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  • Essential hypertension  (2)
  • Fisheries  (2)
  • 2020-2022  (2)
  • 2000-2004
  • 1980-1984  (2)
  • 1965-1969
  • 1955-1959
  • 2021  (2)
  • 2004
  • 1984  (2)
  • 1959
  • 1956
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  • 2020-2022  (2)
  • 2000-2004
  • 1980-1984  (2)
  • 1965-1969
  • 1955-1959
Jahr
  • 1
    ISSN: 1432-1440
    Schlagwort(e): Captopril ; Kidney function ; Essential hypertension ; Renovascular hypertension ; Renal parenchymatous hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To study long-term effects of captopril on renal function in patients with various forms of severe hypertension, serum creatinine values were monitored in 76 patients under captopril therapy over a period of up to 3 years. Three different groups were formed: (1) patients with essential hypertension (n=37); (2) patients with renovascular hypertension (n=20); (3) patients with renal parenchymatous hypertension (n=19). In each of the three groups reduction in blood pressure was accompanied by increases in serum creatinine. However, both changes were more pronounced in patients with renovascular hypertension. In this group only the rise in creatinine was statistically significant and showed a slight progression with duration of captopril treatment. Group specific analysis revealed that the increase was smaller in patients with unilateral (n=16) renovascular disease than in those with bilateral (n=4) involvement, but in the former it was still significantly higher than in patients with essential or renal parenchymatous hypertension. Separation of patients according to the underlying disease of renovascular hypertension showed that renal function deteriorated less in patients with arteriosclerotic origin (n=10) than in those with fibromuscular dysplasia (n=8). Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml·3 h were compared separately. A significant correlation (r=0.73;P〈0.05) between blood pressure reduction and creatinine changes was obtained only for patients with renovascular hypertension. Finally, in all three groups of patients creatinine changes were statistically independent from daily dosages of captopril. From these data we conclude that sustained impairment of kidney function by captopril is mainly restricted to patients with renovascular hypertension and possibly results from the combined effects of low renal perfusion pressure and interference with intrarenal regulation of glomerular filtration rate by a postulated angiotensin-II-mediated mechanism.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 62 (1984), S. 925-930 
    ISSN: 1432-1440
    Schlagwort(e): Transdermal therapeutic systems (TTS) ; Clonidine ; Essential hypertension ; Skin allergy ; Clonidine allergy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Skin patches of a clonidine transdermal therapeutic system (clonidine-TTS) with a constant release rate of either 0.1 or 0.2 mg clonidine/24 h continuously over 7 days were used in 32 essential hypertensives. These self-adhesive drug delivery systems (3.5 cm2), which were affixed to the upper outer arm, were changed by the patients at weekly intervals. During a mean observation period of 7 months (range 1–19 months) transdermal clonidine reduced the blood pressure from 162±15/107±5 mmHg to normal values (diastolic ≦95 mmHg) in 63% of our patients. However, chronic use of clonidine-TTS was accompanied by a high frequency of contact dermatitis (type IV allergy) in nearly half of our patients (n=15, 47%). In 11 of these 15 patients transdermal clonidine administration had to be stopped because of intolerable local skin reactions (pruritus, erythema, vesiculation, and/or infiltration). Subsequent patch testing with all components of clonidine-TTS was performed in eight cases. Whereas in seven cases an allergic contact dermatitis to clonidine was found, only one patient showed an allergy to another component of clonidine-TTS (polyisobutylene). We conclude that this strikingly high incidence of local allergic skin reactions limits the use of clonidine-TTS in essential hypertension.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    facet.materialart.
    Unbekannt
    In:  http://aquaticcommons.org/id/eprint/8700 | 403 | 2012-06-07 14:51:15 | 8700 | United States National Marine Fisheries Service
    Publikationsdatum: 2021-06-25
    Beschreibung: The broad distribution of Pacific sardine (Sardinops sagax)along the Pacif ic coast of North America makes it difficult for fisheries managers to identify regionalstocks of this dominant small pelagic species. An investigation of morphometric characteristics of otoliths ofPacific sardine across most of their range revealed regional differences in populations. In a survey of over 2000 otoliths, all ages (with an emphasis on age-1 recruits) were compared. Principal components analysis, multivariate analysis of variance, and a novel method derived from regression and residuals calculations, termedperimeter-weight profiles (PWPs), revealed otolith similarities and differences. The results of the differentapproaches to statistical comparisons did not always agree. Sardine otoliths from Mexican waters were generallylighter and more lobate than those from U.S. and Canadian populations. Age-1 otoliths from northern California in 2006–07 tended to be heavier and smoother than those from other areas, including year-class cohorts from southern California. Comparisons of age-groups and year-classes of northern California otoliths with the use of the PWP models indicated signif icant trends in year-to-year patterns. In conjunction with other established indices of populationstructure, otolith PWPs are a useful tool for identifying local and regional stocks of Pacific sardine and may helpdistinguish populations of other fish species as well.
    Schlagwort(e): Biology ; Ecology ; Fisheries
    Repository-Name: AquaDocs
    Materialart: article , TRUE
    Format: application/pdf
    Format: application/pdf
    Format: 402-415
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    In:  http://aquaticcommons.org/id/eprint/12092 | 9601 | 2013-10-29 19:52:00 | 12092 | Gulf and Caribbean Fisheries Institute
    Publikationsdatum: 2021-07-01
    Schlagwort(e): Fisheries ; GCFI
    Repository-Name: AquaDocs
    Materialart: conference_item
    Format: application/pdf
    Format: application/pdf
    Format: 56-63
    Standort Signatur Einschränkungen Verfügbarkeit
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