In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1171, No. 1 ( 2009-08), p. 606-616
Abstract:
Vacuolar‐H + ‐ATPase plays a critical role in the cellular balance of protons, thus regulating intracellular pH and contributing to apoptosis resistance, drug resistance, and invasive and metastatic behavior of cells. NiK‐12192, a vacuolar‐H + ‐ATPase inhibitor, caused a reduction in the volume and/or acidity of lysosomes, a polarization of αvβ5 integrin distribution, and a number of floating live cells, whereas signs of apoptosis appeared only after 72 h of treatment. In conclusion, NiK‐12192, by affecting vacuolar‐ H + ‐ATPase activity (and intracellular pH), causes a modification of structures crucial for cell adhesion and induces cell death, likely by a modality involving an anoikis‐mediated apoptosis.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2009.1171.issue-1
DOI:
10.1111/j.1749-6632.2009.04705.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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