In:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Wiley, Vol. 19, No. 11 ( 2021-11), p. 1591-1599
Abstract:
Classification of lupus erythematosus (LE) is conflicting as it is carried out from different starting points. Whereas dermatological classifications categorize LE morphologically based on specific cutaneous lesions, rheumatologic classifications are based on symptomatic aspects. Indeed, LE is a systemic autoimmune disease with variable acuity and organ involvement. All cutaneous disease patterns may occur in both limited‐cutaneous and systemic LE. Patients and Methods 76 LE‐patients with complete clinical data, clinical photographs and biopsy of cutaneous manifestations as well as paraclinical findings were retrospectively analyzed. Based on a published two‐dimensional classification system that considers disease‐specific skin manifestations and final disease diagnosis separately, patients’ diagnoses were revised and compared with those in medical records. In addition, the extent to which patients could be clustered by diagnosis based on their LE‐specific skin manifestations, corresponding histopathological changes, and paraclinical data was investigated. Results After re‐evaluation, the proportion of patients with limited‐cutaneous LE decreased from 82% previously to 24%. More than two‐thirds of patients indeed showed intermediate or systemic LE. Disease‐specific skin manifestations, histologic characteristics and paraclinical data did not cluster with final diagnoses. Conclusions First, the work underlines the systemic character of the disease. Second, a two‐dimensional approach can help overcome classification difficulties in LE, as skin‐morphologic and symptomatic aspects can be considered separately.
Type of Medium:
Online Resource
ISSN:
1610-0379
,
1610-0387
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2099463-1
Permalink
