Electronic Resource
Springer
Journal of molecular medicine
65 (1987), S. 155-160
ISSN:
1432-1440
Keywords:
Hypertension
;
Ca2+
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Several disturbances of cellular Ca2+ metabolism have been described in essential hypertension and in the spontaneously hypertensive rat. Possibly the elevation of intracellular free Ca2+ concentration in arterial smooth muscle cells is one important step in the pathogenesis of primary hypertension. In most studies a decreased energy-dependent Ca2+ transport has been proposed as a mechanism. However, disturbances in cellular Ca2+ metabolism, which can be exclusively ascribed to essential hypertension, have not yet been found. The cause of altered cellular Ca2+ transport in primary hypertension may either be a genetically determined defect of membrane transport or a still-unidentified humoral factor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01728224
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