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Kohlenstoffbasierte Schichten (2002)

Vetter, Jörg

[Bergisch-Gladbach] : Sulzer Metaplas Ionon Oberflächenveredelungstechnik GmbH

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Beschreibung / Inhaltsverzeichnis: Vacuum arc evaporation, PVD, DLC, carbon coatings, dry operation, friction reduction, tool coating, hard coatings

Materialart: Online-Ressource

Seiten: Online-Ressource (96 p. = 12,1 MB) , ill., graphs

Ausgabe: [Elektronische Ressource]

Serie: BMBF-Projekt Trockenschmierstoffschichten für die Zerspanung und Umformung : Verbundvorhaben; Abschlußbericht Teilvorhaben [3], [Sulzer Metaplas Ionon Oberflächenveredelungstechnik GmbH]

URL: https://edocs.tib.eu/files/e01fb02/358041651.pdf

URL: https://edocs.tib.eu/files/e01fb02/358041651l.pdf

Sprache: Deutsch , Englisch

Anmerkung: Contract BMBF 03N5015C 0. - Differences between the printed and electronic version of the document are possible. - Engl. abstract under title: Carbon based coatings. - nIndex p. 94 - 96 , Also available as printed version , Systemvoraussetzungen: Acrobat Reader.

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Digitale Medien

Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein (2002)

Lötsch, Jörn ; Schmidt, Rodolfo ; Vetter, Gregor ; [weitere]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 83 (2002), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Morphine-6-glucuronide (M6G) is a substrate of P-glycoprotein (P-gp), which forms an outward transporter at the blood–brain barrier. Inhibition of P-gp may therefore be expected to cause increased CNS uptake of M6G. We directly assessed the spinal concentrations of M6G and its antinociceptive effects in rats following pharmacological inhibition of P-gp. Spinal cord tissue concentrations of M6G were assessed by microdialysis with probes transversally implanted through the dorsal horns of the spinal cord at level L4. Ten rats received M6G intravenously (0.018 mg/kg loading dose plus 0.00115 mg/kg/min for an 8-h infusion), five of them together with PSC833 to inhibit P-gp (32-h infusion, starting 24 h before the addition of M6G). Antinociceptive effects were explored by means of formalin tests. After having obtained evidence for enhanced CNS uptake and antinociception of M6G in the presence of PSC833, additional behavioural experiments were performed in another 32 rats to assess the dose dependency of the antinociceptive effects of M6G either with or without PSC833 in comparison with both PSC833 alone and placebo. Inhibition of P-gp increased the M6G concentrations in the spinal cord approximately three-fold whereas the plasma concentrations were increased only by a factor of 1.4, which resulted in a more than doubled spinal cord/plasma concentration ratio (from 0.08 ± 0.03 for M6G alone to 0.17 ± 0.08 for M6G plus PSC833). Antinociceptive effects of M6G were significantly enhanced by inhibition of P-gp. Inhibition of P-gp alters the transport of M6G across the blood–brain barrier, resulting in enhanced spinal cord uptake and enhanced antinociception.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.2002.01177.x

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Digitale Medien

Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E2 release in the spinal cord (2001)

Tegeder, Irmgard ; Niederberger, Ellen ; Vetter, Gregor ; [weitere]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 79 (2001), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Nociception evoked prostaglandin (PG) release in the spinal cord considerably contributes to the induction of hyperalgesia and allodynia. To evaluate the relative contribution of cyclooxygenase-1 (COX-1) and COX-2 in this process we assessed the effects of the selective COX-1 inhibitor SC560 and the selective COX-2 inhibitor celecoxib on formalin-evoked nociceptive behaviour and spinal PGE2 release. SC560 (10 and 20 mg/kg) significantly reduced the nociceptive response and completely abolished the formalin-evoked PGE2 raise. In contrast, celecoxib (10 and 20 mg/kg) was ineffective in both regards, i.e. the flinching behaviour was largely unaltered and the formalin-induced PGE2 raise as assessed using microdialysis was only slightly, not significantly reduced. This suggests that the formalin-evoked rapid PG release was primarily caused by COX-1 and was independent of COX-2. Mean free spinal cord concentrations of celecoxib during the formalin assay were 32.0 ± 4.5 nm, thus considerably higher than the reported IC50 for COX-2 (3–7 nm). Therefore, the lack of efficacy of celecoxib is most likely not to be a result of poor tissue distribution. COX-2 mRNA and protein expression in the spinal cord were not affected by microdialysis alone but the mRNA rapidly increased following formalin injection and reached a maximum at 2 h. COX-2 protein was unaltered up to 4 h after formalin injection. The time course of COX-2 up-regulation suggests that the formalin-induced nociceptive response precedes COX-2 protein de novo synthesis and may therefore be unresponsive to COX-2 inhibition. Considering the results obtained with the formalin model it may be hypothesized that the efficacy of celecoxib in early injury evoked pain may be less than that of unselective NSAIDs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00613.x

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Digitale Medien

Pacemaker Therapy in Isolated Congenital Complete Atrioventricular Block (2002)

BREUR, JOHANNES M.P.J. ; UDINK Ten Cate, FLORIS E.A. ; KAPUSTA, LIVIA ; [weitere]

Oxford, UK : Blackwell Futura Publishing, Inc.

Pacing and clinical electrophysiology 25 (2002), S. 0

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ISSN: 1540-8159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: BREUR, J.M.P.J., et al.: Pacemaker Therapy in Isolated Congenital Complete Atrioventricular Block. The aim of this study was to evaluate the effect of pacemaker (PM) therapy in patients with isolated congenital complete atrioventricular block (CCAVB). Patients with CCAVB eventually qualify for PM implantation, however, timing remains controversial. Retrospective evaluation of left ventricular end-diastolic diameter (LVEDD), shortening fraction (SF), and cardiothoracic ratio (CTR) in 149 CCAVB patients, before, at, and after PM implantation was carried out. LVEDD shows an average increase of 0.48%/month in non-PM patients, and an average decrease of 0.88%/month in PM patients. SF shows an average increase of 0.10%/month in non-PM, and an average decrease of 0.32%/month in PM patients. CTR shows an average increase of 0.02%/month in non-PM, and an average decrease of 0.19%/month in PM patients. The difference between the non-PM and PM groups is significant (P = 0.05) for all variables. Symptomatic patients show no significant change in LVEDD after PM therapy (from 66.5% before to 68.5% after PM therapy). Asymptomatic patients do show a significant (P 〈 0.001) decrease in LVEDD after PM therapy (from 78.4% before to 73.3% after PM therapy). CTR does not differ significantly between symptomatic and asymptomatic patients before PM therapy (58% and 57%, respectively). CTR does differ significantly (P 〈 0.001) between symptomatic and asymptomatic patients after PM therapy (52% and 48%, respectively). Heart size and SF are increased in most patients with isolated CCAVB. PM implantation is associated with a decrease in heart size and normalization of SF in most patients. Indications for PM therapy in children may require reevaluation in asymptomatic patients with increased cardiac size and decreased cardiac function.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1460-9592.2002.01685.x

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