In:
ChemBioChem, Wiley, Vol. 21, No. 20 ( 2020-10-15), p. 2916-2920
Abstract:
Novel chemical biology probes linking a serine hydrolase‐directed fluorophosphonate warhead and cereblon‐binding pomalidomide were assessed for the degradation of serine hydrolases. A quantitative proteomics approach to detect degraded proteins revealed that, despite the engagement of ∼40 serine hydrolases, degradation was achieved for only a single serine hydrolase, lysophospholipase II (LYPLA2).
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.202000253
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2020469-3
SSG:
12
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