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  • Springer  (19)
  • American Heart Association (AHA)
  • Institute of Physics Publishing (IOP)
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  • Oxford University Press
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  • 2010-2014
  • 1990-1994  (15)
  • 1975-1979  (3)
  • 1970-1974
  • 1915-1919  (1)
  • 1994  (15)
  • 1976  (3)
  • 1917  (1)
  • 1871
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  • 2010-2014
  • 1990-1994  (15)
  • 1975-1979  (3)
  • 1970-1974
  • 1915-1919  (1)
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  • 11
    ISSN: 1432-1440
    Keywords: Cell volume regulation ; Hypertonicity ; Lymphocytes ; Na+/H+ antiport ; Saline infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Na+/H+ antiport is a membrane transport protein that extrudes intracellular protons in exchange for extracellular sodium. Some details of its physiological and pathophysiological role remain poorly defined. Experimental evidence suggests that the antiporter is involved in the regulation of cell volume. In the present study, we therefore investigated the activity of the lymphocyte Na+/H+ antiport in nine healthy volunteers following acute hypertonic (2.5%) saline infusion (4 mmol NaCl/kg over 120 min). Antiport activity was measured after acidifying the cells with Na+ propionate (5–40 mM) using the fluorescent dye bis-carboxyethyl carboxyfluorescein. Hypertonic saline induced significant increases in plasma osmolality (308.4±2.3 vs. 293.5±2.7 mOsm/kg; P〈0.01), serum Na+ (150.8±3.7 vs. 138.9±0.5 mmol/kg; P〈0.01), and Cl− concentrations (118.0±3.9 vs. 101.1±1.0 mmol/kg; P〈0.01). Extracellular hypertonicity was followed by a stimulated activity of the lymphocyte Na+/H+ antiport with an increase in the apparent V max values from 2.44±0.16 to 3.27±0.34 10−3 s−1 (P〈0.01) and a slight rise in pK from 6.81±0.03 to 6.87±0.03 (P〈0.05) after hypertonic saline. In addition to antiport activation, cytosolic alkalinization was observed with cytosolic pH values averaging 6.90±0.02 before and 6.99±0.02 (P〈0.01) after hypertonic saline. Our results show for the first time that acute extracellular hypertonicity in man due to hypertonic NaCl loading is associated with a stimulated lymphocyte Na+/H+ antiport activity and cytosolic alkalinization.
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  • 12
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Flatfishes of Monterey Bay, central California, undergo species replacements with increasing depth along a transect from 100 m on the continental shelf down to a depth of 1400 m on the continental slope. The Dover sole, Microstomus pacificus, differs from the other local flatfish species by undergoing an extensive ontogenetic vertical migration, occupying all depth zones at different life stages, and having its maximum spawning biomass in the oxygen minimum zone between 600 and 1000 m. Size-activity relationships and depth-activity relationships for the glycolytic enzyme lactate dehydrogenase (LDH) and for two enzymes associated with aerobic metabolism, malate dehydrogenase and citrate synthase (CS), were examined in white-muscle tissue of shallow-living, deep-living and ontogenetically-migrating species. Scaling coefficients (b) for weight-specific enzyme activity (log activity)=a+b (log wet weight), varied in sign as well as magnitude for fishes living at different depths. In the shallow-living California halibut Paralichthys californicus, LDH scaled positively (0.39) and CS scaled negatively (-0.15) with size, a pattern observed previously for most shallow-water fish species. The permanently deep-living species, the deepsea sole Embassichthys bathybius, differed in that both LDH and CS scaled strongly negative (-2.0 and-1.5, respectively). For the ontogenetically migrating Dover sole Microstomus pacificus, there was a shelf-slope transition. For the shelf specimens (≤200 m), LDH scaled positive (0.11) and CS negative (-0.29) and for the slope specimens (≥400 m), LDH scaled negative (-0.65) and CS strongly negative (-0.63). Rex sole, Glyptocephalus zachirus, showed a similar shelf-slope transition. Intraspecific depth-enzyme activity differences were not incremental, but changed abruptly between the continental shelf stations (100 to 200 m) and the continental slope (400 to 1400 m). Based on comparisons with laboratory-maintained individuals, the decline in the metabolic capacity of the white muscle of Dover sole is a phenotypic response to the low food and oxygen conditions of the continental slope. Contrary to expectation, anaerobic capacity (LDH activity) decreased in response to low oxygen conditions, suggesting that in a permanently hypoxic environment such as the oxygen minimum zone the metabolic strategy may be to not incur an oxygen debt that would be difficult to pay back.
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  • 13
    ISSN: 1432-1440
    Keywords: Akute β-Rezeptorenblockade ; Hypertension ; Renin ; Aldosteron ; Tag-Nacht-Rhythmus ; Acute β-receptor blockade ; Hypertension ; Renin ; Aldosterone ; Day-night rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of acute (intravenous) β-adrenergic blockade with propranolol or pindolol on arterial pressure (BP), plasma renin activity (PRA), and plasma concentration of aldosterone (PA) was evaluated in 20 essential hypertensive men. BP, PRA and PA were determined during continuous recumbency overnight (8 p.m. to 6 a.m.) every 30 min. Two groups of patients were observed. Patients of group I exhibited a characteristic day-night rhythm of PRA with low values before midnight and large increases early in the morning. Conversely, no rhythm and very low PRA values were observed in patients of group II. BP was higher in group II than in group I. In group I following intravenous propranolol or pindolol, BP fell within minutes and levels as well as rhythms of PRA were converted to those of group II without treatment. In group II day-night profiles of PRA and BP remained unchanged. Rhythm and concentration of PA in the two groups were not influenced by either drug. In 4 patients of group I infusion of angiotensin II inhibitor did not lower BP. The observations suggest that in the two groups dissimilarities in rhythms of PRA as well as in BP responses to β-blockade may reflect differences in neuro-adrenergic tone.
    Notes: Zusammenfassung Der Einfluß einer akuten (intravenösen) β-Rezeptorenblockade mit Propranolol oder Pindololauf den Blutdruck (RR), die Plasma-Reninaktivität (PRA) und die Plasma-Aldosteronkonzentration (PA) wurde bei 20 Männern mit essentieller Hypertension untersucht. RR, PRA und PA wurden am liegenden Patienten nachts (20.00–6.00 Uhr) alle 30 min bestimmt. Zwei Gruppen von Patienten konnten unterschieden werden: Patienten der Gruppe I wiesen einen charakteristischen Tag-Nacht-Rhythmus in der Plasma-Reninaktivität auf, mit niedrigen Werten vor Mitternacht und hohen Werten am frühen Morgen. Im Gegensatz hierzu hatten die Patienten der Gruppe II sehr niedrige PRA-Werte; ein Rhythmus für PRA ließ sich nicht nachweisen. RR war höher in der Gruppe II als in Gruppe I. Nach Infusion von Propranolol oder Pindolol kam es in der Gruppe I zu einem schnellen RR-Abfall. Das Verhalten des Tag-Nacht-Profils für PRA war nach der β-Blockade vergleichbar mit demjenigen der Gruppe II vor der β-Blockade. In der Gruppe II blieben RR und Tag-Nacht-Profil von PRA unter β-Blockade unverändert. Rhythmus und Konzentration von PA wurden in beiden Gruppen nicht beeinflußt. Bei 4 Patienten der Gruppe I führte Angiotensin II-Blockade zu keiner RR-Senkung. Die Ergebnisse sind mit der Annahme vereinbar, daß die Unterschiede im Renin-Rhythmus und im Blutdruckverhalten nach akuter β-Rezeptorenblockade durch eine unterschiedliche neuroadrenerge Aktivität der beiden Gruppen bedingt sind.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Microsystem technologies 1 (1994), S. 10-13 
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract The high precision accelerometer consists of 5 silicon wafers and packages by silicon fusion bonding. The sensor has a capacitance measuring principle and works in an open loop or closed loop operation mode. The etching process for the realization of thin beams and seismic mass, the silicon fusion bonding and the metallization process are described.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Journal of chemical ecology 20 (1994), S. 1483-1493 
    ISSN: 1573-1561
    Keywords: Carpophilus obsoletus ; sap beetle ; Coleoptera ; Nitidulidae ; aggregation pheromone ; hydrocarbon ; tetraene ; date
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Males ofCarpophilus obsoletus Erichson produce an aggregation pheromone to which both sexes respond. The pheromone was identified by GC-MS as (2E,4E,6E,8E)-3,5,7-trimethyl-2,4,6,8-undecatetraene (1), which is also a minor constituent of the pheromone blends ofC. hemipterus (L.),C. freemani Dobson, andC. lugubris Murray. The pheromone was synergized in wind-tunnel bioassays by propyl acetate, a “host-type” coattractant. In a dose-response study, 50 pg of1, plus propyl acetate, was significantly more attractive than just propyl acetate. Pheromone emission from groups of 65 males, feeding on artificial diet, averaged 2.2 ng/male/day. Emissions from individual males were larger, averaging 72 ng/day and ranging as high as 388 ng/day. Synthetic1 was tested in a date garden in southern California (500 µg/rubber septum), using fermenting whole-wheat bread dough as the coattractant. The pheromone plus dough attracted significantly more beetles than dough alone (means were 4.2 and 0.0 beetles per week per trap). Captured beetles were 54% females. Field trap catches were highest during the months of July and August.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 31 (1994), S. 145-148 
    ISSN: 1434-6079
    Keywords: 32.70.Jz ; 31.30.Gs ; 35.10.Bg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract High accuracy measurements of hyperfine structure due to47Ti and49Ti in the 3d 2 4s 2 a 3 F 2−3d 2 4s4p z 5 D 1 absorption line at σ=18482.772 cm−1 have been performed by use of a Doppler-free experiment, where a beam of titanium atoms is crossed by a CW single mode tunable dye laser. They have allowed for the determination of isotope shifts between46Ti,47Ti,48Ti,49Ti and50Ti. By use of accurate values of mean square nuclear charge radii for the even isotopes, it has been possible to separate mass shifts from field shifts and to determine accurate values for the mean square nuclear charge radii of47Ti and49Ti. The field shift presents a marked odd-even staggering.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Mammalian genome 5 (1994), S. 395-396 
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 56 (1917), S. 441-443 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 19
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The structure of the two most abundant toxaphene congeners has unequivocally been established by 500 MHz1H NMR spectroscopy as 2-endo,3-exo,5-endo, 6-exo,8,8,9,10,10-nonachlorobornane (TOX9) and as 2-endo,3-exo,5-endo,6-exo,8,8,10,10-octachlorobornane (TOX8). Semiempirical calculations (AM1 and PM3-MNDO) were carried out for both structures. The distance information found by nuclear Overhauser enhancement (NOE) for the protons is in agreement with the energy minimized AM1 and PM3-MNDO structures. For these definitively established NMR data for TOX8 and TOX9, together with literature data for other toxaphene isolates, a set of rules has been derived for1H chemical shifts in polychlorinated bornane structures. A set of rules is also proposed for assigning systematical nomenclature to NMR-derived polychloro bornane structures.
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