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  • 1
    Online Resource
    Online Resource
    Entwicklung neuartiger ökologischer Druckfarben unter Nutzung von Naturfarbstoffen aus Färberpflanzen und Untersuchung der technologischen Anforderungen zur Substitution umweltkritischer synthetischer Farbpigmente, Teilvorhaben 2: Bereitstellung von Naturfarbstoffen aus Färberpflanzen : Abschlussbericht ; Langtitel: Bereitstellung von Naturstoffen aus Färberpflanzen ; Kurztitel: Ökologische Druckfarben ; Projekt: Öl-, Energie- und Industriepföanzen ; Laufzeit: 11/2000 bis 6/2004 (2004)
    Jena
    Details Availability
    Keywords: Forschungsbericht ; Druckfarbe ; Färberpflanzen
    Type of Medium: Online Resource
    Pages: Online-Ressource (PDF-Datei: 39 S., 695 KB) , Ill., graph. Darst.
    Edition: [Online-Ausg.]
    URL: https://edocs.tib.eu/files/e01fb06/510712916.pdf
    URL: http://nbn-resolving.de/urn:nbn:de:gbv:27-20140714-112101-3
    URL: http://www.db-thueringen.de/servlets/DocumentServlet?id=24394
    URL: https://doi.org/10.2314/GBV:510712916
    URL: https://edocs.tib.eu/files/e01fb06/510712916l.pdf
    URN: urn:nbn:de:gbv:27-20140714-112101-3
    DOI: 10.2314/GBV:510712916
    Language: German
    Note: Förderkennzeichen BMVEL 00NR185/22018500. - Verbund-Nr. 01021534 , Unterschiede zwischen dem gedruckten Dokument und der elektronische Ressource können nicht ausgeschlossen werden , Auch als gedr. Ausg. erschienen , Systemvoraussetzungen: Acrobat reader.
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  • 2
    Electronic Resource
    Electronic Resource
    Long-Term Effectiveness of Operative Procedures for Stanford Type A Aortic Dissections (2004)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: The object was to evaluate the long-term effectiveness of strategies for managing the aortic root and distal aorta in type A dissections. Methods: From 1990 to 1999, 50 patients (32 men (64.07%); 18 women, (36.0%); mean age 57.4 ± 11.1 years) underwent operation for ascending aortic dissection. Surgical strategies included aortic root replacement with a composite graft (21/50; 42.0%), valve replacement with supracoronary ascending aortic graft (3/50, 6%), and valve preservation or repair (26/50; 52.0%). Results: Overall hospital mortality rate was 18.0%. Follow-up was completed for 47 patients (94.0%) and ranged from 1 month to 10.5 years (mean 28.8 months). Actuarial survival for patients discharged from the hospital was 84% at 1 year, 75% at 5 years, and 66% at 10 years. There was no significant difference between the various procedures regarding mortality, neurological complications, long-term survival, and proximal reoperations. The ascending aorta alone was replaced in 8 of 50 patients (16%), ascending and hemiarch in 30 of 50 patients (60%), and arch and proximal descending aorta in 12 of 50 patients (24%). Hospital mortality (11.5%, 20.0%, and 16.7%, respectively; p 〉 0.05) and 5- and 10-year survival (p 〉 0.05) were not statistically dependent on the extension of the resection distally. Residual distal dissection was not associated with a decrease in late survival. With regard to emergency surgery (36/50) there was no significant difference in hospital mortality (p 〉 0.05) and 5-year survival (p 〉 0.05) between those who had undergone coronary angiography (19/36; 52.8%) on the day of surgery with those who had not (17/36; 47.2%). Conclusions: Preservation or repair of the aortic valve can be recommended in the majority of patients with type A dissection. Distal extension of the resection does not increase surgical risk. Residual distal dissection does not decrease late survival. Preoperative coronary angiography may not affect survival in patients undergoing emergency surgery. (J Card Surg 2004;19:240-245)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04062.x
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  • 3
    Electronic Resource
    Electronic Resource
    The Edwards MIRA™ Heart Valve Prosthesis: (2004)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: The Edwards MIRA™ mechanical heart valve is designed to optimize hemodynamics, reduce thrombogenicity, and avoid mechanical failure with a special hinge mechanism. The purpose of the study was to investigate the clinical performance and postoperative hemodynamic results of the first European patients receiving Edwards MIRA™ mechanical heart valves. Methods: From March 1998 to March 1999 a total of 54 Edwards MIRA™ valves model numbers 3600 (aortic, n = 44) and 9600 (mitral, n = 10) were implanted in 52 (36 male, 16 female; mean age 61 ± 10.1 years) consecutive patients undergoing mechanical valve replacement in a prospective study. Follow-up of the patients including physical examination, ECG, blood tests, and Doppler were performed prior to discharge, at 6 months, at 1 year, and at least 2 years postoperatively. Results: Through October 2001 a total of 172 follow-up examinations were completed (51 patients at discharge, 46 patients at 6 months, 43 patients at 12 months, 32 patients at 2 years or beyond). All patients were in NYHA class I and II at the 6-month and 2+-year follow-up. All the patients stated an improved quality of life. Hospital mortality was 1.9%. There were no complications related to anticoagulation. Mean international normalized ratio at 6 months was 3.2 (range 1.9 to 4.3); lactate dehydrogenase was slightly increased with 264 ± 103 U/L on average (normal value 80 to 240 U/L). No signs of valvular dysfunction or paravalvular leakage were observed. Mean pressure gradients were related to valve diameter: after mitral valve replacement (size 27, 29, 31 mm: 4.8, 3.2, 2.1 mmHg); after aortic valve replacement (size 19, 21, 23, 25 mm: 12.1, 13.1, 9.3, 8.2 mmHg). Conclusions: These preliminary data suggest good hemodynamic function and a low rate of valve-related complications of the Edwards-MIRA™ mechanical prosthesis. (J Card Surg 2004;19:226-231)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04060.x
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  • 4
    Electronic Resource
    Electronic Resource
    The GTPase-activating protein Rap1GAP uses a catalytic asparagine (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 429 (2004), S. 197-201 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02505
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  • 5
    Electronic Resource
    Electronic Resource
    The maternal distribution and placental transfer of cadmium in zinc deficient rats (1978)
    Springer
    Bulletin of environmental contamination and toxicology 19 (1978), S. 556-563 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Although a transitory maternal zinc deficiency has been shown to result in an increased cadmium-induced fetotoxicity, the results of the present investigation indicated that a maternal zinc deficiency apparently did not affect the placental transfer of cadmium. However, a zinc deficiency did alter the maternal distribution of cadmium. The increased cadmium fetotoxicity associated with a maternal zinc deficiency may be caused by a maternal alteration rather than a direct effect on the fetus. Further study is necessary prior to any definitive statement concerning the effects of a maternal zinc deficiency on cadmium. fetotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01685841
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  • 6
    Electronic Resource
    Electronic Resource
    Fetal effects of cadmium in pregnant rats on normal and zinc deficient diets (1978)
    Springer
    Bulletin of environmental contamination and toxicology 19 (1978), S. 206-214 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary This investigation has shown that not only the extent of fetal resorption and malformation but also the types of malformation seen in rats depend upon the strain used and day of gestation. Furthermore, the effects of zinc deficiency and cadmium administration on the fetus can be at least additive, as was seen for malformations. For fetal resorption, zinc deficiency potentiated the action of cadmium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01685788
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  • 7
    Electronic Resource
    Electronic Resource
    Percutaneous transluminal dilatation: A new treatment of renovascular hypertension? (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 703-707 
    Details
    ISSN: 1432-1440
    Keywords: Renovaskuläre Hypertonie ; Renin ; Perkutane transluminale Dilatation ; Isotopennephrogramm ; Renovascular hypertension ; Renin ; Percutaneous transluminal dilatation ; Radionephrogram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Percutaneous transluminal dilatation of a left sided renal artery stenosis was performed in a 61 year old patient with hypertension. Biochemical and hemodynamic activity of the renal artery stenosis was demonstrated by measurement of renal venous renin-activity and determination of renal plasma flow and of pre- and poststenotic blood pressure values. Shortly after the dilatation procedure hypertension disappeared and renal plasma flow increased. The described procedure might be an alternative method to renal vascular surgery.
    Notes: Zusammenfassung Bei einem 61jährigen Patienten mit renovasculärer Hypertonie bei linksseitiger arteriosklerotischer Nierenarterienstenose wurde eine perkutane transluminale Dilatation der Stenose vorgenommen. Die biochemische und hämodynamische Aktivität der Nierenarterienstenose wurde durch Messung der Plasmareninaktivität im Nierenvenenblut, Bestimmung des renalen Plasmaflusses und der prä- und poststenotischen Blutdruckwerte in der Nierenarterie belegt. Kurz nach der Dilatation der Stenose normalisierte sich der Blutdruck, und es kam zu einem Anstieg des renalen Plasmaflusses. Weitere Untersuchungen werden zeigen, ob die beschriebene Methode eine Alternative zur operativen Korrektur der Nierenarterienstenose bietet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429105
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  • 8
    Electronic Resource
    Electronic Resource
    Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 229-234 
    Details
    ISSN: 1432-1440
    Keywords: Aldosteron ; Renin ; Cortisol ; Diabetes mellitus ; Hypoaldosteronismus ; Hyperkaliämie ; Aldosterone ; Renin ; Cortisol ; Diabetes ; Hypoaldosteronism ; Hyperkalemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In three patients with diabetes and hyporeninemic hypoaldosteronism changes in renin activity, plasma aldosterone and cortisol were examined under various conditions: orthostasis and intravenous furosemide, infusion of synthetic β1–24 ACTH on two consecutive days and diurnal variations in basal hormone fluctuations. Each patient showed unmeasurably low renin activity unresponsive to orthostasis and intravenous furosemide while plasma aldosterone was below normal range. Under ACTH-infusion only marked increases in aldosterone were observed in one patient whereas cortisol responded normally in all diabetics tested. Analysis of diurnal night day fluctuations (20.00–8.00) in plasma aldosterone and cortisol revealed a close and statistically significant relationship between both hormones in each of the three patients (p〈0.05–〈0.001). Variations in plasma aldosterone thus were mediated through changes in endogenous pituitary ACTH. Compared with normal controls however, diurnal aldosterone curves were set at a lower level. Our results demonstrate that a reduced sensitivity of the adrenal gland to ACTH is not responsible for the observed subnormal plasma aldosterone levels in these patients. Therefore, the lack of circulating angiotensin II seems to be the causative reason of hypoaldosteronism. The exact mechanism of undetectable renin activity in these patients remains unknown.
    Notes: Zusammenfassung Bei drei Patienten mit Diabetes mellitus und hyporeninämischem Hypoaldosteronismus wurden Veränderungen der Plasmareninaktivität, des Plasmaaldosteron- und Plasmacortisolspiegels unter folgenden Bedingungen geprüft: Orthostase und intravenöse Furosemidapplikation, Infusion von synthetischem β1–24 ACTH an zwei aufeinanderfolgenden Tagen, Tag-Nacht-Rhythmus der basalen Hormonplasmaspiegel. Alle Patienten zeigten eine nicht meßbare und durch Orthostase und Furosemid nicht stimulierbare Reninaktivität. Gleichzeitig wurden subnormale Aldosteronplasmakonzentrationen gemessen. Unter ACTH-Infusion zeigte nur ein Patient einen deutlichen Anstieg des Plasmaaldosterons, während das Plasmacortisol in allen drei Fällen normal stimulierbar war. Die statistische Analyse der Tag-Nacht-Schwankungen von Plasmaaldosteron und Plasmacortisol zeigte in jedem der Fälle eine enge und statistisch signifikante Beziehung zwischen beiden Hormonen (p〈0,05–〈0,001). Es ist somit anzunehmen, daß Schwankungen des Plasmaaldosterons durch Veränderungen der hypophysären ACTH-Ausschüttung verursacht wurden. Jedoch war im Vergleich zu Normalpersonen die Rhythmik des basalen Plasmaaldosterons auf einem tieferen Niveau eingestellt. Unsere Ergebnisse lassen den Schluß zu, daß bei diesen Patienten nicht eine verminderte Sensitivität der Nebennierenrinde auf ACTH für die beobachteten subnormalen Aldosteronspiegel verantwortlich ist. Ursache für den Hypoaldosteronismus scheint somit der Mangel an zirkulierendem Angiotensin II zu sein. Der genaue Mechanismus der nicht meßbaren Reninaktivität bei diesem Patienten bleibt unbekannt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477829
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  • 9
    Electronic Resource
    Electronic Resource
    The uptake of Manganese-54 by green algae (Protococcoidal chlorella), Daphnia magna, and fathead minnows (Pimephales promelas) (1978)
    Springer
    Hydrobiologia 59 (1978), S. 181-185 
    Details
    ISSN: 1573-5117
    Keywords: Manganese-54 ; concentration factor ; algae ; Daphnia ; minnows
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Concentration factors (CF) of 54Mn for three aquatic species: green algae (Protococcoidal chlorella), Daphnia magna, and fathead minnows (Pimephales promelas) were determined following direct exposure to the isotope in solution. The maximum accumulation (CF = 911) in P. chlorella was reached at 48 hours of exposure; the maximum uptake (CF = 65) in Daphnia was reached at 8 hours of exposure; and the maximum accumulation (CF = 22.6) in fathead minnows was at 128 hours of exposure. The data indicate that 54Mn accumulation decreases with ascent up a theoretical aquatic food chain when water is the only source of contamination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00036496
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  • 10
    Electronic Resource
    Electronic Resource
    Alkylaminopyridines and some Analogues as Derivatives for the structure elucidation of long aliphatic chains by mass spectrometryDedicated to Professor Edgar Lederer, Gif-sur-Yvette, on the occasion of his 70th birthday (1978)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 61 (1978), S. 1287-1295 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several long chain primary alcohols (saturated, monoolefinic and methyl branched) have been converted via their mesylates into various long chain alkylated aromatic compounds with basic character, and their mass spectra compared. The spectra of 2-alkylaminopyridines and to some extent those of 3-alkylaminopyridines exhibit most clearly the structure of the aliphatic chain, allowing the localization of branchings and double bonds.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19780610411
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