ISSN:
1434-4726
Keywords:
Pediatric thyroid neoplasms
;
Spindle epithelial tumor
;
Thymoma
;
Ectopic thymus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract An intrathyroid primary epithelial spindle-cell tumor with mucous cysts is described in a 9-year-old child. Histologically, this well-circumscribed tumor exhibited a nodular pattern, a prominent spindle cell component with minimal pleomorphism, and well-differentiated mucinous glands within fibrous bands. The spindle cells demonstrated diffuse immunopositivity for cytokeratin and vimentin. Electron microscopy of tissue sections demonstrated that cells contained bundles of cytoplasmic tonofilaments and numerous desmosomes. The light and electron microscopic features and immunohistochemical profile of this tumor were similar to those of recently described thyroid tumors that have been called “SETTLE” tumors (i.e., spindle epithelial tumor with thymus-like differentiation). These uncommon tumors can be considered intrathyroid thymoblastomas and must be regarded as potentially malignant lesions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00185397
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