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  • Ambulatory blood pressure measurement  (1)
  • Apo B  (1)
  • Essential hypertension  (1)
  • Springer  (2)
  • American Heart Association (AHA)
  • Nature Publishing Group (NPG)
  • Oxford University Press
  • PANGAEA
  • 2015-2019
  • 2010-2014
  • 1990-1994  (2)
  • 1975-1979
  • 2013
  • 1994  (2)
  • 1
    ISSN: 1432-1440
    Keywords: Nifedipine gastrointestinal therapeutic system ; Essential hypertension ; Ambulatory blood pressure measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nifedipine gastrointestinal therapeutic system (GITS) is a recently developed controlled-release formulation for once-a-day dosing. We evaluated the influence of morning versus evening administration of the drug in a randomized double-blind cross-over study including 15 essential hypertensives. Five patients had to be excluded from blood pressure analysis because of noncompliance (three cases) or intolerable side effects (two cases). To assess the exact duration of the antihypertensive efficacy noninvasive automatic ambulatory blood pressure monitoring was performed. After a placebo period patients were given 30 mg nifedipine GITS either at 1000 or 2200 hours. Twenty-four-hour systolic and diastolic blood pressure profiles documented a sustained antihypertensive effect of both nifedipine regimens throughout the whole period without affecting the circadian rhythm. Statistical analysis revealed no significant difference between morning and evening administration. Two patients stopped their medication because of intolerable side effects (fatigue and muscle cramps, respectively). Two more cases suffered from mild reversible headache which provoked no discontinuation of the drug. In conclusion our results document a sustained antihypertensive efficacy of 30 mg nifedipine GITS in patients with moderate essential hypertension. Time of administration has no impact on day- and nighttime blood pressure control.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 72 (1994), S. 944-950 
    ISSN: 1432-1440
    Keywords: Hypertension ; Low density lipoprotein ; Apo B ; Cholesterol ; Very low density lipoprotein ; Triglycerides ; Lipoprotein (a)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P ≤ 0.001), Apo B serum levels (P ≤ 0.001), serum triglyceride levels (P ≤ 0.05) and VLDL serum levels (P ≤ 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.
    Type of Medium: Electronic Resource
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