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  • Springer  (52)
  • Nature Publishing Group (NPG)  (3)
  • Oxford University Press  (3)
  • Jena  (1)
  • American Heart Association (AHA)
  • Macmillan Magazines Ltd.
  • 2010-2014  (7)
  • 1995-1999  (45)
  • 1970-1974  (3)
  • 1955-1959  (5)
  • 1870-1879
  • 2012  (7)
  • 1998  (13)
  • 1996  (14)
  • 1995  (18)
  • 1972  (3)
  • 1958  (4)
  • 1956  (1)
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  • 2010-2014  (7)
  • 1995-1999  (45)
  • 1970-1974  (3)
  • 1955-1959  (5)
  • 1870-1879
Jahr
  • 21
    Digitale Medien
    Digitale Medien
    Transport of small organic cations in the rat liver The role of the organic cation transporter OCT1 (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 320-326 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Key words Rat liver ; Transport of organic cations ; OCT1 ; Type I hepatic transport of cationic drugs ; 1-Methyl-4-phenylpyridinium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The kidneys and the liver are the principal organs for the inactivation of circulating organic cations. Recently, an organic cation transporter (OCT1) has been cloned from rat kidney. In order to answer the question whether OCT1 is involved also in hepatic uptake of organic cations, the pharmacological characteristics of organic cation transport in hepatocytes were compared to the characteristics of transiently expressed OCT1. Primary cultures of rat hepatocytes avidly accumulated the small organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+). At equilibrium, the hepatocytes accumulated 3H-MPP+ 56-fold. Initial rates of specific 3H-MPP+ transport in hepatocytes were saturable. The half-saturating concentration was 13 μmol/l. 3H-MPP+ transport was sensitive to quinine (Ki = 0.79 μmol/l) and cyanine863 (Ki = 0.097 μmol/l). Quinine and cyanine863 are known inhibitors of type I hepatic transport of cationic drugs and of renal excretion of organic cations, respectively. To compare the functional characteristics of 3H-MPP+ transport in hepatocytes with those of OCT1, OCT1 has been heterologously expressed and characterized in a mammalian cell line (293 cells). Initial rates of 3H-MPP+ transport were saturable, the Km being 13 μmol/l. The rank order of inhibitory potencies of various inhibitors was almost identical in hepatocytes and 293 cells transiently transfected with OCT1. There was a positive correlation between the Ki’s for the inhibition of 3H-MPP+ transport in isolated hepatocytes and transfected 293 cells (r = 0.85; P〈0.01; n = 8). The results indicate that OCT1 is functionally expressed not only in the kidney but also in hepatocytes where it is responsible for the transport of small organic cations which, in the past, have been classified as type I substrates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00171063
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  • 22
    Digitale Medien
    Digitale Medien
    Experiments on the Richtmyer-Meshkov instability of an air/SF6 interface (1995)
    Springer
    Shock waves 4 (1995), S. 247-252 
    Details
    ISSN: 1432-2153
    Schlagwort(e): Richtmyer-Meshkov instability ; Flow visualization ; Experiment ; Shock tube ; Turbulent mixing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik , Technik allgemein
    Notizen: Abstract Results of flow visualization experiments of an impulsively accelerated plane interface between air and SF6 are reported. The shock tube used for the experiments has a larger test section than in previous experiments. The larger extent of uniform test flow relative to nonuniform boundary-layer flow permits unambiguous interpretation of flow-visualization photographs, and the influence of shock-wave/boundary-layer interactions is no longer dominant. The strong wall vortex observed in previous studies is not observed in these experiments. It is found that the thin membrane, which forms the initially plane interface, has a significant influence on the initial growth rate of the interface thickness. However, the measured growth rates after the first reflected shock are independent of membrane configuration and are in good agreement with analytical predictions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01416035
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  • 23
    Digitale Medien
    Digitale Medien
    Case of the month (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 935-936 
    Details
    ISSN: 1432-1076
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01957510
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  • 24
    Digitale Medien
    Digitale Medien
    Lens sorbitol dehydrogenase deficiency in a patient with congenital cataract (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 389-391 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Sorbitol dehydrogenase ; Lens ; Congenital cataract
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Lens sorbitol dehydrogenase activity was assayed in patients with congenital cataracts, senile cataracts, without cataracts and in one fetal lens. In patients with congenital cataracts we did not observe any abnormality of galactose and sorbitol metabolising enzymes in erythrocytes. In one of these patients with inexplicable congenital cataracts lens sorbitol dehydrogenase deficiency was found. Conclusion Determination of galactose metabolising enzymes, sorbitol dehydrogenase and polyols in lenses may help in understanding the mechanism of formation of inexplicable congenital cataracts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02072111
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  • 25
    Digitale Medien
    Digitale Medien
    Studies of multimodal evoked potentials in treated phenylketonuria: the pattern of vulnerability (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S64 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Hyperphenylaninaemia ; Phenylketonuria ; Evoked potentials ; Metabolic disorders ; Dopamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We performed studies of multimodal evoked potentials and peripheral sensory and motor nerve conductions in 33 early and 6 late treated patients with phenylketonuria. The studies revealed the following picture: 1. In 27% of early treated patients latencies of visual evoked potentials were increased. The cause for these changes is unknown. 2. Nerve conduction studies showed the presence of a minor sensory neuropathy which in rare cases may also affect peripheral motor nerves. This neuropathy did not have features of a central-peripheral distal axonopathy which argues against a toxic/nutritional causation. 3. Deficits in the central sensory, motor, and auditory pathways were present, but rare in early treated patients. If the results of electrophysiological studies reported by different groups are compared, the emerging picture is very similar and the majority of the – minor – differences is likely to be explained by technical aspects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00014254
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  • 26
    Digitale Medien
    Digitale Medien
    Nitinol Esophageal Stents: New Designs and Clinical Indications (1996)
    Springer
    CardioVascular & interventional radiology 19 (1996), S. 15-20 
    Details
    ISSN: 1432-086X
    Schlagwort(e): Key words: Esophagus〈+〉—〈+〉Stenosis or obstruction〈+〉—〈+〉Interventional procedure〈+〉—〈+〉Grafts and prostheses
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: To evaluate the clinical use of covered and noncovered, knitted nitinol stents in patients presenting new stent indications. Methods: Self-expandable, knitted nitinol stents were implanted in four patients for treatment of dysphagia. In two patients who had malignant strictures and had esophago-respiratory fistulae and in one patient with an esophagocutaneous fistula, polytetrafluoroethylene (PTFE)-covered stents were implanted. One patient received a noncovered stent, but a retrograde approach through a percutaneous endoscopic gastrostomy (PEG) fistula had to be chosen for recanalization of an esophageal occlusion. Two patients received stents for treatment of benign strictures. Results: Recanalization of the stricture and stent implantation were performed under fluoroscopic control without any procedure-related morbidity or mortality. Dysphagia improved in all patients and the esophageal fistulae could be sealed off by covered stents. During a maximum follow-up of 18 months, there was no stent migration or esophageal perforation. Complications observed were stent stenosis due to food impaction (1/4) and benign stent stenosis (2/2). Most complications could be treated by the interventional radiologist. Conclusion: Self-expandable, covered Nitinol stents provide an option for the treatment of dysphagia combined with esophageal fistulae. In combination with interventional radiology techniques, even complex strictures are accessible. For benign strictures, the value of stent treatment has not yet been proven.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002709900003
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  • 27
    Digitale Medien
    Digitale Medien
    Low-Molecular-Weight Heparin (Reviparin) Reduces the Incidence of Femoropopliteal In-Stent Stenosis: Preliminary Results of an Ongoing Study (1998)
    Springer
    CardioVascular & interventional radiology 21 (1998), S. 375-379 
    Details
    ISSN: 1432-086X
    Schlagwort(e): Key words: Arteries, extremities—Grafts and prostheses—Transluminal angioplasty—Stenosis or obstruction—Heparin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: To examine the efficacy of the low-molecular-weight heparin, reviparin, for prevention of femoropopliteal stent restenosis. Methods: Forty-two patients who had implantation of flexible tantalum stents for the treatment of stenosis (n= 24) or occlusion (n= 18) of the femoral (n= 27) or popliteal (n= 15) arteries were included in this study protocol. An intraarterial bolus of 5000 IU heparin was given before percutaneous transluminal angioplasty (PTA), and in the case of stent implantation due to unsuccessful PTA, an additional dose of reviparin (3500 anti-factor Xa IU) was given. Postprocedurally, 10,500 anti-factor Xa IU of reviparin were administered intravenously over 24 hr, followed by 3500 anti-factor Xa IU subcutaneously twice a day for 23 days. Oral aspirin (100 mg/day) was prescribed for the long term. Follow-up criteria (maximum follow-up 37 months) were clinical symptoms, Doppler ankle arm indices, color and duplex sonography, and angiography for suspicion of restenosis. Results: Early stent thromboses were not observed. Overall primary patency rate (PPR) was 88% ± 6.0% (1 year) and 74% ± 10.1% (2 years). Major hemorrhagic complications have not occurred. Conclusion: Reviparin administered in a high dose over a period of 24 days is a safe medication regimen and provides excellent patency rates after stent implantation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002709900283
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  • 28
    Digitale Medien
    Digitale Medien
    Lens sorbitol dehydrogenase deficiency in a patient with congenital cataract (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 389-391 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Sorbitol dehydrogenase ; Lens ; Congenital cataract
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Lens sorbitol dehydrogenase activity was assayed in patients with congenital cataracts, senile cataracts, without cataracts and in one fetal lens. In patients with congenital cataracts we did not observe any abnormality of galactose and sorbitol metabolising enzymes in erythrocytes. In one of these patients with inexplicable congenital cataracts lens sorbitol dehydrogenase deficiency was found. Conclusion Determination of galactose metabolising enzymes, sorbitol dehydrogenase and polyols in lenses may help in understanding the mechanism of formation of inexplicable congenital cataracts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004310050311
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  • 29
    Digitale Medien
    Digitale Medien
    Sulfur contents and sulfur-isotope compositions of thiotrophic symbioses in bivalve molluscs and vestimentiferan worms (1998)
    Springer
    Marine biology 132 (1998), S. 453-460 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Total sulfur (STOT), elemental sulfur (S°) and sulfur-isotope compositions (δ34S) of marine animals were analyzed to determine whether these chemical characteristics could help distinguish animals with a sulfur-based, thiotrophic nutrition from animals whose nutrition is based on methanotrophy or on more normal consumption of phytoplankton-derived organic matter. The presence of S° was almost entirely confined to the symbiont-containing tissues of thiotrophs, but was sometimes undetectable in thiotrophic species where sulfide availability was probably low. When S° contents were subtracted, the remaining tissue-sulfur concentrations were similar for all nutritional groups. δ34S values were typically lower for thiotrophs than for other groups, although there was overlap in methanotroph and thiotroph values at some sites. Field evidence supported the existence of small to moderate (1 to 10‰)34S fractionations in the uptake of sulfides and metabolism of thiosulfate. In general, a total sulfur content of 〉3% dry weight, the presence of elemental sulfur, and δ34S values less than +5‰ can be used to infer a thiotrophic mode of nutrition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002270050411
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  • 30
    Digitale Medien
    Digitale Medien
    Life-history patterns of two Southern CaliforniaNebalia species (Crustacea: Leptostraca): the failure of form to predict function (1996)
    Springer
    Marine biology 127 (1996), S. 131-141 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Laboratory and field studies onNebalia hessleri andN. daytoni off the toast of San Diego, Southern California, showed that although morphologically similar, the habitats, behavior, and natural history of these two species are surprisingly different. In laboratory experiments, Bach species avoided the other's habitat (sand and mats of macrophyte detritus), and in the field, transplanted individuals failed to survive in the other species' habitat.N. hessleri, which inhabits subtidal mats of macrophyte detritus, survived and reproduced well in the laboratory, was iteroparous, and a large percentage of adults were male. This species occurred at very high densities in the field, and ate essentially everything offered in the laboratory, with a diet in the field consisting largely of plant detritus and carrion. The other species,N. daytoni, differed in nearly every way, it inhabited organically impoverished sands, survived poorly in the laboratory, was apparently semelparous, and a small percentage of the adult population was male.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00993653
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