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1

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The effect of saralasin (1-Sar-8-Ala-Angiotensin II) on blood pressure in patients with cushing's syndrome (1976)

Vetter, W. ; Vetter, H. ; Beckerhoff, R. ; [et al.]

Springer

Journal of molecular medicine 54 (1976), S. 661-663

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ISSN: 1432-1440

Keywords: Cushing-Syndrom ; Hypertonie ; Renin-Aktivität ; Aldosteronismus ; Cushing's syndrome ; Hypertension ; Renin activity ; Aldosteronism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Summary To investigate the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome two patients with hypercorticism were infused with 20 mg saralasin (1-sar-8-alaangiotensin II) over a period of 30 minutes under constant blood pressure control. In addition, one patient with primary aldosteronism, an established form of mineralocorticoid hypertension, served as control. Neither in the two patients with Cushing's syndrome nor in the patient with primary aldosteronism could a blood pressure lowering effect of saralasin be observed. In the two patients with hypercorticism both renin activity and plasma aldosterone increased during saralasin infusion. The patient with primary aldosteronism only showed a weak increase in plasma aldosterone concentration. These results seem to exclude an important role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome. The unresponsiveness of elevated blood pressure to saralasin in the two patients with hypercorticism and in the patient with primary aldosteronism indirectly supports the assumption that in patients with Cushing's syndrome increased mineralocorticoid activity may be the main factor in the pathogenesis of hypertension.

Notes: Zusammenfassung Um die Bedeutung des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom zu untersuchen, wurden bei 2 Patienten mit Hyperkortizismus 20 mg Saralasin (1-Sar-8-Ala-Angiotensin II) über einen Zeitraum von 30 min unter ständiger Blutdruckkontrolle infundiert. Zusätzlich diente ein Patient mit primärem Aldosteronismus, einer etablierten Form von Mineralokortikoidhochdruck, als Kontrolle. Weder bei den 2 Patienten mit Cushing-Syndrom noch bei dem Patienten mit primärem Aldosteronismus ließ sich ein blutdrucksenkender Effekt des Saralasins nachweisen. Die beiden Patienten mit Hyperkortizismus zeigten unter Saralasin sowohl einen Anstieg der Renin-Aktivität als auch des Plasmaaldosterons. Bei dem Patienten mit primärem Aldosteronismus ließ sich nur ein geringgradiger Anstieg der Plasmaaldosteronkonzentration nachweisen. Diese Ergebnisse sprechen gegen eine wichtige Rolle des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom. Die Unbeeinflußbarkeit des Hochdrucks durch Saralasin bei den beiden Patienten mit Hyperkortizismus und dem Patienten mit primärem Aldosteronismus stützen indirekt die Annahme, daß bei Patienten mit Cushing-Syndrom eine erhöhte Mineralokortikoidaktivität der Hauptfaktor in der Pathogenese der Hypertonie ist.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01469145

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2

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Mineralstoffe und Aminosäuren in den Körnern der neu kultivierten „Pseudo-Getreide“-ArtAmaranthus hypochondriacus (1994)

Vetter, János

Springer

European food research and technology 198 (1994), S. 284-286

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ISSN: 1438-2385

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Description / Table of Contents: Zusammenfassung Die Mineralstoffe und die Aminosäu-rezusammensetzung der Samen von kultiviertemAmaranthus hypochondriacus wurden untersucht. Die Konzentrationen der Mineralstoffe inAmaranthus-Körnern sind ähnlich denen in Weizen oder auch der Erbse. Die Standorte der Pflanzen haben allerdings einen bedeutenden Einfluß. Der Gesamt-Aminosäuregehalt und besonders die Menge der essentiellen Aminosäuren (Lysin, Arginin usw.) sind höher als in den Samen von Weizen und Mais. Die kultiviertenAmaranthus-Arten haben deshalb nicht nur vorteilhafte ökologische (Dürrefestigkeit, Anspruchslosigkeit), sondern auch positive ernährungsphysiologische Eigenschaften.

Notes: Abstract The mineral elements and the amino acids in seeds of cultivatedAmaranthus hypochondriacus were studied. The following conclusions can be made: 1. The contents of minerals inAmaranthus seed are similar to those of wheat and (except of a few elements: P, K) of pea. The habitats of plants, especially the soil conditions effect importantly on minerals.-2. The total amino acid content and mainly the rate of essential amino acids (lysine, arginine etc) are higher than those in seeds of wheat and maize and this fact create the importance of cultivation and utilisation of this plant. The cultivatedAmaranthus species have favourable ecological properties (drought resistence, wantlessness) too.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01193175

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3

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Kalium-Gehalt von eßbaren Wildpilzen (1994)

Vetter, János

Springer

European food research and technology 198 (1994), S. 33-35

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ISSN: 1438-2385

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Description / Table of Contents: Zusammenfassung Der Kaliumgehalt von eßbaren höheren Pilzarten beträgt durchschnittlich 34,35 g/kg−1 Trockenmasse (Standardabweichung: 12,91), er ist somit bedeutend und stellt eine wertvolle K-Quelle für die menschliche Ernährung dar. Die Kalium-Konzentration der Pilze ist relativ konstant. Eine Akkumulation von Kalium wird in den Proben nicht gefunden. Diese Tatsache wird durch Ergebnisse anderer Autoren bestätigt.

Notes: Abstract The average potassium content of edible higher mushroom species is 34,35 g/kg−1 dry matter (SD:12,91) and thus an important and valuable K-source for human diet. The K-concentration of mushrooms is relatively constant. An accumulation of potassium in the mushroom samples analysed was not found. This fact is confirmed by the results of other authors, too.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01195279

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4

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Hyperfine structure measurement of the9Be+ 22 s 1/2 ground state by optical pumping (1976)

Vetter, J. ; Ackermann, H. ; Putlitz, G. zu ; [et al.]

Springer

The European physical journal 276 (1976), S. 161-165

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ISSN: 1434-601X

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Notes: Abstract Thermal9Be+ (I=3/2) ions are polarized by direct optical pumping in He buffer gas. Observation of⩼gDF=± 1 transitions yields for the hyperfine splitting frequencyv hfs(9Be+, 1s 2 2s 2 S 1/2)=1250018(5) kHz. The result is discussed with regard to predictions of recent theoretical calculations and of the Fermi-Segré formula for the ground state hfs of the Li isoelectronic sequence.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01412094

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5

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Die Kupfer-, Mangan- und Zink-Gehalte einiger eßbarer Großpilzarten (1994)

Vetter, János

Springer

European food research and technology 198 (1994), S. 469-472

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ISSN: 1438-2385

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Description / Table of Contents: Zusammenfassung 56 Proben eßbarer, verbreiteter Großpilzarten wurden auf Kupfer-, Mangan- und Zink-Gehalte analysiert. Die durchschnittliche Kupferkonzentration der Pilzproben (56,16 mg/kg Trockenmasse) ist relativ hoch (im Vergleich zu grünen Pflanzen), einige Pilzgruppen (Agaricus- undMacrolepiota-Arten) zeigen Kupfer-Akkumulation (bis 226 mg/kg). Ausgesprochene Mangan-Akkumulation wurde beiLepista nebularis undPluteus atricapillus nachgewiesen. Der Zink-Gehalt der Pilzproben (duchschnittlich: 104,1 mg/kg, zwischen 7,71 mg/kg (Lepista nebularis) und 194,3 mg/kg (Agaricus silvaticus) ist relativ ausgeglichen, Akkumulationser- scheinungen wurden nicht festgestellt.

Notes: Abstract Fifty six samples of edible, wide-spread species of higher fungi were analysed for copper-, manganese and zinc-contents. The average copper concentration of the samples is high (56,16 mg/kg dry mass) as compared to the green plants. Some groups of fungi (Agaricus andMacrolepiota species) are considerable copper-accumulators (until 226 mg/kg DM). Pronounced accumulation of manganese was reported in the case ofLepista nebularis andPluteus atricapillus. The zinc-content of fungi (average: 104,1 mg/kg DM, between 7,71 mg/kg (Lepista nebularis) and 194, 3 mg/kg (Agaricus silvaticus) is relatively balanced, accumulation were not established.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01192842

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6

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Morning versus evening administration of nifedipine gastrointestinal therapeutic system in the management of essential hypertension (1994)

Greminger, P. ; Suter, P. M. ; Holm, D. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 864-869

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ISSN: 1432-1440

Keywords: Nifedipine gastrointestinal therapeutic system ; Essential hypertension ; Ambulatory blood pressure measurement

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The nifedipine gastrointestinal therapeutic system (GITS) is a recently developed controlled-release formulation for once-a-day dosing. We evaluated the influence of morning versus evening administration of the drug in a randomized double-blind cross-over study including 15 essential hypertensives. Five patients had to be excluded from blood pressure analysis because of noncompliance (three cases) or intolerable side effects (two cases). To assess the exact duration of the antihypertensive efficacy noninvasive automatic ambulatory blood pressure monitoring was performed. After a placebo period patients were given 30 mg nifedipine GITS either at 1000 or 2200 hours. Twenty-four-hour systolic and diastolic blood pressure profiles documented a sustained antihypertensive effect of both nifedipine regimens throughout the whole period without affecting the circadian rhythm. Statistical analysis revealed no significant difference between morning and evening administration. Two patients stopped their medication because of intolerable side effects (fatigue and muscle cramps, respectively). Two more cases suffered from mild reversible headache which provoked no discontinuation of the drug. In conclusion our results document a sustained antihypertensive efficacy of 30 mg nifedipine GITS in patients with moderate essential hypertension. Time of administration has no impact on day- and nighttime blood pressure control.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00190742

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7

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Evidence for cardiovascular remodeling in a patient with Bartter's syndrome (1994)

Schmitz, U. ; Ko, Y. ; Becher, H. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 874-877

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ISSN: 1432-1440

Keywords: Bartter's syndrome ; Cardiovascular remodeling ; Diastolic dysfunction ; Intima/media complex

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In a 56-year-old normotensive white male subject with a 12-year history of hypokalemic alkalosis, hyperreninemia, and aldosteronism, the diagnosis of Bartter's syndrome was established on the basis of an impaired maximal renal diluting capacity and decreased distal fractional chloride absorption [CH2O/(CH2O + CCl)]. Negative urine analysis for diuretics suggested that this renal tubular defect was not secondary to diuretic (ab)use. In this normotensive patient with hyperreninemia and secondary aldosteronism, significant cardiovascular remodeling could be observed. Thus, in spite of normal arterial blood pressure and normal left ventricular systolic function (ejection fraction 〉 70%), impaired left ventricular diastolic function was observed using pulsed-wave Doppler echocardiography. Moreover, duplex analysis of the common carotid artery revealed significant intima-media hypertrophy with an average intima-media diameter of 0.9 mm (normal ≤ 0.6 mm). Also, forearm venous occlusion plethysmography revealed an abnormally high minimal forearm vascular resistance following a 10-min period of forearm ischemia handgrip exercise suggesting remodeling within the peripheral arterioles. Thus, in a patient with Bartter's syndrome and activated neurohormonal systems such as the renin-angiotensin system, cardiac and vascular remodeling can be observed in the absence of hypertension. In analogy to the results of experimental studies showing that angiotensin II and noradrenaline act as growth factors on cardiac and vascular cells, cardiovascular remodeling present in our patient with Bartter's syndrome may be explained by increased activity of angiotensin II and/or noradrenaline.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00190744

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8

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Primary aldosteronism: difference in clinical presentation and long-term follow-up between adenoma and bilateral hyperplasia of the adrenal glands (1994)

Jeck, T. ; Weisser, B. ; Mengden, T. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 979-984

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ISSN: 1432-1440

Keywords: Adenoma ; Aldosterone ; Adrenalectomy ; Gynecomastia ; Hyperaldosteronism ; Hyperplasia ; Spironolactone

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Since 1974 primary aldosteronism has been diagnosed in 71 patients in our outpatient clinic. Thirty-four patients had a unilateral aldosterone-producing adenoma, whereas bilateral adrenal hyperplasia was diagnosed in 37 patients. Although at the time of diagnosis the mean potassium values were lower and mean aldosterone levels were higher in patients with an adenoma, as compared to those with bilateral hyperplasia, these laboratory data did not allow us to differentiate between the two leading causes of primary aldosteronism in the individual patient due to pronounced overlap of laboratory values between the two groups. During the first few years, a successful differential diagnosis was made by adrenal phlebography and separate sampling of plasma aldosterone in both adrenal veins; later non-invasive imaging techniques such as computed tomography and radionuclide scanning were used. The best results were obtained in patients with adenoma who underwent adrenalectomy. Fifty-six percent of these patients were clinically and biochemically cured; 28% were improved and had normal blood pressure values during drug treatment. In contrast, patients with bilateral hyperplasia were treated pharmacologically, but only in half of the patients could normal blood pressure values be achieved. Two thirds of the male patients developed gynecomastia during spironolactone treatment. As expected, unilateral adrenalectomy was unsuccessful in the 7 patients with bilateral hyperplasia who underwent surgery. Our results confirm that surgical treatment of adrenal adenomas and drug treatment of bilateral hyperplasias are the appropriate therapy in primary aldosteronism. A differential diagnosis cannot be made on the basis of clinical and non-invasive laboratory data alone; imaging techniques have to be included in the diagnostic process. The long-term clinical outcome was more favorable in patients with an adrenal adenoma that can be removed surgically than in patients with idiopathic hyperplasia of both adrenal glands.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00577740

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9

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Plasma lipids and lipoproteins and essential hypertension (1994)

Flesch, M. ; Sachinidis, A. ; Ko, Y. D. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 944-950

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ISSN: 1432-1440

Keywords: Hypertension ; Low density lipoprotein ; Apo B ; Cholesterol ; Very low density lipoprotein ; Triglycerides ; Lipoprotein (a)

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P ≤ 0.001), Apo B serum levels (P ≤ 0.001), serum triglyceride levels (P ≤ 0.05) and VLDL serum levels (P ≤ 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00577733

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Iron-deficiency anemia as the sole manifestation of celiac disease (1994)

Schmitz, U. ; Ko, Y. ; Seewald, S. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 519-521

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ISSN: 1432-1440

Keywords: Iron-deficiency anemia ; Celiac disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We report on a 40-year-old woman with a 2-year history of iron-deficiency anemia of unknown origin. Repeated endoscopic investigations in the past had revealed no abnormality of the gastrointestinal system on macroscopic examination. Oral iron supplementation was shown to have no effect on serum iron levels and had no influence on the anemia. Upper gastrointestinal endoscopy performed at our hospital confirmed normal macroscopic findings. However, jejunal biopsies revealed subtotal villous atrophy of the mucosa of the small intestine. A strict gluten-free diet led to an increase in serum iron, resolution of the anemia, and restitution of normal mucosal architecture. Thus iron-deficiency anemia may be the lone manifestation of celiac disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00207481

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