In:
Clinical Endocrinology, Wiley, Vol. 88, No. 5 ( 2018-05), p. 700-705
Abstract:
This study was to explore the link between gamma‐glutamyl transferase ( GGT ), alanine transaminase ( ALT ) and aspartate transaminase ( AST ) levels during early‐middle pregnancy and subsequent risk of gestational diabetes mellitus ( GDM ). Methods In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT , AST and ALT levels were tested during weeks 14‐18 of gestation and oral glucose tolerance test was conducted during 24‐28 weeks to screen GDM . Results The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non‐ GDM women (18.7 ± 13.0 vs 14.5 ± 7.0, P 〈 .001). The higher GGT level was 26.9~74.0 U/L, which was significantly associated with increased risk of GDM . The adjusted RR (95% CI ) comparing higher GGT level versus lower was 5.40 (3.36‐8.68). No significant correlation was found between ALT or AST levels and the risk of GDM . Conclusions The results suggest that pregnant women with higher serum GGT during early‐middle pregnancy have higher risk of developing GDM . A GGT level 〉 26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2018.88.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2004597-9
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