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  • Chemistry  (3)
  • Essential hypertension  (2)
  • Cell & Developmental Biology  (1)
  • Essentielle Hypertonie
  • General Chemistry
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  • 1990-1994  (3)
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  • 1980-1984  (3)
  • 1993  (3)
  • 1984  (3)
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  • 1990-1994  (3)
  • 1985-1989
  • 1980-1984  (3)
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  • 1
    Digitale Medien
    Digitale Medien
    Long-term effect of captopril on kidney function in various forms of hypertension (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 731-737 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Captopril ; Kidney function ; Essential hypertension ; Renovascular hypertension ; Renal parenchymatous hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To study long-term effects of captopril on renal function in patients with various forms of severe hypertension, serum creatinine values were monitored in 76 patients under captopril therapy over a period of up to 3 years. Three different groups were formed: (1) patients with essential hypertension (n=37); (2) patients with renovascular hypertension (n=20); (3) patients with renal parenchymatous hypertension (n=19). In each of the three groups reduction in blood pressure was accompanied by increases in serum creatinine. However, both changes were more pronounced in patients with renovascular hypertension. In this group only the rise in creatinine was statistically significant and showed a slight progression with duration of captopril treatment. Group specific analysis revealed that the increase was smaller in patients with unilateral (n=16) renovascular disease than in those with bilateral (n=4) involvement, but in the former it was still significantly higher than in patients with essential or renal parenchymatous hypertension. Separation of patients according to the underlying disease of renovascular hypertension showed that renal function deteriorated less in patients with arteriosclerotic origin (n=10) than in those with fibromuscular dysplasia (n=8). Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml·3 h were compared separately. A significant correlation (r=0.73;P〈0.05) between blood pressure reduction and creatinine changes was obtained only for patients with renovascular hypertension. Finally, in all three groups of patients creatinine changes were statistically independent from daily dosages of captopril. From these data we conclude that sustained impairment of kidney function by captopril is mainly restricted to patients with renovascular hypertension and possibly results from the combined effects of low renal perfusion pressure and interference with intrarenal regulation of glomerular filtration rate by a postulated angiotensin-II-mediated mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01725707
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  • 2
    Digitale Medien
    Digitale Medien
    Transdermal clonidine application: Long-term results in essential hypertension (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 925-930 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Transdermal therapeutic systems (TTS) ; Clonidine ; Essential hypertension ; Skin allergy ; Clonidine allergy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Skin patches of a clonidine transdermal therapeutic system (clonidine-TTS) with a constant release rate of either 0.1 or 0.2 mg clonidine/24 h continuously over 7 days were used in 32 essential hypertensives. These self-adhesive drug delivery systems (3.5 cm2), which were affixed to the upper outer arm, were changed by the patients at weekly intervals. During a mean observation period of 7 months (range 1–19 months) transdermal clonidine reduced the blood pressure from 162±15/107±5 mmHg to normal values (diastolic ≦95 mmHg) in 63% of our patients. However, chronic use of clonidine-TTS was accompanied by a high frequency of contact dermatitis (type IV allergy) in nearly half of our patients (n=15, 47%). In 11 of these 15 patients transdermal clonidine administration had to be stopped because of intolerable local skin reactions (pruritus, erythema, vesiculation, and/or infiltration). Subsequent patch testing with all components of clonidine-TTS was performed in eight cases. Whereas in seven cases an allergic contact dermatitis to clonidine was found, only one patient showed an allergy to another component of clonidine-TTS (polyisobutylene). We conclude that this strikingly high incidence of local allergic skin reactions limits the use of clonidine-TTS in essential hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01727445
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    64. Meßgenauigkeit und Störungen von Coriolis-Durchflußmessern bei pulsierender Fluidströmung (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 1088-1090 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330650966
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Druckschwingungen durch oszillierende Verdrängerpumpen in RohrleitungssystemenVortrag von G. Vetter auf dem Jahrestreffen der Verfahrens-Ingenieure, 30. Sept. bis 2. Okt. 1992 in Wien. (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 677-692 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Pressure Pulsations Caused by Reciprocating Pumps in Piping Systems. The safe design of piping installations for reciprocating pumps requires proper knowledge about the pump/installation interaction. In many cases critical resonance effects can be avoided by proper piping geometry or improved pump performance with respect to the volumetric efficiency (primary measures). Normally it is necessary to use various secondary dampening methods which can influence the acoustics of the piping system. Several examples of experimental computer simulations of damper action - upstream and downstream - are presented for fluidand gas-filled damper versions. The influence of entry geometry of the dampers is explained, hints on the proper geometry of the entries are given and the effects of various dampers and their influence on the total acoustics are discussed. Special reference is made to the effect of orifices as dissipative and acoustic elements in piping systems. The investigation shows the importance of analyzing of the total system of pump, piping installation and vessels or reactors and the application of computer simulation for piping design.
    Zusätzliches Material: 28 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330650603
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Metering Pumps. Selection and Application. Von P. Poynton. Marcel Dekker, Inc., New York - Basel 1983. 1. Aufl., XV, 216 S., zahlr. Abb. u. Tab., geb., SFr. 88,-. (1984)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 56 (1984), S. 62-62 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330560121
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  • 6
    Digitale Medien
    Digitale Medien
    In vitro expression of osteoblastic markers in cells isolated from normal fetal and postnatal human bone and from bone of patients with osteogenesis imperfecta (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 157 (1993), S. 439-444 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: We studied the expression of osteoblastic markers in cultured cells isolated from the bone of 15 patients with different clinical forms of osteogenesis imperfecta (OI) and of seven fetal and postnatal controls. Cultured bone cells of ten OI patients produced abnormal collagen type I. Similar to controls, OI bone cells produced predominantly collagen type I with traces of collagen types III and V. The 1,25(OH)2 vitamin D3-stimulated synthesis of osteocalcin, a specific osteoblastic marker protein, was similar in OI bone cells and age-matched controls. Bone cells from fetal controls and from patients with the perinatal lethal OI type II produced less osteocalcin than bone cells from postnatal controls and surviving OI patients. OI bone cells responded to parath.yroid hormone (PTH) by increased production of cAMP similar to controls. Bone cells from fetal controls and from OI type II donors showed a decreased response to PTH. Activity of the bone-liver-kidney isoenzyme alkaline phosphatase (AP) was detected in all control and OI bone cells. The expression of all osteoblastic markers was similar in bone cells producing abnormal collagen type I. These observations show that OI bone cells in vitro express a pattern of osteoblastic markers similar to age-matched control bone cells indicating that osteoblastic differentiation is not altered by the underlying defects of collagen type I metabolism in OI bone cells. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1041570302
    Standort Signatur Einschränkungen Verfügbarkeit
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