ISSN:
1432-1440
Keywords:
Apolipoprotein E
;
Atherosclerosis
;
Familial dysbetalipoproteinemia
;
Genetic polymorphism
;
Type III hyperlipoproteinemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The clinical and biochemical characteristics of type III hyperlipoproteinemia are described in 64 patients (35 males and 29 females). Homozygosity for apolipoprotein E2, the presence of an abnormally cholesterol-rich very low density lipoprotein fraction (β-VLDL) and an elevated ratio of very low density lipoprotein cholesterol to plasma triglycerides (〉0.3; normal ratio about 0.2) were the basis for the diagnosis. Mean serum cholesterol and triglyceride concentrations at the first visit in the clinic were 426 ± 221 and 719 ±996 mg/dl, respectively. The mean age at diagnosis of the disorder was 49 years in males and 53 years in females. There was a high prevalence of obesity (72%), xanthomas (42%), and atherosclerosis (39%), especially peripheral vascular disease (31%). Early and correct diagnosis of this familial lipoprotein disorder seems necessary because of the prompt and beneficial response to therapeutic interventions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00186624
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