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  • Chemistry  (4)
  • Cell volume regulation  (1)
  • Essential hypertension
  • Essentielle Hypertonie
  • General Chemistry
  • Human
  • Lens
  • Organic Chemistry
  • Renovascular hypertension
  • 1990-1994  (6)
  • 1985-1989
  • 1980-1984
  • 1994  (6)
Document type
Keywords
Publisher
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  • 1990-1994  (6)
  • 1985-1989
  • 1980-1984
Year
  • 1
    Electronic Resource
    Electronic Resource
    Morning versus evening administration of nifedipine gastrointestinal therapeutic system in the management of essential hypertension (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 864-869 
    Details
    ISSN: 1432-1440
    Keywords: Nifedipine gastrointestinal therapeutic system ; Essential hypertension ; Ambulatory blood pressure measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nifedipine gastrointestinal therapeutic system (GITS) is a recently developed controlled-release formulation for once-a-day dosing. We evaluated the influence of morning versus evening administration of the drug in a randomized double-blind cross-over study including 15 essential hypertensives. Five patients had to be excluded from blood pressure analysis because of noncompliance (three cases) or intolerable side effects (two cases). To assess the exact duration of the antihypertensive efficacy noninvasive automatic ambulatory blood pressure monitoring was performed. After a placebo period patients were given 30 mg nifedipine GITS either at 1000 or 2200 hours. Twenty-four-hour systolic and diastolic blood pressure profiles documented a sustained antihypertensive effect of both nifedipine regimens throughout the whole period without affecting the circadian rhythm. Statistical analysis revealed no significant difference between morning and evening administration. Two patients stopped their medication because of intolerable side effects (fatigue and muscle cramps, respectively). Two more cases suffered from mild reversible headache which provoked no discontinuation of the drug. In conclusion our results document a sustained antihypertensive efficacy of 30 mg nifedipine GITS in patients with moderate essential hypertension. Time of administration has no impact on day- and nighttime blood pressure control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190742
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  • 2
    Electronic Resource
    Electronic Resource
    Hypertonic saline infusion induces activation of the lymphocyte Na+/H+ antiport and cytosolic alkalinization in healthy human subjects (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 817-821 
    Details
    ISSN: 1432-1440
    Keywords: Cell volume regulation ; Hypertonicity ; Lymphocytes ; Na+/H+ antiport ; Saline infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Na+/H+ antiport is a membrane transport protein that extrudes intracellular protons in exchange for extracellular sodium. Some details of its physiological and pathophysiological role remain poorly defined. Experimental evidence suggests that the antiporter is involved in the regulation of cell volume. In the present study, we therefore investigated the activity of the lymphocyte Na+/H+ antiport in nine healthy volunteers following acute hypertonic (2.5%) saline infusion (4 mmol NaCl/kg over 120 min). Antiport activity was measured after acidifying the cells with Na+ propionate (5–40 mM) using the fluorescent dye bis-carboxyethyl carboxyfluorescein. Hypertonic saline induced significant increases in plasma osmolality (308.4±2.3 vs. 293.5±2.7 mOsm/kg; P〈0.01), serum Na+ (150.8±3.7 vs. 138.9±0.5 mmol/kg; P〈0.01), and Cl− concentrations (118.0±3.9 vs. 101.1±1.0 mmol/kg; P〈0.01). Extracellular hypertonicity was followed by a stimulated activity of the lymphocyte Na+/H+ antiport with an increase in the apparent V max values from 2.44±0.16 to 3.27±0.34 10−3 s−1 (P〈0.01) and a slight rise in pK from 6.81±0.03 to 6.87±0.03 (P〈0.05) after hypertonic saline. In addition to antiport activation, cytosolic alkalinization was observed with cytosolic pH values averaging 6.90±0.02 before and 6.99±0.02 (P〈0.01) after hypertonic saline. Our results show for the first time that acute extracellular hypertonicity in man due to hypertonic NaCl loading is associated with a stimulated lymphocyte Na+/H+ antiport activity and cytosolic alkalinization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190734
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  • 3
    Electronic Resource
    Electronic Resource
    On the para/ortho product ratio of phenol and anisole hydroxylation over titanium silicalite-1Dedicated to Professor Dr. Manfred Baerns on occasion of his 60th birthday (1994)
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 17 (1994), S. 348-353 
    Details
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Titanium silicalite-1 samples of different particle size are synthesised and characterised by X-ray diffraction (XRD), photoelectron spectroscopy (XPS), diffuse reflectance spectroscopy (DRS), Raman and infrared spectroscopy. Size histograms are taken from transmission electron micrographs. Temporal changes of activity and selectivity for the hydroxylation of phenol and anisole are monitored. It is postulated that the p/o product ratios are due to the greater chemisorption of the ortho molecule.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ceat.270170509
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  • 4
    Electronic Resource
    Electronic Resource
    F. W. McLafferty, F. Turecek. Interpretation of mass spectra. Fourth edition (1993). University Science Books, Mill Valley, California (1994)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 23 (1994), S. 379-379 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200230614
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  • 5
    Electronic Resource
    Electronic Resource
    Rühreinrichtungen in Schneckendosiergeräten  -  Wirkung und AuslegungsstrategieNach einem Vortrag der Verfasser auf der Sitzung des GVC-Ausschusses „Agglomerationstechnik“ am 3.5. 1993 in Goslar sowie teilweiser Auszug der Dissertation von H. Wolfschaffner. (1994)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 163-171 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Stirring Devices in Screw Metering Equipment - Action and Design Strategy. The accurarcy of metering by screw dosage equipment with or without gravimetric control depends primarily on the flow of material to the discharging screw. In the case of cohesive solids, stirring devices are generally required to prevent bridging. Experimental observations show that flow conditions correlate directly with the intensity of stirring. Mass flow in the metering container and hence optimum constancy of metering are attainable only from certain stirring efficiencies upwards. Cases of interference to metering due to poor flow of solids can be explained and overcome by modified dimensioning. The effects of the principal parameters - geometry and speed of rotation of the stirrer - are studied with the aid of two stirrer configurations - viz. overhead and concentric. Straightforward model calculations provide a mathematical method of estimation for optimum and reliable stirrer dimensioning also applicable to strongly cohesive solids.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330660204
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  • 6
    Electronic Resource
    Electronic Resource
    Gas chromatographic separation of polychlorinated biphenyls on a new apolar capillary column (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 851-858 
    Details
    ISSN: 0935-6304
    Keywords: High resolution gas chromatography ; Chlorinated hydrocarbons ; Polychlorinated biphenyls ; PCB indicator congeners ; Coelution ; Toxic PCB congeners ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Eighty one polychlorinated biphenyls (PCBs) and nineteen chlorinated pesticide standards have been analyzed on a newly developed apolar high resolution gas chromatography (HRGC) column. Emphasis was placed on the determination of PCB indicator congeners which are part of national regulations, and of toxic coplanar PCB congeners.The new column enables almost unambiguous quantification of the PCB indicator congeners (PCB 138 can be separated from both PCB 163 and PCB 164; PCB 28 and PCB 31 were also separated and no coelution was observed for PCB 52, PCB 118, and PCB 180). The new column furnished better results than CP-Sil 8 for the analysis of PCB indicator congeners in a sample of seal blubber.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240171208
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