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Serum immunoreactive erythropoietin of children in health and disease (1990)

Eckardt, K. -U. ; Hartmann, W. ; Vetter, U. ; [et al.]

Springer

European journal of pediatrics 149 (1990), S. 459-464

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ISSN: 1432-1076

Keywords: Newborn ; Erythropoiesis ; Anaemia ; Congenital heart disease ; Renal failure ; Arterial oxygen content

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n=97, gestational age 36–43 weeks), in healthy children from birth to adolescence (n=260) and in children with haematological (n=30), renal (n=10) and congenital heart diseases (n=70). In healthy children siEPO levels decreased after birth (geometric mean cord siEPO 35.6 mU/ml with 95% range of 17–56 mU/ml in eutrophic, nondistressed fetuses) and reached lowest values during the first 2 months (geometric mean siEPO 11.5 mU/ml). Thereafter siEPO levels increased slightly and were constant between 2 months and adolescence. The geometric mean siEPO for healthy children after birth was 18.8 mU/ml with 95% range of 7–47 mU/ml. These estimates were not significantly different from normal adult values. In newborns with fetal distress (n=15) cord siEPO was significantly elevated (geometric mean 63.0 mU/ml;P〈0.001). In children with haematological disease, siEPO and Hb concentration were inversely correlated (log siEPO (mU/ml)=4.1−0.20×Hb (g/dl);r=−0.62;P〈0.0005). This relationship was significantly different in children with chronic renal failure (log siEPO (mU/ml)=0.67+0.035×Hb (g/dl);r=0.50;P=0.1). In children with heart disease the geometric mean siEPO was 19.2 mU/ml with 95% range 8–65 mU/ml for cyanotic (SaO2〈94%) and 17.7 mU/ml with 95% range of 12–36 mU/ml for acyanotic patients. In this group siEPO values were inversely correlated to the arterial oxygen content (log siEPO (mU/ml) =1.61−2.04×oxygen content (l/l);r=−0.28;P〈0.02).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01959395

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Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae (1990)

Mannhaupt, Gertrud ; Van Der Linden, Gerard ; Vetter, Irene ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Yeast 6 (1990), S. 353-361

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ISSN: 0749-503X

Keywords: Threonine metabolism ; amino acid biosynthesis ; homologous domains ; chromosome III ; gene organisation ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: The gene encoding theonine synthase (THR4) from the yeast Saccharomyces cerevisiae was cloned by complementation of a thr4 mutant. This gene was also found on a lambda clone (5239) consisting of a fragment of chromosome III inserted in the vector lambda MG3. The THR4 gene encodes a protein of 514 amino acids (M.W. 58 kDa), which has extensive homologies with E. coli threonine synthase (thrC) and B. subtilis threonine synthase. The 5′ flanking region of the gene contains three regulatory sequences. [TGACT(C)] for the general amino acid control (GCN).About 130 bp downstream of the THR4 gene another open reading frame (563 amino acids) is found in the opposite orientation. This may imply that this open reading frame, called CTR86, shares a terminator region with THR4. The function of the protein encoded by CTR86 is not yet clear, but the fact that the upstream region contains a GCN4 responsive site that the gene product may also be involved in amino acid biosynthesis.

Additional Material: 4 Ill.