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  • PANGAEA  (24)
  • Nature Publishing Group (NPG)  (3)
  • Oxford University Press  (3)
  • Springer  (3)
  • American Physical Society (APS)  (1)
  • American Chemical Society
  • American Heart Association (AHA)
  • 2010-2014  (31)
  • 1995-1999
  • 1975-1979  (3)
  • 1970-1974
  • 1915-1919
  • 2012  (31)
  • 1976  (3)
Publikationsart
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  • 2010-2014  (31)
  • 1995-1999
  • 1975-1979  (3)
  • 1970-1974
  • 1915-1919
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    The effect of saralasin (1-Sar-8-Ala-Angiotensin II) on blood pressure in patients with cushing's syndrome (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 661-663 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Cushing-Syndrom ; Hypertonie ; Renin-Aktivität ; Aldosteronismus ; Cushing's syndrome ; Hypertension ; Renin activity ; Aldosteronism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary To investigate the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome two patients with hypercorticism were infused with 20 mg saralasin (1-sar-8-alaangiotensin II) over a period of 30 minutes under constant blood pressure control. In addition, one patient with primary aldosteronism, an established form of mineralocorticoid hypertension, served as control. Neither in the two patients with Cushing's syndrome nor in the patient with primary aldosteronism could a blood pressure lowering effect of saralasin be observed. In the two patients with hypercorticism both renin activity and plasma aldosterone increased during saralasin infusion. The patient with primary aldosteronism only showed a weak increase in plasma aldosterone concentration. These results seem to exclude an important role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome. The unresponsiveness of elevated blood pressure to saralasin in the two patients with hypercorticism and in the patient with primary aldosteronism indirectly supports the assumption that in patients with Cushing's syndrome increased mineralocorticoid activity may be the main factor in the pathogenesis of hypertension.
    Notizen: Zusammenfassung Um die Bedeutung des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom zu untersuchen, wurden bei 2 Patienten mit Hyperkortizismus 20 mg Saralasin (1-Sar-8-Ala-Angiotensin II) über einen Zeitraum von 30 min unter ständiger Blutdruckkontrolle infundiert. Zusätzlich diente ein Patient mit primärem Aldosteronismus, einer etablierten Form von Mineralokortikoidhochdruck, als Kontrolle. Weder bei den 2 Patienten mit Cushing-Syndrom noch bei dem Patienten mit primärem Aldosteronismus ließ sich ein blutdrucksenkender Effekt des Saralasins nachweisen. Die beiden Patienten mit Hyperkortizismus zeigten unter Saralasin sowohl einen Anstieg der Renin-Aktivität als auch des Plasmaaldosterons. Bei dem Patienten mit primärem Aldosteronismus ließ sich nur ein geringgradiger Anstieg der Plasmaaldosteronkonzentration nachweisen. Diese Ergebnisse sprechen gegen eine wichtige Rolle des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom. Die Unbeeinflußbarkeit des Hochdrucks durch Saralasin bei den beiden Patienten mit Hyperkortizismus und dem Patienten mit primärem Aldosteronismus stützen indirekt die Annahme, daß bei Patienten mit Cushing-Syndrom eine erhöhte Mineralokortikoidaktivität der Hauptfaktor in der Pathogenese der Hypertonie ist.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01469145
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Hyperfine structure measurement of the9Be+ 22 s 1/2 ground state by optical pumping (1976)
    Springer
    The European physical journal 276 (1976), S. 161-165 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Thermal9Be+ (I=3/2) ions are polarized by direct optical pumping in He buffer gas. Observation of⩼gDF=± 1 transitions yields for the hyperfine splitting frequencyv hfs(9Be+, 1s 2 2s 2 S 1/2)=1250018(5) kHz. The result is discussed with regard to predictions of recent theoretical calculations and of the Fermi-Segré formula for the ground state hfs of the Li isoelectronic sequence.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01412094
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Renin, aldosterone and arterial pressure responses to acute β-adrenergic receptor blockade in hypertensive patients (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 775-782 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Akute β-Rezeptorenblockade ; Hypertension ; Renin ; Aldosteron ; Tag-Nacht-Rhythmus ; Acute β-receptor blockade ; Hypertension ; Renin ; Aldosterone ; Day-night rhythm
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The effect of acute (intravenous) β-adrenergic blockade with propranolol or pindolol on arterial pressure (BP), plasma renin activity (PRA), and plasma concentration of aldosterone (PA) was evaluated in 20 essential hypertensive men. BP, PRA and PA were determined during continuous recumbency overnight (8 p.m. to 6 a.m.) every 30 min. Two groups of patients were observed. Patients of group I exhibited a characteristic day-night rhythm of PRA with low values before midnight and large increases early in the morning. Conversely, no rhythm and very low PRA values were observed in patients of group II. BP was higher in group II than in group I. In group I following intravenous propranolol or pindolol, BP fell within minutes and levels as well as rhythms of PRA were converted to those of group II without treatment. In group II day-night profiles of PRA and BP remained unchanged. Rhythm and concentration of PA in the two groups were not influenced by either drug. In 4 patients of group I infusion of angiotensin II inhibitor did not lower BP. The observations suggest that in the two groups dissimilarities in rhythms of PRA as well as in BP responses to β-blockade may reflect differences in neuro-adrenergic tone.
    Notizen: Zusammenfassung Der Einfluß einer akuten (intravenösen) β-Rezeptorenblockade mit Propranolol oder Pindololauf den Blutdruck (RR), die Plasma-Reninaktivität (PRA) und die Plasma-Aldosteronkonzentration (PA) wurde bei 20 Männern mit essentieller Hypertension untersucht. RR, PRA und PA wurden am liegenden Patienten nachts (20.00–6.00 Uhr) alle 30 min bestimmt. Zwei Gruppen von Patienten konnten unterschieden werden: Patienten der Gruppe I wiesen einen charakteristischen Tag-Nacht-Rhythmus in der Plasma-Reninaktivität auf, mit niedrigen Werten vor Mitternacht und hohen Werten am frühen Morgen. Im Gegensatz hierzu hatten die Patienten der Gruppe II sehr niedrige PRA-Werte; ein Rhythmus für PRA ließ sich nicht nachweisen. RR war höher in der Gruppe II als in Gruppe I. Nach Infusion von Propranolol oder Pindolol kam es in der Gruppe I zu einem schnellen RR-Abfall. Das Verhalten des Tag-Nacht-Profils für PRA war nach der β-Blockade vergleichbar mit demjenigen der Gruppe II vor der β-Blockade. In der Gruppe II blieben RR und Tag-Nacht-Profil von PRA unter β-Blockade unverändert. Rhythmus und Konzentration von PA wurden in beiden Gruppen nicht beeinflußt. Bei 4 Patienten der Gruppe I führte Angiotensin II-Blockade zu keiner RR-Senkung. Die Ergebnisse sind mit der Annahme vereinbar, daß die Unterschiede im Renin-Rhythmus und im Blutdruckverhalten nach akuter β-Rezeptorenblockade durch eine unterschiedliche neuroadrenerge Aktivität der beiden Gruppen bedingt sind.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01614294
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Unbekannt
    Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-10-04
    Beschreibung: Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling The EMBO Journal 31, 3795 (2012). doi:10.1038/emboj.2012.207 Authors: Irina Vetter, Filip Touska, Andreas Hess, Rachel Hinsbey, Simon Sattler, Angelika Lampert, Marina Sergejeva, Anastasia Sharov, Lindon S Collins, Mirjam Eberhardt, Matthias Engel, Peter J Cabot, John N Wood, Viktorie Vlachová, Peter W Reeh, Richard J Lewis & Katharina Zimmermann Ciguatoxins are sodium channel activator toxins that cause ciguatera, the most common form of ichthyosarcotoxism, which presents with peripheral sensory disturbances, including the pathognomonic symptom of cold allodynia which is characterized by intense stabbing and burning pain in response to mild cooling. We show that
    Schlagwort(e): ciguatoxincold allodyniaNavnociceptorTRPA1
    Print ISSN: 0261-4189
    Digitale ISSN: 1460-2075
    Thema: Biologie , Medizin
    Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).
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  • 5
    facet.materialart.
    Unbekannt
    Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-10-18
    Beschreibung: The EMBO Journal 31, 4085 (2012). doi:10.1038/emboj.2012.257 Authors: Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, Ingrid R Vetter, Carolin Koerner & Alfred Wittinghofer Access to the ciliary membrane for trans-membrane or membrane-associated proteins is a regulated process. Previously, we have shown that the closely homologous small G proteins Arl2 and Arl3 allosterically regulate prenylated cargo release from PDEδ. UNC119/HRG4 is responsible for ciliary delivery of myristoylated cargo. Here,
    Schlagwort(e): Arfsciliaprotein traffickingreleasing factorssmall G proteins
    Print ISSN: 0261-4189
    Digitale ISSN: 1460-2075
    Thema: Biologie , Medizin
    Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).
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  • 6
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    Unbekannt
    Flagellin Perception Varies Quantitatively in Arabidopsis thaliana and Its Relatives (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-05-16
    Beschreibung: Much is known about the evolution of plant immunity components directed against specific pathogen strains: They show pervasive functional variation and have the potential to coevolve with pathogen populations. However, plants are effectively protected against most microbes by generalist immunity components that detect conserved pathogen-associated molecular patterns (PAMPs) and control the onset of PAMP-triggered immunity. In Arabidopsis thaliana , the receptor kinase flagellin sensing 2 (FLS2) confers recognition of bacterial flagellin (flg22) and activates a manifold defense response. To decipher the evolution of this system, we performed functional assays across a large set of A. thaliana genotypes and Brassicaceae relatives. We reveal extensive variation in flg22 perception, most of which results from changes in protein abundance. The observed variation correlates with both the severity of elicited defense responses and bacterial proliferation. We analyzed nucleotide variation segregating at FLS2 in A. thaliana and detected a pattern of variation suggestive of the rapid fixation of a novel adaptive allele. However, our study also shows that evolution at the receptor locus alone does not explain the evolution of flagellin perception; instead, components common to pathways downstream of PAMP perception likely contribute to the observed quantitative variation. Within and among close relatives, PAMP perception evolves quantitatively, which contrasts with the changes in recognition typically associated with the evolution of R genes.
    Print ISSN: 0737-4038
    Digitale ISSN: 1537-1719
    Thema: Biologie
    Publiziert von Oxford University Press
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  • 7
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    Unbekannt
    GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-06-12
    Beschreibung: In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and is not merely a marker of gonadal-like differentiation in the neoplasms, we studied mice with germline or conditional loss-of-function mutations in the Gata4 gene. Germline Gata4 haploinsufficiency was associated with attenuated tumor growth and reduced expression of sex steroidogenic genes in the adrenal glands of ovariectomized B6D2F1 and B6AF1 mice. At 12 months after ovariectomy, wild-type B6D2F1 mice had biochemical and histological evidence of adrenocortical estrogen production, whereas Gata4 +/– B6D2F1 mice did not. Germline Gata4 haploinsufficiency exacerbated the secondary phenotype of postovariectomy obesity in B6D2F1 mice, presumably by limiting ectopic estrogen production in the adrenal glands. Amhr2 -cre-mediated deletion of floxed Gata4 ( Gata4 F ) in nascent adrenocortical neoplasms of ovariectomized B6.129 mice reduced tumor growth and the expression of gonadal-like markers in a Gata4 F dose-dependent manner. We conclude that GATA4 is a key modifier of gonadectomy-induced adrenocortical neoplasia, postovariectomy obesity, and sex steroidogenic cell differentiation.
    Print ISSN: 0013-7227
    Thema: Medizin
    Publiziert von Oxford University Press im Namen von The Endocrine Society.
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  • 8
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    Unbekannt
    Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-02-28
    Beschreibung: Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo . Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments performed in cultured cells revealed higher levels of H2B methylation when cells are dense, regardless of their cell cycle distribution. We identified dNTMT (CG1675) as the enzyme responsible for H2B methylation. We also found that the level of N-terminal methylation is regulated by dART8, an arginine methyltransferase that physically interacts with dNTMT and asymmetrically methylates H3R2. Our results demonstrate the existence of a complex containing two methyltransferases enzymes, which negatively influence each other’s activity.
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    facet.materialart.
    Unbekannt
    Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-12-19
    Beschreibung: Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities The ISME Journal 7, 224 (January 2013). doi:10.1038/ismej.2012.95 Authors: Ryan T Jones, Sara M Vetter, John Montenieiri, Jennifer Holmes, Scott A Bernhardt & Kenneth L Gage
    Schlagwort(e): Bartonellaexperimental infectionplague
    Print ISSN: 1751-7362
    Digitale ISSN: 1751-7370
    Thema: Biologie
    Publiziert von Nature Publishing Group (NPG) im Namen von The International Society for Microbial Ecology (ISME).
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  • 10
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    Band structure of ^{235}U (2012)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2012-12-22
    Beschreibung: Author(s): D. Ward, A. O. Macchiavelli, R. M. Clark, D. Cline, M. Cromaz, M. A. Deleplanque, R. M. Diamond, P. Fallon, A. Görgen, A. B. Hayes, G. J. Lane, I.-Y. Lee, T. Nakatsukasa, G. Schmidt, F. S. Stephens, C. E. Svensson, R. Teng, K. Vetter, and C. Y. Wu Over a period of several years we have performed three separate experiments at Lawrence Berkeley National Laboratory's 88-Inch Cyclotron in which 235 U (thick target) was Coulomb-excited. The program involved stand-alone experiments with Gammmasphere and with the 8pi Spectrometer using 136 Xe beams at... [Phys. Rev. C 86, 064319] Published Fri Dec 21, 2012
    Schlagwort(e): Nuclear Structure
    Print ISSN: 0556-2813
    Digitale ISSN: 1089-490X
    Thema: Physik
    Publiziert von American Physical Society (APS)
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