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  • PANGAEA  (24)
  • Nature Publishing Group (NPG)  (3)
  • Oxford University Press  (3)
  • Springer  (3)
  • American Heart Association (AHA)
  • Institute of Physics Publishing (IOP)
  • 2010-2014  (30)
  • 1995-1999
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  • 1975-1979
  • 1970-1974  (3)
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  • 2012  (30)
  • 1973  (3)
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  • 2010-2014  (30)
  • 1995-1999
  • 1990-1994
  • 1975-1979
  • 1970-1974  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Galactorrhea (1973)
    Springer
    Archives of gynecology and obstetrics 216 (1973), S. 81-90 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of galactorrhea in an unselected group of 5597 outpatients of our gynaecological department was 0.89%. Only one patient had amenorrhea simultaneously (0.02%). There is no age dependency of galactorrhea during the period of sexual maturity (between the age of 20 and 50). A few cases can be observed in the postmenopause. The percentage of galactorrhea ocouring after a previous pregnancy is extremely small. Based upon the chemical analysis of secretions from galactorrhea and of normal human breast milk it is obvious that the two fluids are not identical. Irregularities of the menstrual cycles are present mainly in the form of monophasic cycles. There is a high incidence of pathological fasting plasma glucose concentrations (approx. 20%). An attempt is made to detect the different causes for galactorrhea. In more than 50% of the patients morphological alterations of the mammary tissue can be found. Six times there were intracanalicular papillomas. A procedure for the diagnosis of an uncomplicated galactorrhea is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00672677
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Zu einem Satz von G. Trautmann über den Rang gewisser kohärenter analytischer Moduln (1973)
    Springer
    Archiv der Mathematik 24 (1973), S. 158-161 
    Details
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01228192
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Episodische Cortisolsekretion bei Cusing-Syndrom (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1025-1026 
    Details
    ISSN: 1432-1440
    Keywords: Cushing's syndrome ; hydrocortison ; circadian rhythm ; Cushing-Syndrom ; Cortisol ; Tagesrhythmus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wiederholte ambulante Plasmacortisolbestimmungen bei einer Patientin mit deutlichen klinischen Zeichen des Hyperkortizismus ergaben mit 16–24 µg/100 ml normale Werte. Erst ein unter standardisierten Bedingungen erstelltes Plasmacortisol-Tagesprofil erbrachte den eindeutigen Nachweis der Hypercortisolämie. Im Vergleich zu gesunden Normalpersonen liegen die Plasmacortisolspiegel der Cushing-Patientin auf einer höheren Ebene. Die physiologischen Phasen ruhender Cortisolsekretion in den Abend- und Nachtstunden fehlen. Wie bei Gesunden können wir bei diesem Fall von Hypercortic ismus, beruhend auf bilateraler Nebennierenrinden-Hyperplasie, große Schwankungen des Plasmacortisolspiegels beobachten. Der Wert wiederholter Plasmacortisolbestimmungen in der Abklärung des Cushing-Syndroms wird diskutiert.
    Notes: Summary In a patient with typical features of Cushing's disease, repeated ambulant determinations of plasma cortisol showed normal values with 16 to 24 µg/100 ml. The entire analysis of the circadian variations of plasma cortisol under standardized conditions led to the diagnosis of hypercorticism. Compared with 2 healthy subjects the patient's curve is set at a higher level. Physiological, quiet periods of cortisol secretion in late day-time do not occur. In accord to the normal, we find great variations of plasma cortisol in this case of Cushing's syndrome due to bilateral adrenal hyperplasia. The diagnostic value of plasma cortisol determinations at short term intervals in differentiating the various forms of hypercorticism is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468296
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  • 4
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    Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-10-04
    Description: Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling The EMBO Journal 31, 3795 (2012). doi:10.1038/emboj.2012.207 Authors: Irina Vetter, Filip Touska, Andreas Hess, Rachel Hinsbey, Simon Sattler, Angelika Lampert, Marina Sergejeva, Anastasia Sharov, Lindon S Collins, Mirjam Eberhardt, Matthias Engel, Peter J Cabot, John N Wood, Viktorie Vlachová, Peter W Reeh, Richard J Lewis & Katharina Zimmermann Ciguatoxins are sodium channel activator toxins that cause ciguatera, the most common form of ichthyosarcotoxism, which presents with peripheral sensory disturbances, including the pathognomonic symptom of cold allodynia which is characterized by intense stabbing and burning pain in response to mild cooling. We show that
    Keywords: ciguatoxincold allodyniaNavnociceptorTRPA1
    Print ISSN: 0261-4189
    Electronic ISSN: 1460-2075
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG) on behalf of The European Molecular Biology Organization (EMBO).
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  • 5
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    Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-10-18
    Description: The EMBO Journal 31, 4085 (2012). doi:10.1038/emboj.2012.257 Authors: Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, Ingrid R Vetter, Carolin Koerner & Alfred Wittinghofer Access to the ciliary membrane for trans-membrane or membrane-associated proteins is a regulated process. Previously, we have shown that the closely homologous small G proteins Arl2 and Arl3 allosterically regulate prenylated cargo release from PDEδ. UNC119/HRG4 is responsible for ciliary delivery of myristoylated cargo. Here,
    Keywords: Arfsciliaprotein traffickingreleasing factorssmall G proteins
    Print ISSN: 0261-4189
    Electronic ISSN: 1460-2075
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG) on behalf of The European Molecular Biology Organization (EMBO).
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  • 6
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    Flagellin Perception Varies Quantitatively in Arabidopsis thaliana and Its Relatives (2012)
    Oxford University Press
    Details
    Publication Date: 2012-05-16
    Description: Much is known about the evolution of plant immunity components directed against specific pathogen strains: They show pervasive functional variation and have the potential to coevolve with pathogen populations. However, plants are effectively protected against most microbes by generalist immunity components that detect conserved pathogen-associated molecular patterns (PAMPs) and control the onset of PAMP-triggered immunity. In Arabidopsis thaliana , the receptor kinase flagellin sensing 2 (FLS2) confers recognition of bacterial flagellin (flg22) and activates a manifold defense response. To decipher the evolution of this system, we performed functional assays across a large set of A. thaliana genotypes and Brassicaceae relatives. We reveal extensive variation in flg22 perception, most of which results from changes in protein abundance. The observed variation correlates with both the severity of elicited defense responses and bacterial proliferation. We analyzed nucleotide variation segregating at FLS2 in A. thaliana and detected a pattern of variation suggestive of the rapid fixation of a novel adaptive allele. However, our study also shows that evolution at the receptor locus alone does not explain the evolution of flagellin perception; instead, components common to pathways downstream of PAMP perception likely contribute to the observed quantitative variation. Within and among close relatives, PAMP perception evolves quantitatively, which contrasts with the changes in recognition typically associated with the evolution of R genes.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice (2012)
    Oxford University Press
    Details
    Publication Date: 2012-06-12
    Description: In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and is not merely a marker of gonadal-like differentiation in the neoplasms, we studied mice with germline or conditional loss-of-function mutations in the Gata4 gene. Germline Gata4 haploinsufficiency was associated with attenuated tumor growth and reduced expression of sex steroidogenic genes in the adrenal glands of ovariectomized B6D2F1 and B6AF1 mice. At 12 months after ovariectomy, wild-type B6D2F1 mice had biochemical and histological evidence of adrenocortical estrogen production, whereas Gata4 +/– B6D2F1 mice did not. Germline Gata4 haploinsufficiency exacerbated the secondary phenotype of postovariectomy obesity in B6D2F1 mice, presumably by limiting ectopic estrogen production in the adrenal glands. Amhr2 -cre-mediated deletion of floxed Gata4 ( Gata4 F ) in nascent adrenocortical neoplasms of ovariectomized B6.129 mice reduced tumor growth and the expression of gonadal-like markers in a Gata4 F dose-dependent manner. We conclude that GATA4 is a key modifier of gonadectomy-induced adrenocortical neoplasia, postovariectomy obesity, and sex steroidogenic cell differentiation.
    Print ISSN: 0013-7227
    Topics: Medicine
    Published by Oxford University Press on behalf of The Endocrine Society.
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  • 8
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    Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster (2012)
    Oxford University Press
    Details
    Publication Date: 2012-02-28
    Description: Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo . Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments performed in cultured cells revealed higher levels of H2B methylation when cells are dense, regardless of their cell cycle distribution. We identified dNTMT (CG1675) as the enzyme responsible for H2B methylation. We also found that the level of N-terminal methylation is regulated by dART8, an arginine methyltransferase that physically interacts with dNTMT and asymmetrically methylates H3R2. Our results demonstrate the existence of a complex containing two methyltransferases enzymes, which negatively influence each other’s activity.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 9
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    Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-12-19
    Description: Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities The ISME Journal 7, 224 (January 2013). doi:10.1038/ismej.2012.95 Authors: Ryan T Jones, Sara M Vetter, John Montenieiri, Jennifer Holmes, Scott A Bernhardt & Kenneth L Gage
    Keywords: Bartonellaexperimental infectionplague
    Print ISSN: 1751-7362
    Electronic ISSN: 1751-7370
    Topics: Biology
    Published by Nature Publishing Group (NPG) on behalf of The International Society for Microbial Ecology (ISME).
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  • 10
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    Technical comments on the data records from the Vernagtbach station for the period 1970 to 2001 (2012)
    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
    Format: application/pdf
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