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  • 1
    Book
    Book
    Mechanismen biochemischer Temperaturanpassung : ein Vergleich der Enzymeigenschaften bei Crustaceen aus verschiedenen Klimazonen (1992)
    Kiel : Inst. für Meereskunde, Abt. Meereszoologie
    Details Availability
    Keywords: Hochschulschrift ; Krebstiere ; Temperaturanpassung
    Type of Medium: Book
    Pages: 93 S. , Ill., graph. Darst.
    Series Statement: Berichte aus dem Institut für Meereskunde an der Christian-Albrechts-Universität Kiel 226
    Language: German
    Note: Literaturverz. S. 87 - 93 , Zugl.: Kiel, Univ., Diss., 1992
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  • 2
    Electronic Resource
    Electronic Resource
    Bennett, Gerald; Ebrahim, Shah: The Essentials of Health Care of the Elderly : London, Edward Arnold, 1992 (1992)
    Cambridge : Cambridge University Press
    Ageing and society 12 (1992), S. 406-407 
    Details
    ISSN: 0144-686X
    Source: Cambridge Journals Digital Archives
    Topics: Medicine , Sociology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0144686X00005195
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Is there a connection between postsurgical infections after cardiac surgery and the sort of anesthesia used? (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 510-510 
    Details
    ISSN: 1438-8359
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060510
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of angiotensin II and platelet-derived growth factor-induced vascular smooth muscle cell proliferation by calcium entry blockers (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 113-117 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin II ; Diltiazem ; Mitogenic effect ; Nifedipine ; Platelet-derived growth factor ; Vascular smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Structural changes within the blood vessel wall such as hyperplasia and hypertrophy of vascular smooth muscle cells are important factors in the pathogenesis of hypertension. Humoral growth factors such as angiotensin II (AII) and platelet-derived growth factor BB (PDGF-BB) may participate in the remodelling of the blood vessel wall. Whether and by which mechanisms antihypertensive treatment is capable of influencing the structural blood vessel alterations to date remains unclear. In the present study, the effect of nifedipine and diltiazem on AII- and PDGF-BB-induced vascular smooth muscle cell proliferation was examined. Nifedipine and diltiazem at a concentration of 10 μM did not affect baseline DNA synthesis in isolated vascular smooth muscle cells in culture. AII (final concentration 100 nM) and PDGF-BB (50 ng/ml) stimulated DNA synthesis by approximately 9.0- and 4.6-fold, respectively. Both AII- and PDGF-BB-induced DNA synthesis was significantly blunted by diltiazem and nifedipine in a concentration of 10 μM, while no significant influence was seen with concentrations from 10 nM up to 1 μM. In contrast, no significant influence of these drugs could be observed on fetal calf serum 5%-induced DNA synthesis. The findings indicate that calcium antagonists possess antimitogenic potential and that they may thus contribute to the regression of structural changes of the blood vessels associated with hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227350
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  • 5
    Electronic Resource
    Electronic Resource
    Urinary free cortisol versus 17-hydroxycorticosteroids a comparative study of their diagnostic value in Cushing's syndrome (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 545-548 
    Details
    ISSN: 1432-1440
    Keywords: Cushing's syndrome ; Urinary corticosteroids ; diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated the usefulness of the basal urinary 24-h excretion rates of free cortisol versus 17-hydroxycorticosteroids in the diagnosis of Cushing's syndrome. On an outpatient basis, both urinary free cortisol and 17-hydroxycorticosteroids levels were determined in 48 patients with Cushing's syndrome, as well as in 95 obese and 94 healthy control persons of normal weight. Determination of the urinary free cortisol content allowed a clear-cut distinction between the patients with hypercortisolism and the controls, resulting in a sensitivity of 100% and specificity of 98% for the diagnosis of Cushing's syndrome. The diagnostic accuracy of urinary free cortisol was distinctly superior to that of 17-hydroxycorticosteroids, which showed a wide overlap of values between the groups, with a sensitivity of 73% and a specificity of 94%. In conclusion, the measurement of basal urinary free cortisol provided an excellent diagnostic sensitivity and specificity in the assessment of adrenocortical function. This simple and accurate test thus seems to be particularly useful in the outpatient evaluation of patients with suspected Cushing's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184788
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of a high-cholesterol diet on arterial wall thickness and vascular reactivity in young rabbits (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 105-112 
    Details
    ISSN: 1432-1440
    Keywords: Cholesterol diet ; Arterial wall thickness ; Vascular reactivity ; Duplex sonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cholesterol enrichment of arteries may induce biochemical and structural abnormalities in vascular smooth muscle resulting in increased arterial contractile sensitivity. We studied the effects of a high-cholesterol diet on arterial structural properties and vascular reactivity in young rabbits. In vivo measurements of aortic intimal-plus-medial thickness using high resolution ultrasound imaging were obtained before and after 3 weeks of a high-cholesterol diet in 12 rabbits (group 2) and compared to data from 12 animals a cholesterol-free diet fed (group 1). Six rabbits (group 3) were studied before and after a 3-week, high-cholesterol diet and after a subsequent 13-week, cholesterol-free recovery diet. Blood pressure responsiveness to noradrenaline was evaluated before and at the end of each diet period. In groups 2 and 3, high dietary cholesterol caused an increase in intimal-plus-medial thickness from 0.31 mm and 0.33 mm to 0.88 mm and 0.89 mm, respectively (p〈0.001). Plasma cholesterol concentration rose from 0.9 ±0.26 mmol/l to 36.7 ± 8.56 mmol/l. There was no change in group 1. In group 3, intimal-plus-medial thickness remained increased (1.01 mm) following the cholesterol-free recovery diet despite normal plasma cholesterol. Blood pressure responsiveness to noradrenaline was markedly increased after the high-cholesterol diet (p〈0.001) in groups 2 and 3 and after the cholesterol-free recovery diet in group 3 (p〈0.001), and was directly related to intimal-plus-medial thickness (r=0.84;p〈0.001). The data indicate that short-term high dietary cholesterol in the early life of rabbits causes long-lasting biochemical and structural arterial wall abnormalities, which might not only explain the observed increase in blood pressure responsiveness to noradrenaline, but could also lead to persistent functional vascular smooth muscle alterations. The result may be a predisposition to increased vascular smooth muscle response to high dietary cholesterol in adult life and development of high blood pressure and atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227349
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  • 7
    Electronic Resource
    Electronic Resource
    Distribution and dendritic features of three groups of rat olivocochlear neurons (1992)
    Springer
    Anatomy and embryology 185 (1992), S. 1-16 
    Details
    ISSN: 1432-0568
    Keywords: LOCS ; MOCS ; Auditory brain stem ; Superior olivary complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cholera toxin B subunit conjugated to horseradish peroxidase, and unconjugated cholera toxin B subunit are useful tools for retrograde tract tracing. Unilateral injection of either cholera toxin preparation into the cochlea results in excellent labeling of olivocochlear neurons, as judged by the Golgi-like filling of cell bodies, dendrites, and even axons. By this approach, we have studied the light microscopic cytology and topographic distribution of olivocochlear neurons and counted their numbers in Sprague-Dawley rats. The olivocochlear system of rats can be divided into three subgroups. The lateral olivocochlear system, composed of small cells located exclusively within the ipsilateral lateral superior olive (relative to the test cochlea), and a medial olivocochlear system, composed of large cells bilaterally dispersed within the ventral nucleus of the trapezoid body, conformed to previous topographic descriptions. A third subgroup of approximately 110 large cells, herein termed shell neurons, was labeled by both tracers, but was not well recognized in previous studies. Shell neurons and their dendrites surround the ipsilateral, and to a much lesser extent the contralateral, lateral superior olive. Lateral olivocochlear neurons do not project their dendrites outside the gray matter of the lateral superior olive, while dendrites belonging to shell neurons penetrate into that nucleus as well as into other auditory brain stem nuclei and the surrounding reticular formation. Medial olivocochlear neurons usually project dendrites ventrally into the trapezoid body and are always excluded from the lateral superior olive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213596
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  • 8
    Electronic Resource
    Electronic Resource
    Osteogenesis imperfecta: A clinical study of the first ten years of life (1992)
    Springer
    Calcified tissue international 50 (1992), S. 36-41 
    Details
    ISSN: 1432-0827
    Keywords: O.I. childhood ; Clinical course ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary One hundred twenty-seven children with osteogenesis imperfecta (O.I.) were studied during the first 10 years of life. According to Sillence, 40 patients were assigned to type I, 39 to type III, and 48 to type IV O.I. Centiles for height, weight, and the annual number of fractures could be established for the different types of O.I. The development of the skeletal changes could be documented for the different forms of the disease. At birth, the skeletal changes were significantly more severe in type III than in type IV patients. During the first 10 years of life the number of fractures, extent of skeletal deformities, and growth retardation did not differ between types III and IV. Only fracture nonunion, dentinogenesis imperfecta, and congenital cardiac malformations were more frequent in type III than in type IV. Papillary calcifications of the kidney and kidney stones were diagnosed in 4 type III and 2 type IV patients. Hemihypertrophy of the body developed, in 2 type I patients. Although types III and IV patients suffered from severe short stature, serum insulin-like growth factor (IGF) I was in the normal range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297295
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 569-575 
    Details
    ISSN: 1432-1041
    Keywords: Nitrendipine ; Bisoprolol ; Hypertension ; self-measured blood pressure ; diurnal variation ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, placebo-controlled study the antihypertensive efficacy and tolerability of a single morning dose of either 10 mg bisoprolol (n=26) or 20 mg nitrendipine (n=27) were investigated. Blood pressure was measured by three techniques: (1) Casual blood pressure 24 h after the dose; (2) ambulatory 24-h whole-day monitoring; and (3) self-recorded blood pressure in the morning 24 h after the dose (6–8 a.m.) and in the evening (6–8 p.m.). After 4 weeks of therapy bisoprolol had produced a highly significant reduction in blood pressure as assessed by casual, ambulatory day- and night-time monitoring, and self-measured morning and evening readings. Bisoprolol was significantly more effective than nitrendipine, which did not induce a significant reduction in the ambulatory night-time recordings. Whole-day ambulatory blood pressure profiles showed an antihypertensive effect of bisoprolol throughout the entire 24-h period. 24-h blood pressure curves after nitrendipine demonstrated a markedly shorter duration of action, with no reduction in early morning blood pressure. Adverse effects and tolerability of the two drugs were comparable. The average changes in systolic and diastolic blood pressure after bisoprolol and nitrendipine in 2-h periods of ambulatory monitoring (6–8 a.m. and 6–8 p.m.) and self-measured blood pressure (6–8 a.m. and 6–8 p.m.) showed a good agreement between ambulatory and self-measured blood pressure determinations with no significant difference between the methods. The results show that 24 h antihypertensive efficacy was more pronounced for bisoprolol than for nitrendipine at the doses studied. Further, self-measured blood pressures at home were suitable for accurate estimation of the 12-h and 24-h antihypertensive efficacy of the two drugs. The methodological findings of this study have important implications for further pharmacological trials investigating the duration of action of antihypertensive drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265917
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibition of cyclooxygenase attenuates baroreceptor function and increases the pressor response to norepinephrine in man (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 681-683 
    Details
    ISSN: 1432-1041
    Keywords: Indomethacin ; Baroreceptor function ; prostaglandins ; haemodynamics ; norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The possible influence of prostaglandins on baroreceptor function in man has been investigated. Baroreceptor reflex was activated by intravenous infusion of norepinephrine and the pressor response was measured, both before and after administration of indomethacin. Resting blood pressure remained unchanged after indomethacin while resting heart rate was significantly decreased as compared to placebo and the norepinephrine-induced rise in mean arterial blood pressure was significantly more pronounced. The baroreceptor-mediated decrease in heart rate tended to be smaller. Baroreceptor sensitivity (Δ heart rate/Δ blood pressure) was significantly reduced by indomethacin to about half of the control value. In addition to attenuation of sensitivity, the findings represent resetting of the baroreceptor setpoint and a more pronounced pressor response to norepinephrine after cyclooxygenase inhibition. Thus, eicosanoids originating via the cyclooxygenase pathway of arachidonate metabolism may modulate the vascular response to adrenergic stimulation and may participate in the regulation of baroreceptor reflex setpoint and sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265937
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