GLORIA

GEOMAR Library Ocean Research Information Access

You have 0 saved results.
Mark results and click the "Add To Watchlist" link in order to add them to this list.
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Springer  (14)
  • American Chemical Society  (2)
  • American Heart Association (AHA)
  • Oxford University Press
  • Periodicals Archive Online (PAO)
  • 2010-2014
  • 1985-1989  (9)
  • 1975-1979  (3)
  • 1970-1974  (3)
  • 1925-1929  (1)
  • 1987  (9)
  • 1976  (3)
  • 1973  (3)
  • 1928  (1)
Document type
Publisher
Years
  • 2010-2014
  • 1985-1989  (9)
  • 1975-1979  (3)
  • 1970-1974  (3)
  • 1925-1929  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 428-432 
    ISSN: 1432-1440
    Keywords: Rare cause of primary aldosteronism ; Hypokalemic hypertension ; Diagnostic procedure ; Treatment of malignant adrenal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 58-year-old white woman with hypertension and severe hypokalemia was found to have a carcinoma of the left adrenal gland. Plasma renin activity was constantly under the normal limit, while plasma aldosterone levels were pathologically elevated. Plasma cortisol (8:00 a.m.) and excretion rates of urinary free cortisol were within the normal range. After an adrenalectomy, relapsing excessive aldosterone secretion was successfully treated with opDDD (Lysodrene). Ten months after the diagnosis was established, the patient died from a bleeding liver metastasis.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1440
    Keywords: Cushing-Syndrom ; Hypertonie ; Renin-Aktivität ; Aldosteronismus ; Cushing's syndrome ; Hypertension ; Renin activity ; Aldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To investigate the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome two patients with hypercorticism were infused with 20 mg saralasin (1-sar-8-alaangiotensin II) over a period of 30 minutes under constant blood pressure control. In addition, one patient with primary aldosteronism, an established form of mineralocorticoid hypertension, served as control. Neither in the two patients with Cushing's syndrome nor in the patient with primary aldosteronism could a blood pressure lowering effect of saralasin be observed. In the two patients with hypercorticism both renin activity and plasma aldosterone increased during saralasin infusion. The patient with primary aldosteronism only showed a weak increase in plasma aldosterone concentration. These results seem to exclude an important role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome. The unresponsiveness of elevated blood pressure to saralasin in the two patients with hypercorticism and in the patient with primary aldosteronism indirectly supports the assumption that in patients with Cushing's syndrome increased mineralocorticoid activity may be the main factor in the pathogenesis of hypertension.
    Notes: Zusammenfassung Um die Bedeutung des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom zu untersuchen, wurden bei 2 Patienten mit Hyperkortizismus 20 mg Saralasin (1-Sar-8-Ala-Angiotensin II) über einen Zeitraum von 30 min unter ständiger Blutdruckkontrolle infundiert. Zusätzlich diente ein Patient mit primärem Aldosteronismus, einer etablierten Form von Mineralokortikoidhochdruck, als Kontrolle. Weder bei den 2 Patienten mit Cushing-Syndrom noch bei dem Patienten mit primärem Aldosteronismus ließ sich ein blutdrucksenkender Effekt des Saralasins nachweisen. Die beiden Patienten mit Hyperkortizismus zeigten unter Saralasin sowohl einen Anstieg der Renin-Aktivität als auch des Plasmaaldosterons. Bei dem Patienten mit primärem Aldosteronismus ließ sich nur ein geringgradiger Anstieg der Plasmaaldosteronkonzentration nachweisen. Diese Ergebnisse sprechen gegen eine wichtige Rolle des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom. Die Unbeeinflußbarkeit des Hochdrucks durch Saralasin bei den beiden Patienten mit Hyperkortizismus und dem Patienten mit primärem Aldosteronismus stützen indirekt die Annahme, daß bei Patienten mit Cushing-Syndrom eine erhöhte Mineralokortikoidaktivität der Hauptfaktor in der Pathogenese der Hypertonie ist.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 50 (1928), S. 3389-3389 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 276 (1976), S. 161-165 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Thermal9Be+ (I=3/2) ions are polarized by direct optical pumping in He buffer gas. Observation of⩼gDF=± 1 transitions yields for the hyperfine splitting frequencyv hfs(9Be+, 1s 2 2s 2 S 1/2)=1250018(5) kHz. The result is discussed with regard to predictions of recent theoretical calculations and of the Fermi-Segré formula for the ground state hfs of the Li isoelectronic sequence.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1435-1463
    Keywords: diazepam ; N-desmethyldiazepam ; endogenous benzodiazepine receptor ligand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Benzodiazepine-binding inhibitory (BBI) activity was detected in aqueous extracts of brain and peripheral tissues of rats. The BBI activity in brain and in adrenals was, at least partially, due to the presence of N-des-methyldiazepam and diazepam as shown by HPLC, UV-spectroscopy and mass spectrometry. In addition, BBI activity was found in standardized rat food, as well as in a variety of cereals and in other nutritive plant products. In wheat grains diazepam and N-desmethyldiazepam could be identified by HPLC and analysis by gas chromatography combined with mass spectrometry. The estimated amounts of the two benzodiazepines present in rat brain and adrenals and in wheat grains were in the low ppb range. Since laboratory contamination was rigorously excluded we conclude that diazepam and N-desmethyldiazepam are naturally occurring compounds. These findings may explain their occurrence in the brain and adrenals of animals.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 155-160 
    ISSN: 1432-1440
    Keywords: Hypertension ; Ca2+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several disturbances of cellular Ca2+ metabolism have been described in essential hypertension and in the spontaneously hypertensive rat. Possibly the elevation of intracellular free Ca2+ concentration in arterial smooth muscle cells is one important step in the pathogenesis of primary hypertension. In most studies a decreased energy-dependent Ca2+ transport has been proposed as a mechanism. However, disturbances in cellular Ca2+ metabolism, which can be exclusively ascribed to essential hypertension, have not yet been found. The cause of altered cellular Ca2+ transport in primary hypertension may either be a genetically determined defect of membrane transport or a still-unidentified humoral factor.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 216 (1973), S. 81-90 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of galactorrhea in an unselected group of 5597 outpatients of our gynaecological department was 0.89%. Only one patient had amenorrhea simultaneously (0.02%). There is no age dependency of galactorrhea during the period of sexual maturity (between the age of 20 and 50). A few cases can be observed in the postmenopause. The percentage of galactorrhea ocouring after a previous pregnancy is extremely small. Based upon the chemical analysis of secretions from galactorrhea and of normal human breast milk it is obvious that the two fluids are not identical. Irregularities of the menstrual cycles are present mainly in the form of monophasic cycles. There is a high incidence of pathological fasting plasma glucose concentrations (approx. 20%). An attempt is made to detect the different causes for galactorrhea. In more than 50% of the patients morphological alterations of the mammary tissue can be found. Six times there were intracanalicular papillomas. A procedure for the diagnosis of an uncomplicated galactorrhea is suggested.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 76 (1987), S. 233-243 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract In the context of Gondwana North Victoria Land forms the Antarctic conjugate terrain to the East Australian Lachlan Fold Belt, where the distinction between S- and I-type granitoids was first worked out (Chappell &White 1974). Thus the area was considered a good testing ground for the hypothesis when the German Antarctic North Victoria Land Expedition (Ganovex) resumed fieldwork there in 1979/80. It was known at that time that there existed a Cambro/Ordovician and a Devonian/Carboniferous granitoid generation, which, in analogy to Australia, were taken to be related to two different orogenetic events. Our geological, petrographical and geochemical investigations, together with radiometric age dating, revealed that this is true only for the older granite generation. The younger generation is in fact anorogenic. At the same time, it became obvious that the S- and I-type classification did not completely fit the observed field data. At this pointPitcher's (1982) subdivision of the I-types into a »Cordilleran« and a »Caledonian« suite offered a solution to account for the observed irregularities. At about the same time, plate tectonic models based on evidence independent from the granite classification were developed for this part of the active Gondwana margin. This offers the opportunity to crosscheck the tectonic environment derived from the granite classification: The characteristics of the older, Cambro/Ordovician granitoids allow a perfect accommodation in the model of an active margin above a subduction zone as derived from other evidence. For the younger (Devonian/Carboniferous) granitoids, however, the postulated tectonic setting (post-collisional uplift and faulting) could not be verified in North Victoria Land. It is concluded thatPitchers classification is applicable in its petrographic and geochemical aspects but that the tectonic environment postulated for the production of »Caledonian« I-type granitoids may not be the same in all investigated areas.
    Abstract: Résumé Dans le contexte du Gondwana, la Terre Victoria est le pendant antarctique de la zone plissée de Lachlan, en Australie Orientale, où la distinction entre granites S et I a été établie pour la première fois (Chappel &White 1974). C'est pourquoi la vérification de cette hypothèse a été portée au programme de l'expédition allemande à la Terre Victoria en 1979–80 (Ganovex). On connaissait à cette époque l'existence d'une génération cambro-ordovicienne et d'une génération dévono-carbonifère de granitoÏdes qui, par analogie avec l'Australie, avaient été rapportées à deux événements orogéniques différents. Nos investigations géologiques, pétrologiques, géochimiques et géochronologiques montrent que cette conclusion n'est vraie que pour les granites de la première génération. La seconde génération est, en fait, anorogénique. Il s'est avéré en mÊme temps que la répartition en types S et I ne correspond pas exactement aux observations de terrain. Par contre, la distinction introduite parPitcher (1982) parmi les granites I entre une série »de Cordillère« et une série »Calédonienne« peut expliquer les irrégularités que nous observons. Environ à cette époque, des modèles géodynamiques basés sur des considérations indépendantes de la classification des granites ont été proposés pour cette partie de la marge active du Gondwana. Ces modèles permettent de recouper les considérations sur l'environnement tectonique des granites, déduites de leur classification: Les caractères des granitoÏdes anciens, cambro-ordoviciens, s'accordent parfaitement au modèle d'une marge active surmontant une subduction. Par contre, pour les granitoÏdes jeunes, dévono-carbonifères, la situation tectonique postulée (soulèvement et fracturation post-collision) n'a pas pu Être confirmée sur la Terre Victoria. En conclusion, la classification dePitcher est applicable dans ses aspects pétrographiques et géochimiques, mais l'environnement tectonique qui préside à la formation de granitoÏdes de type »Calédonien I« n'est pas nécessairement le mÊme dans toutes les régions étudiées.
    Notes: Zusammenfassung Im Gondwana Rahmen bildet Nord Victoria Land das antarktische Pendant zur ostaustralischen Lachlan Mobilzone, wo die Einteilung von Graniten in S- und I-Typen entwickelt wurde (Chappell &White 1974). Deshalb war eine überprüfung dieser neu entwickelten Hypothese eines der Arbeitsziele, als die deutschen Nord Victoria Land Expeditionen (Ganovex) dort 1979 ihre Arbeiten aufnahmen. An den bekannten zwei Granitgenerationen der Region wurden geologische, petrographische und geochemische Untersuchungen sowie Altersbestimmungen durchgeführt, deren Ergebnisse sich folgenderma\en zusammenfassen lassen. Die ältere, kambro-ordovizische Granitfolge steht, analog zur Situation in Australien, in enger Beziehung zu einer bedeutenden Orogenese, während sich zur jüngeren, devonisch-karbonischen Suite kein zugehöriges tektonisches Ereignis finden lie\. Dies steht im Gegensatz zur Situation in Australien/Tasmanien. Die S- und I-Typ Klassifikation, auf Nord Victoria Land angewendet, weist ähnliche Widersprüche auf, wie siePitcher (1982) zur Aufteilung der I-Typen in »kordillere« und »kaledonische« Sippen führten. Plattentektonische Modelle, die in den letzten Jahren für diese Region am mobilen Rand Gondwanas unabhängig von der Granitklassifikation nach geologischen und tektonischen Kriterien entwickelt wurden, erlauben es, die vonPitcher entwickelten tektonischen Bildungsmilieus für verschiedene Granit-Typen zu überprüfen: Die Charakteristiken der älteren (kambro-ordovizischen) Granite erlauben ein widerspruchsloses Einfügen in das aus anderen Kriterien abgeleitete Bild eines aktiven Kontinentalrandes über einer Subduktionszone. Für die jüngeren (devonisch-karbonischen) Granite dagegen, die im Charakter den »kaledonischen« I-TypenPitchers entsprechen, sind die für deren Bildung postulierten Vorgänge, nämlich Hebung und Dehnung nach einer Kollision, in Nord Victoria Land nicht erkennbar. Demnach erscheint zwar die KlassifikationPitchers sinnvoll, da sie in ihrer petrographisch-geochemischen Charakterisierung nachvollziehbar ist, aber das abgeleitete tektonische Milieu für die Bildung der »kaledonischen« Typen bedarf einer weiteren überprüfung.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 30 (1987), S. 100-103 
    ISSN: 1432-0428
    Keywords: Fetal rats ; skeletal growth ; streptozotocin ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For largely unknown reasons severe or moderate diabetes of pregnant rats results in pronounced fetal growth retardation. Therefore, some skeletal growth parameters of fetal rats from streptozotocin diabetic mothers were studied in vivo and in vitro. Two days post conception rats were intravenously injected with 65 mg/kg body weight streptozotocin. On day 20 post conception 8 normal and 8 diabetic rat mothers received 5 μCi 3-H thymidine intraperitoneally. One day later the experiments were terminated. Fetal body weight and body length were significantly (p〈0.05–0.001) reduced in the hyperglycaemic rats compared to normal rats, as was the thymidine incorporation into rib cartilage (p〈0.02). In the cell culture colony formation from isolated chondrocytes of normal and hyperglycaemic fetuses was determined. Proinsulin, insulin (62.5–250 ng/ml), insulin-like growth factor I and II (6.25–25 ng/ml) significantly (p〈0.05–0.001) augmented colony formation in a dose-dependent manner, with the somatomedins being 8 times more effective than proinsulin or insulin. Isolated chondrocytes from hyperglycaemic compared to normal fetuses formed significantly (p〈0.05–0.001) fewer colonies in the basal state and in response to all 4 hormones. The results confirm the growth retardation of fetuses from diabetic rat mothers. A reduced responsiveness of chondrocytes from hyperglycaemic fetuses to various growth factors could be demonstrated as compared to cells from normal fetuses.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...