ISSN:
1573-1111
Keywords:
Cyclodextrin
;
DSS
;
inclusion complex
;
NMR
;
TMS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Tetramethylsilane (TMS) can be included by β-cyclodextrin (β-CD), and sodium 2,2-dimethylsilapentane-5-sulphonate (DSS) can form inclusion complexes with β- and γ-CD. The NMR chemical shifts are changed considerably as a result of the strong interaction between CD and the guest compound in the inclusion complexes. A downfield shift of as much as 0.63 ppm shift downfield has been observed for the protons of external TMS in CD aqueous solution. In view of this, the question arises of whether TMS and DSS can be used as internal references. DSS in D2O is suggested as an external reference for aqueous cyclodextrin solution in NMR measurements.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00706472
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