In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-3), p. e0275258-
Abstract:
Cardiac fibrosis is a common cause of most cardiovascular diseases. Leonurine, an alkaloid from Herba leonuri , had been indicated to treat cardiovascular diseases due to its cardioprotective effects. Recently, pyroptosis, a programmed form of cell death that releases inflammatory factors, has been shown to play an important role in cardiovascular diseases, especially cardiac fibrosis. This study examined the novel mechanism by which leonurine protects against cardiac fibrosis. In rats with isoprenaline-induced cardiac fibrosis, leonurine inhibited the expression of proteins related to pyroptosis and improved cardiac fibrosis. In vitro , leonurine inhibited the expression of proteins related to pyroptosis and fibrosis. Additionally, leonurine regulated the TGF-β/Smad2 signalling pathway and inhibited pyroptosis to protect cardiomyocytes and improve cardiac fibrosis. Therefore, leonurine might improve cardiac fibrosis induced by isoprenaline by inhibiting pyroptosis via the TGF-β/Smad2 signalling pathway.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0275258
DOI:
10.1371/journal.pone.0275258.g001
DOI:
10.1371/journal.pone.0275258.g002
DOI:
10.1371/journal.pone.0275258.g003
DOI:
10.1371/journal.pone.0275258.g004
DOI:
10.1371/journal.pone.0275258.g005
DOI:
10.1371/journal.pone.0275258.g006
DOI:
10.1371/journal.pone.0275258.g007
DOI:
10.1371/journal.pone.0275258.g008
DOI:
10.1371/journal.pone.0275258.g009
DOI:
10.1371/journal.pone.0275258.g010
DOI:
10.1371/journal.pone.0275258.s001
DOI:
10.1371/journal.pone.0275258.s002
DOI:
10.1371/journal.pone.0275258.s003
DOI:
10.1371/journal.pone.0275258.s004
DOI:
10.1371/journal.pone.0275258.s005
DOI:
10.1371/journal.pone.0275258.s006
DOI:
10.1371/journal.pone.0275258.s007
DOI:
10.1371/journal.pone.0275258.r001
DOI:
10.1371/journal.pone.0275258.r002
DOI:
10.1371/journal.pone.0275258.r003
DOI:
10.1371/journal.pone.0275258.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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