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  • Hindawi Limited  (5)
  • Zhu, Huijun  (5)
  • 1
    Online Resource
    Online Resource
    Overexpression of Growth-Related Oncogene- β Is Associated with Tumorigenesis, Metastasis, and Poor Prognosis in Ovarian Cancer
    Hindawi Limited ; 2015
    In:  Disease Markers Vol. 2015 ( 2015), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Background . Growth-related oncogene- (GRO-) β is a member of the CXC chemokine family, which may mediate various functions, such as attracting neutrophils to sites of inflammation, regulating angiogenesis, and participating in tumorigenesis and progression. However, the expression of GRO- β in ovarian cancer and its relationship to the clinical characteristics of this disease remain poorly understood. Methods . In this study, immunohistochemical analysis using tissue microarray (TMA) was employed to evaluate the expression of GRO- β in ovarian cancer and to contrast expression with normal ovarian epithelial cells and oviduct epithelial cells. Next, we observed the correlation between GRO- β expression and clinicopathological features of ovarian cancer as well as patient outcome. Results . High GRO- β cytoplasmic expression was observed in 55.15% of patients with ovarian cancer, which was related to lymph node or other metastases ( P 〈 0.001 ), ascites ( P = 0.027 ), and International Federation of Obstetricians and Gynaecologists (FIGO) stage ( P = 0.032 ). Kaplan-Meier survival and Cox regression analysis revealed that high GRO- β expression ( P = 0.002 ) and high CA19-9 level ( P = 0.003 ) were independent prognostic indicators of poor outcome in ovarian cancer. Conclusions . Overall, high GRO- β expression correlates with poor prognosis and contributes to ovarian cancer tumorigenesis and metastasis.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2015/387382
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2033253-1
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  • 2
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    Online Resource
    High Expression of RAR β Is a Favorable Factor in Colorectal Cancer
    Hindawi Limited ; 2019
    In:  Disease Markers Vol. 2019 ( 2019-03-03), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2019 ( 2019-03-03), p. 1-7
    Abstract: RAR β plays a critical role in cancer progression and is associated with several types of human cancer. It remains unclear, however, whether it is linked to the clinicopathological parameters of colorectal cancer (CRC). We therefore determined the expression of RAR β protein in patients with primary CRC and examined its relationship with clinical outcomes. RAR β expression in 234 samples of CRC patients and matched benign noncancerous tumors was detected by immunohistochemistry. RAR β mRNA expression was confirmed using the TCGA and Oncomine databases. COX regression analysis and Kaplan–Meier survival analysis were performed to determine the relationship between RAR β expression and CRC prognosis. Our results show that high expression of RAR β correlated with better prognosis in CRC patients. RAR β expression in CRC specimens was clearly lower than in peritumoral specimens (30.8% vs 58.8%, p 〈 0.001 ) and significantly correlated with gender ( χ 2 = 3.926 , p = 0.048 ), tumor differentiation ( χ 2 = 5.978 , p = 0.014 ), and tumor stage ( χ 2 = 6.642 , p = 0.036 ). Multivariate analyses further revealed that low RAR β expression ( p = 0.001 ), distant metastasis ( p = 0.001 ), tissue differentiation ( p = 0.006 ), and tumor stage ( p = 0.002 ) were associated with overall survival in CRC patients. In addition, Kaplan–Meier analysis indicated that increased RAR β expression in cytoplasm ( p = 0.001 ) and early tumor TNM stage ( p = 0.030 ) was associated with a more favorable outcome in patients with CRC. In conclusion, RAR β expression was strongly correlated with several clinicopathological factors of CRC and may represent a favorable prognostic marker in patients with CRC.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2019/7138754
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2033253-1
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  • 3
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    Online Resource
    Prognostic Value of Rab27B Nuclear Expression in Gastrointestinal Stromal Tumors
    Hindawi Limited ; 2014
    In:  Disease Markers Vol. 2014 ( 2014), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: Rab proteins of the endocytosis and exocytosis pathways both play critical roles in cancer progression, and Rab27B has a significant relationship with several types of human cancer. However, the association between Rab27B expression and clinical features to determine its clinicopathological significance in gastrointestinal tumor (GIST) has not been investigated. To examine the expression of Rab27B in GIST and investigate the association between its expression and patient prognosis, immunohistochemistry analysis with tissue microarray was used to evaluate expression of Rab27B in 162 patients with GIST. The relationship between Rab27B expression and patient prognosis was analyzed. High nuclear staining of Rab27B was detected in 88 of 162 (54.32%) GIST tissues. Positive staining of Rab27B was significantly associated with tumor size ( P = 0.006 ), mitotic index ( P = 0.013 ), Armed Forces Institute of Pathology Miettinen risk classification ( P = 0.002 ), and tumor grade ( P = 0.021 ). Kaplan-Meier survival curves showed that GIST patients with low Rab27B nuclear expression ( P = 0.038 ) and mitotic index 〈 5 per 50 high-power fields ( P = 0.029 ) had a more favorable prognosis. These findings indicate that Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2014/942181
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2033253-1
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  • 4
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    Online Resource
    Association of High Expression of Gro β with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors
    Hindawi Limited ; 2015
    In:  Disease Markers Vol. 2015 ( 2015), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: GRO β (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GRO β expression in gastrointestinal stromal tumors (GIST) or the relationship between GRO β expression and clinical attributes of GIST. GRO β expression was examined via immunohistochemical staining of 173 GIST samples using tissue microarray. The relationship between GRO β expression and relevant patient and tumor characteristics was assessed, using chi-square tests. Univariate and multivariate analysis was carried out using the Cox regression method. High GRO β cytoplasm staining was detected in 56 (32.4%) specimens; high GRO β nuclear staining was detected in 64 (37.0%) specimens. High GRO β cytoplasm staining was significantly associated with patients’ age ( P = 0.043 ) and tumor location ( P = 0.014 ), while high GRO β nucleus staining was significantly associated with mitotic index ( P = 0.034 ), tumor location ( P = 0.049 ), and AFIP-Miettinen risk classification ( P = 0.048 ). Kaplan-Meier survival curves showed GIST patients with low GRO β cytoplasm expression ( P = 0.023 ) and mitotic index 〈 6 per 50 HPFs ( P = 0.026 ) to have a more favorable prognosis. These findings indicate that GRO β expression correlates with malignant GIST phenotypes and could be an unfavorable prognostic marker in patients with GIST.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2015/171035
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
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  • 5
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    Online Resource
    Shionone Relieves Urinary Tract Infections by Removing Bacteria from Bladder Epithelial Cells
    Hindawi Limited ; 2023
    In:  Cellular Microbiology Vol. 2023 ( 2023-2-3), p. 1-9
    Details
    In: Cellular Microbiology, Hindawi Limited, Vol. 2023 ( 2023-2-3), p. 1-9
    Abstract: In clinical practice, urinary tract infections (UTIs) are second only to respiratory infections in terms of infectious diseases. In recent years, drug resistance of Escherichia coli (E. coli) has increased significantly. The therapeutic effects of Shionone on UTI were assessed by modelling UTI in SD rats and SV-HUC-1 cells with E. coli solution. After treatment of Shionone, the UTI rat model showed a decrease in wet weight/body weight of bladder, as well as a reduction in cellular inflammatory infiltration of bladder tissue and a decrease in urinary levels of IL-6, IL-1β, and TNF-α. In addition, the levels of proinflammatory factors were significantly reduced in a dose-dependent manner in UTI cell model treated with different doses of Shionone (5, 10, and 20 μg/kg). The results of immunofluorescence analysis in both in vivo and in vitro experiments revealed that Shionone reduced bacterial load and the number of E. coli colonies growing on the plates was greatly reduced. These results suggested that Shionone has a good therapeutic effect on UTI, achieved by reducing bacterial load in bladder epithelial cells. The data presented here provide a basis for further research into the treatment of UTI.
    Type of Medium: Online Resource
    ISSN: 1462-5822 , 1462-5814
    URL: Article
    DOI: 10.1155/2023/3201540
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2019990-9
    SSG: 12
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