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  • 1
    Online-Ressource
    Online-Ressource
    American Physiological Society ; 2007
    In:  Journal of Applied Physiology Vol. 103, No. 4 ( 2007-10), p. 1113-1120
    In: Journal of Applied Physiology, American Physiological Society, Vol. 103, No. 4 ( 2007-10), p. 1113-1120
    Kurzfassung: Other than diet and medication, exercise is considered one of the three cornerstones of good diabetes treatment. Nevertheless, current clinical guidelines on Type 2 diabetes provide no detailed information on the modalities of effective exercise intervention in the treatment of Type 2 diabetes. Based on a review of currently available literature, exercise modalities are being identified to maximize the benefits of exercise intervention in the treatment of different Type 2 diabetes subpopulations. Both endurance and resistance types of exercise have equal therapeutic strength to improve metabolic control in patients with Type 2 diabetes. When applying endurance-type exercise, energy expenditure should be equivalent to ∼1.7–2.1 MJ/exercise bout on 3 but preferably 5 days/wk. In sarcopenic or severely deconditioned patients with Type 2 diabetes, focus should lie on the implementation of resistance-type exercise to attenuate and/or reverse the decline in skeletal muscle mass and strength. Before choosing the most appropriate exercise modalities, the patient's disease stage should be well characterized, and an ECG-stress test should be considered. Based on baseline aerobic fitness, level of co-morbidities, body composition, and muscle strength, patients should be provided with an individually tailored exercise intervention program to optimize therapeutic value. A multidisciplinary individualized approach and continued exercise training under personal supervision is essential to enhance compliance and allow long-term health benefits of an exercise intervention program.
    Materialart: Online-Ressource
    ISSN: 8750-7587 , 1522-1601
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: American Physiological Society
    Publikationsdatum: 2007
    ZDB Id: 1404365-8
    SSG: 12
    SSG: 31
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Springer Science and Business Media LLC ; 2009
    In:  Acta Diabetologica Vol. 46, No. 4 ( 2009-12), p. 263-278
    In: Acta Diabetologica, Springer Science and Business Media LLC, Vol. 46, No. 4 ( 2009-12), p. 263-278
    Materialart: Online-Ressource
    ISSN: 0940-5429 , 1432-5233
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2009
    ZDB Id: 1468518-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 302, No. 3 ( 2012-02), p. E365-E373
    Kurzfassung: Lack of physical activity has been related to an increased risk of developing insulin resistance. This study aimed to assess the impact of chronic muscle deconditioning on whole body insulin sensitivity, muscle oxidative capacity, and intramyocellular lipid (IMCL) content in subjects with paraplegia. Nine subjects with paraplegia and nine able-bodied, lean controls were recruited. An oral glucose tolerance test was performed to assess whole body insulin sensitivity. IMCL content was determined both in vivo and in vitro using 1 H-magnetic resonance spectroscopy and fluorescence microscopy, respectively. Muscle biopsy samples were stained for succinate dehydrogenase (SDH) activity to measure muscle fiber oxidative capacity. Subcellular distributions of IMCL and SDH activity were determined by defining subsarcolemmal and intermyofibrillar areas on histological samples. SDH activity was 57 ± 14% lower in muscle fibers derived from subjects with paraplegia when compared with controls ( P 〈 0.05), but IMCL content and whole body insulin sensitivity did not differ between groups. In muscle fibers taken from controls, both SDH activity and IMCL content were higher in the subsarcolemmal region than in the intermyofibrillar area. This typical subcellular SDH and IMCL distribution pattern was lost in muscle fibers collected from subjects with paraplegia and had changed toward a more uniform distribution. In conclusion, the lower metabolic demand in deconditioned muscle of subjects with paraplegia results in a significant decline in muscle fiber oxidative capacity and is accompanied by changes in the subcellular distribution patterns of SDH activity and IMCL. However, loss of muscle activity due to paraplegia is not associated with substantial lipid accumulation in skeletal muscle tissue.
    Materialart: Online-Ressource
    ISSN: 0193-1849 , 1522-1555
    Sprache: Englisch
    Verlag: American Physiological Society
    Publikationsdatum: 2012
    ZDB Id: 1477331-4
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: European Journal of Medical Research, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2016-12)
    Materialart: Online-Ressource
    ISSN: 2047-783X
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2016
    ZDB Id: 2129989-4
    Standort Signatur Einschränkungen Verfügbarkeit
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