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  • Articles  (2)
  • Data
  • Fracture  (1)
  • HLA-haploidentical bone marrow transplantation  (1)
  • 1985-1989  (2)
  • 1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: Stable immunological reconstitution and reversal of skeletal abnormalities (1989)
    Springer
    European journal of pediatrics 149 (1989), S. 104-109 
    Details
    ISSN: 1432-1076
    Keywords: Adenosine deaminase deficiency ; HLA-haploidentical bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentical parents as donors. In the first patient, two initial transplants failed to engraft and no change of the immunodeficiency was observed. In order to overcome this graft resistance, cytoreductive conditioning was used prior to a third transplant. In the other two patients, similar conditioning was used prior to initial transplants. In all three patients, complete and permanent immunological reconstitution was observed and they survive from 3.5 to 5 years after transplantation. In biopsies obtained from iliac bones prior to BMT, osteochondral abnormalities characteristic of ADA-deficiency were noted in all three patients. After successful transplantation, these abnormalities had completely resolved. Our results demonstrate that cytoreductive conditioning prior to HLA-haploidentical BMT is useful in order to obtain stable engraftment and reversal of abnormalities associated with ADA deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Advances in noninvasive bone measurement (1989)
    Springer
    Annals of biomedical engineering 17 (1989), S. 177-181 
    Details
    ISSN: 1573-9686
    Keywords: Bone ; Densitometry ; Osteoporosis ; Fracture ; Skeleton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Several noninvasive measurement methods are used for evaluation of metabolic disease. Single-photon (125I) scans of the peripheral skeleton are useful in some diseases but are ineffective in osteoporosis (even on the distal radius or os calcis) because they cannot predict spinal or femoral density. Also, peripheral measurements show high percentages of false negatives, that is many patients with fractures have normal peripheral density. Dual-photon (153Gd) scans of the spine, femur, and total skeleton are precise and accurate (2% error) and provide direct measurements of bone strength at fracture sites. This gives the best discrimination of abnormality and the most sensitive monitoring. Quantitative computed computed tomography (QCT) allows measurement of the spine but not the critical proximal femur area. QCT has a large accuracy error because (a) the limited are measured (under 5 cm3) fails to represent the total vertebral body, (b) technical errors and (c) variable fat and osteoid influence the results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02368026
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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