intervention included lower extremity gangrene in 11 cases, ischemic ulceration in 10, rest pain in three, claudication in one, and ischemic nephropathy in two. Contraindications to iodinated contrast agents included renal insufficiency resulting from diabetes (n = 20) or ischemic nephropathy (n = 2) and congestive heart failure (n = 4). Eight procedures used carbon dioxide as the sole contrast agent, whereas 19 required supplementation of carbon dioxide with a mean of 39 ml of nonionic contrast medium. Technical success was achieved in 25 procedures with significant hemodynamic improvement in 20 patients. Complications included transient deterioration in renal function in two patients and myocardial infarctions in two. At 30 days 18 patients had demonstrated significant clinical improvement. Patients at high risk for iodinated contrast-related complications may undergo transluminal angioplasty using carbon dioxide/digital subtraction arteriography to reduce or eliminate the need for iodinated contrast agents.
    Type of Medium: Electronic Resource
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