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  • Oxford University Press (OUP)  (5)
  • Zhou, Shenghua  (5)
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  • Oxford University Press (OUP)  (5)
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  • 1
    Online Resource
    Online Resource
    Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study
    Oxford University Press (OUP) ; 2023
    In:  European Heart Journal Open Vol. 3, No. 3 ( 2023-05-02)
    Details
    In: European Heart Journal Open, Oxford University Press (OUP), Vol. 3, No. 3 ( 2023-05-02)
    Abstract: There is still no non-invasive septal reduction therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to investigate the feasibility, safety, and efficacy of stereotactic body radiotherapy (SBRT) in patients with drug-refractory symptomatic HOCM. Methods and results The radiation target of ventricular septum was determined by multiple anatomical imaging. Stereotactic body radiotherapy was performed with standard techniques. Patients were treated with a single fraction of 25 Gy, followed up at 1, 3, 6, and 12 months by clinical visit. Five patients were enrolled and completed the 12 months follow-up. The mean radioablation time was 21.6 min, and the mean target volume was 10.5 cm3. All five patients survived and showed improvements in symptoms after SBRT. At 12 months post-SBRT, the echocardiography-derived left ventricular outflow tract gradient decreased from 88 mmHg (range, 63–105) to 52 mmHg (range, 36–66) at rest and from 101 mmHg (range, 72–121) to 74 mmHg (range, 65–100) after Valsalva. The end-diastolic thickness of the targeted septum reduced from 23.7 mm (range, 20.3–29) to 22.4 mm (range, 19.7–26.5); 6 min walking distance increased from 190.4 m (range, 50–370) to 412.0 m (range, 320–480). All patients presented with new fibrosis in the irradiated septum area. No radiation-related complications were observed during SBRT and up to 12 months post procedure. Conclusion The current study suggests that SBRT might be a feasible radioablation therapeutic option for patients with drug-refractory symptomatic HOCM. Trial registration ClinicalTrials.gov Identifier: NCT04686487
    Type of Medium: Online Resource
    ISSN: 2752-4191
    URL: Article
    DOI: 10.1093/ehjopen/oead052
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 3112907-9
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  • 2
    Online Resource
    Online Resource
    Recurrent myocardial infarction due to coronary artery aneurysm in Behçet’s syndrome: a case report
    Oxford University Press (OUP) ; 2019
    In:  European Heart Journal - Case Reports Vol. 3, No. 4 ( 2019-12-01), p. 1-4
    Details
    In: European Heart Journal - Case Reports, Oxford University Press (OUP), Vol. 3, No. 4 ( 2019-12-01), p. 1-4
    Abstract: Behçet’s syndrome (BS) is a multisystemic vasculitis of unknown aetiology. Coronary involvement is extremely uncommon in BS, with a reported prevalence of 0.5%. The mortality of cardiovascular manifestation in BS is 20%, while there are still considerable challenges in the management of these patients. Case summary We report the case of a 30-year-old young man with a 12-year history of BS complicated by left anterior descending coronary (LAD) aneurysms, stenosis, and recurrent myocardial infarction. Percutaneous coronary intervention treated the stenosis and aneurysms of the LAD, but the coronary angiography clearly revealed an acute stent thrombosis after 7 months. This unusual coronary complication of BS treated successfully is presented. Discussion Our case demonstrated the feasibility of covered stent, immunosuppressive therapy, and escalated antithrombotic regimen in the treatment of BS patients with coronary artery aneurysm (CAA). We also demonstrated that drug-eluting stents may aggravate aneurysmal dilatation of the CAA under inefficient immunosuppressive therapy.
    Type of Medium: Online Resource
    ISSN: 2514-2119
    URL: Article
    DOI: 10.1093/ehjcr/ytz204
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2948381-5
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  • 3
    Online Resource
    Online Resource
    Dietary fruits and vegetables and risk of cardiovascular diseases in elderly Chinese
    Oxford University Press (OUP) ; 2023
    In:  European Journal of Public Health ( 2023-08-01)
    Details
    In: European Journal of Public Health, Oxford University Press (OUP), ( 2023-08-01)
    Abstract: Evidence regarding the potential effect of fruit and vegetable consumption on cardiovascular diseases (CVD) was limited and inconsistent among Asian people. Methods We prospectively examined associations of fruit and vegetable consumption with the risk of CVD among 9740 participants aged 65 years and older (mean baseline age: 88 years) in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) (2008–2018). Dietary data were collected using a validated food frequency questionnaire. Results During 37 366 person-years of follow-up, a total of 3738 CVD cases were recorded. After adjusting for demographics, dietary, lifestyle and economical social factors, higher intakes of total fruits and vegetables were associated with lower risk of CVD [comparing with extreme quintiles, hazard ratio and 95% confidence interval: 0.84 (0.74, 0.95)]. The inverse association was mainly driven by vegetable consumption [0.86 (0.77, 0.95)] . Furthermore, the inverse association was stronger for the risk of hypertension [0.84 (0.72, 0.98)]. These associations were consistent across age, sex, body mass index, residence, exercise status, smoking, drinking, meat intake, modified hPDI and health status. Conclusions This study suggests higher intakes of total fruits and vegetables are associated with a lower risk of CVD among elderly Chinese people, supporting the current recommendations of increasing fruit and vegetable consumption as part of a healthy diet for the prevention of CVD.
    Type of Medium: Online Resource
    ISSN: 1101-1262 , 1464-360X
    URL: Article
    DOI: 10.1093/eurpub/ckad131
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2033525-8
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  • 4
    Online Resource
    Online Resource
    High prevalence of arrhythmic and myocardial complications in patients with cardiac glycogenosis due to PRKAG2 mutations: comment
    Oxford University Press (OUP) ; 2018
    In:  EP Europace Vol. 20, No. 8 ( 2018-08-01), p. 1389-1389
    Details
    In: EP Europace, Oxford University Press (OUP), Vol. 20, No. 8 ( 2018-08-01), p. 1389-1389
    Type of Medium: Online Resource
    ISSN: 1099-5129 , 1532-2092
    URL: Article
    DOI: 10.1093/europace/eux238
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2002579-8
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  • 5
    Online Resource
    Online Resource
    Transient cardiac electrophysiological changes in a rat model of subarachnoid haemorrhage: a brain–heart interaction
    Oxford University Press (OUP) ; 2023
    In:  Europace Vol. 25, No. 6 ( 2023-06-02)
    Details
    In: Europace, Oxford University Press (OUP), Vol. 25, No. 6 ( 2023-06-02)
    Abstract: Subarachnoid haemorrhage (SAH) is one of the causes of sudden cardiac death (SCD). However, the time course of ventricular arrhythmias and potential mechanisms responsible for this effect after SAH remain unknown. Objective This study aims to investigate the effect of SAH on ventricular electrophysiological changes and its potential mechanisms in long-term phase. Methods and results We examined the ventricular electrophysiological remodelling and potential mechanisms in a Sprague Dawley rat model of SAH at six time points (baseline, and Days 1, 3, 7, 14 and 28) and explored the potential mechanisms. We measured the ventricular effective refractory period (ERP), ventricular fibrillation threshold (VFT) and left stellate ganglion (LSG) activity at different time points before and after SAH. We also detected neuropeptide Y (NPY) levels in plasma and myocardial tissues by enzyme-linked immunosorbent assay, and quantified NPY 1 receptor (NPY1R) protein and mRNA expression levels by western blotting and quantitative real-time reverse transcription-polymerase chain reaction, respectively. Subarachnoid haemorrhage gradually prolonged QTc intervals, shortened ventricular ERP and reduced VFT during the acute phase, peaking at Day 3. However, no significant changes were observed from Days 14 to 28 compared to Day 0. Subarachnoid haemorrhage gradually increased LSG activity, increased NPY concentrations and up-regulated NPY1R expression in the acute phase of SAH, peaking at Day 3. However, no significant variations were found from Days 14 to 28 compared to Day 0. Conclusion Subarachnoid haemorrhage increases the transient susceptibility of VAs in the acute phase, and the underlying mechanisms for this response included increased sympathetic activity and up-regulated NPY1R expression.
    Type of Medium: Online Resource
    ISSN: 1099-5129 , 1532-2092
    URL: Article
    DOI: 10.1093/europace/euad171
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2002579-8
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