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  • Plasma renin concentration  (2)
  • Cystinuria Pathogenesis  (1)
  • Dark metabolism  (1)
  • Key words Activated protein C  (1)
  • Springer  (5)
  • American Heart Association (AHA)
  • American Institute of Physics (AIP)
  • Macmillan Magazines Ltd.
  • Nature Publishing Group (NPG)
  • Oxford University Press
  • 2010-2014
  • 1995-1999  (2)
  • 1970-1974  (3)
  • 1955-1959
  • 1870-1879
  • 1998  (2)
  • 1972  (3)
  • 1956
  • 1871
Document type
Keywords
Publisher
  • Springer  (5)
  • American Heart Association (AHA)
  • American Institute of Physics (AIP)
  • Macmillan Magazines Ltd.
  • Nature Publishing Group (NPG)
    • +
Years
  • 2010-2014
  • 1995-1999  (2)
  • 1970-1974  (3)
  • 1955-1959
  • 1870-1879
Year
  • 1998  (2)
  • 1972  (3)
  • 1956
  • 1871
  • 1
    Electronic Resource
    Electronic Resource
    NAD-dependent malate dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase isoenzymes play an important role in dark metabolism of various plastid types (1998)
    Springer
    Planta 205 (1998), S. 359-366 
    Details
    ISSN: 1432-2048
    Keywords: Key words:Capsicum (fruit plastids) ; Dark metabolism ; Glyceraldehyde 3-phosphate dehydrogenase ; Malate dehydrogenase ; Malate valve ; Spinacia (chloroplasts)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Chloroplasts isolated from spinach (Spinacia oleracea L.) leaves and green sweet-pepper (Capsicum annuum L. var. grossum (L.) Sendt.) fruits contain NADP-dependent malate dehydrogenase (MDH; EC 1.1.1.82) and the bispecific NAD(P)-glyceraldehyde 3-phosphate dehydrogenase (GAPDH; EC 1.2.1.13). The NADP-dependent MDH and GAPDH are activated in the light, and inactive in the dark. We found that chloroplasts possess additional NAD-dependent MDH activity which is, like the NAD-dependent GAPDH activity, not influenced by light. In heterotrophic chromoplasts from red sweet-pepper fruits, the NADP-dependent MDH and the NAD(P)-GAPDH isoenzymes disappear during the developmental transition and only NAD-specific isoforms are found. Spinach chloroplasts contain both NAD/H and NADP/H at significant concentrations. Measurements of the pyridine dinucleotide redox states, performed under dark and various light conditions, indicate that NAD(H) is not involved in electron flow in the light. To analyze the contribution of NAD(H)-dependent reactions during dark metabolism, plastids from spinach leaves or green and red sweet-pepper fruits were incubated with dihydroxyacetone phosphate (DHAP). Exogenously added DHAP was oxidized into 3-phosphoglycerate by all types of plastids only in the presence of oxaloacetate, but not with nitrite or in the absence of added electron acceptors. We conclude that the NAD-dependent activity of GAPDH is essential in the dark to produce the ATP required for starch metabolism; excess electrons produced during triose-phosphate oxidation can selectively be used by NAD-MDH to form malate. Thus NADPH produced independently in the oxidative pentose-phosphate pathway will remain available for reductive processes inside the plastids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004250050331
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bestimmung der Plasma-Renin-Konzentration mittels Radioimmunoassays für Angiotensin I (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 702-705 
    Details
    ISSN: 1432-1440
    Keywords: Plasma renin concentration ; radioimmunoassay ; angiotensin I ; Plasma-Renin-Konzentration ; radioimmunologischer Nachweis ; Angiotensin I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Radioimmunoassay für Angiotensin I und seine Anwendung für die Messung der Reninkonzentration im Plasma werden beschrieben. Die zur Herstellung von Angiotensinantikörpern und radioaktiv markiertem Angiotensin sowie zur Trennung von gebundenem und freiem Hormon benutzten Verfahren werden mitgeteilt. Die Empfindlichkeit der Methode erlaubt den Nachweis von zwanzig Pikogramm Angiotensin I. Zur Messung der Reninkonzentration wurde substratfreies Plasma mit Schafsubstrat im Überschuß versetzt und in Anwesenheit von Inhibitoren von „converting enzyme“ und Angiotensinasen bei 37°C inkubiert. Das gebildete Angiotensin wurde in 20 µl des proteinfreien Inkubationsgemisches bestimmt. Die initiale Geschwindigkeit der Angiotensinbildung wurde zur Berechnung der Reninkonzentration herangezogen. Als eine Einheit wurde die Reninmenge definiert, die ein Nanogramm Angiotensin I pro Stunde Inkubation bildet. Normalwerte unter kontrollierter natriumreicher und natriumarmer Diät wurden ermittelt. Die Empfindlichkeit der Methode erlaubt die Messung der Reninkonzentration im Plasma von Patienten mit primärem Aldosteronismus.
    Notes: Summary A radioimmunoassay for angiotensin I and its application to the measurement of plasma renin concentration are described. Outlined are the methods which were used to elicite antibodies against angiotensin I, to iodinate angiotensin I with iodine125, and to separate free from antibody-bound hormone. The method is sensitive enough to detect 20 picogrammes of angiotensin I. Substrate-free plasma was mixed with excess of sheep substrate. The mixture was incubated at 37°C in the presence of inhibitors of converting enzyme and angiotensinases. The generated angiotensin I was measured in 20 µl of the protein-free incubation mixture. The initial velocity of angiotensin generation was used to calculate the renin concentration. One unit was defined as the amount of renin which generates one nanogram of angiotensin per hour. Normal values of plasma renin concentration were obtained both during sodium loading and sodium depletion. The sensitivity of the method allows the measurement of plasma renin in patients with primary aldosteronism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495529
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Die Plasma-Renin-Konzentration beim primären Hyperaldosteronismus unter Suppressions- und Stimulationsbedingungen (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 783-786 
    Details
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Plasma renin concentration ; Primärer Hyperaldosteronismus ; Plasma-Renin-Konzentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 13 Patienten mit einem primären Hyperaldosteronismus wurde die Plasma-Renin-Konzentration unter Stimulations- und unter Suppressionsbedingungen gemessen. Eine hochempfindliche Methode zur Reninmessung, die sich eines Radioimmunoassays für Angiotensin I bediente, wurde verwandt. Bei jedem der Patienten ließ sich die Reninkonzentration im Plasma gut messen. Die Werte lagen hochsignifikant unter den Normbereichen, die unter denselben Bedingungen ermittelt worden waren. Am eindrücklichsten war der Unterschied zwischen normalen und pathologischen Werten unter Stimulationsbedingungen. Nach Kochsalzentzug stieg die Reninkonzentration zwar bei nahezu allen Patienten signifikant an, der Anstieg war jedoch subnormal, gemessen an dem gesunden Kontrollkollektiv. Renin ist auch beim primären Aldosteronismus im Plasma vorhanden und reagiert auf Stimulation qualitativ regelrecht, quantitativ jedoch subnormal.
    Notes: Summary Plasma renin concentration (PRC) was measured in thirteen patients with primary aldosteronism during high and low sodium intake. A highly sensitive method using a radioimmunoassay for angiotensin I was applied for the determinations of PRC. PRC was detectable in each patient. The values obtained were significantly lower than the normal ranges which were assessed under the same conditions. Most impressive was the difference between normal and pathological values during sodium deprivation. PRC rose in almost each patient after several days of dietary sodium restriction. The increase was subnormal, however, when compared with normal controls. Renin is present in plasma of patients with primary aldosteronism. It responds qualitatively normally, but quantitatively subnormally when stimulated by sodium deprivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490305
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Increased rate of factor V Leiden mutation in patients with cerebral venous thrombosis (1998)
    Springer
    Journal of neurology 245 (1998), S. 149-152 
    Details
    ISSN: 1432-1459
    Keywords: Key words Activated protein C ; resistance ; Thrombophilia ; Coagulation system ; Stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the association between cerebral venous thrombosis and hereditary resistance to activated protein C (APC) in 12 consecutive German patients with non-fatal cerebral venous thrombosis and in 187 controls without a history of thrombotic disorder. Three patients (25%) had a mutation in the factor V Leiden gene against only one subject in the control group. This difference was significant (P〈0.05), with an odds ratio of 11.7 (1.5–87 ; 95% confidence interval). Two patients carrying the mutation had additional common risk factors for thrombosis, and 2 had a positive family history of thromboembolism. We conclude that inherited APC resistance by a mutation in factor V Leiden is an important risk factor in non-fatal cerebral venous thrombosis. We recommend testing for APC resistance and, if abnormal for factor V Leiden mutation in patients with cerebral venous thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050195
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  • 5
    Electronic Resource
    Electronic Resource
    The tubular reabsorption ofl-cystine andl-cysteine (1972)
    Springer
    Pflügers Archiv 337 (1972), S. 277-284 
    Details
    ISSN: 1432-2013
    Keywords: Renal Tubule ; Microperfusion ; Cystine Reabsorption ; Arginine Reabsorption ; Cystinuria Pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In microperfusion experiments the reabsorption of14C-labelledl-cystine,l-cysteine, andl-arginine from rat proximal tubule was measured, and the transport interaction of these amino acids and some derivatives was tested. The following results were obtained: 1. l-arginine,l-lysine, andl-cysteine inhibitedl-cystine reabsorption. 2. Glycine, agmantine, and 2,6-diaminopimelic acid showed no influence onl-cystine reabsorption. 3. l-cysteine reabsorption was inhibited byl-arginine, but not by glycine. 4. l-cysteine and 2,6-diaminopimelic acid were unable to influence reabsorption ofl-arginine. From these results and some observations reported in the literature, the following concept is put forward for discussion.l-arginine,l-lysine andl-ornithine may be reabsorbed by two separate mechanisms in the proximal tubule.l-cystine may use only one of these ways. Here, it is possible thatl-cystine is transported asl-cysteine. This concept may find relevance in the explanation of the pathogenesis of cystinuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586645
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    Paper (German National Licenses)
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