In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. Suppl_1 ( 2023-02)
Abstract:
Introduction: White matter hyperintensity (WMH) is a neuroimaging manifestation of cerebrovascular disease that is associated with vascular risk factors and the development of cognitive impairment and stroke. Estimating atherosclerotic cardiovascular disease (ASCVD) risk is a method of measuring the extent of vascular risk for a given individual and, thus, there exists a potential link between ASCVD risk and WMH volume. Methods: We included participants in the SPRINT MIND study who underwent a research MRI with volumetric quantification of the burden of WMH in mL. We report the WMH burden by categories of 10-year ASCVD risk using the Pooled Cohort Equations CV Risk (2014 edition). The ASCVD categories include low (0-5%), borderline (5-7.49%), intermediate (7.5-19.9%), and high ( 〉 20%). We used a violin plot to show the results graphically and also report the medians and IQR. As a secondary outcome we report WMH progression, which is the difference in WMH burden between the baseline MRI and a follow-up MRI performed 48 months later. Results: We included 727 individuals, of which 22 (3.0%) were low, 46 (6.3%) were borderline, 370 (50.9%) were intermediate, and 289 (39.8%) were high ASCVD risk. The median (IQR) WMH burden was 1.6 mL (0.9-2.9) in the low, 1.7 mL (1.1-3.0) in the borderline, 2.7 mL (1.4-5.1) in the intermediate, and 4.7 mL (2.5-10.7) in the high ASCVD risk group (p 〈 0.001) (Figure 1). The progression of WMH was 0.2 mL (-0.1-0.7) in the low, 0.4 mL (-.2-1.5) in the borderline, 0.6 mL (0.01-1.7) in the intermediate, and 1.1 mL (0.2-3.0) in the high ASCVD risk group (p=0.001). Conclusions: There is a positive association between ASCVD risk and WMH volume and progression. ASCVD risk, which can be assessed through demographic and clinical variables, may be a useful predictor of the volume of WMH, which is traditionally obtained through an MRI scan.
Type of Medium:
Online Resource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/str.54.suppl_1.127
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
1467823-8
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