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  • 1
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    Online Resource
    Effects of dietary Bacillus coagulans and yeast hydrolysate supplementation on growth performance, immune response and intestinal barrier function in weaned piglets
    Wiley ; 2021
    In:  Journal of Animal Physiology and Animal Nutrition Vol. 105, No. 5 ( 2021-09), p. 898-907
    Details
    In: Journal of Animal Physiology and Animal Nutrition, Wiley, Vol. 105, No. 5 ( 2021-09), p. 898-907
    Abstract: The present study investigated the effects of Bacillus coagulans and yeast hydrolysate supplementation on growth performance, immune response and intestinal barrier function of weaned piglets. Twenty‐four weaned piglets with an average body weight (BW) of 6.89 ± 0.15 kg were divided into four diets for 28 days. The treatments were basal diet (control), basal diet supplemented with antibiotic (20 mg/kg colistin sulphate and 40 mg/kg bacitracin zinc, AT), probiotics (400 mg/kg Bacillus coagulans ≥5 × 109 CFU/g, BC) or yeast hydrolysate (5000 mg/kg yeast hydrolysate, YH). Average daily gain (ADG) and average daily feed intake (ADFI) were improved by AT and YH diets ( p   〈  0.05), while BC diet only increased ADG ( p   〈  0.05). The complement 3 (C3), lysozyme (LZM) and tumour necrosis factor‐α (TNF‐α) concentrations in serum were increased in BC diet ( p   〈  0.05). Feeding AT and YH caused the increase of jejunal villus height ( p   〈  0.05), and a higher ratio of villus height/crypt depth was observed in AT, BC and YH groups ( p   〈  0.05). The mRNA expression of zonula occludens ‐ 1 (ZO ‐ 1) in jejunal mucosa was up‐regulated by AT, BC and YH diets ( p   〈  0.05). Dietary AT, BC or YH inclusion decreased the interleukin‐1β (IL‐1β) concentration and TNF ‐ α mRNA expression ( p   〈  0.05), and YH supplementation even down‐regulated toll ‐ like receptor 4 (TLR4) and CD14 expressions ( p   〈  0.05). In summary, the dietary administration of BC or YH both improves growth performance through promoting the intestinal barrier function, indicating both of them can serve as potential alternatives to antibiotics growth promoters for the piglet production.
    Type of Medium: Online Resource
    ISSN: 0931-2439 , 1439-0396
    URL: Issue
    URL: Article
    DOI: 10.1111/jpn.v105.5
    DOI: 10.1111/jpn.13529
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020405-X
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  • 2
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    Online Resource
    Prebiotic inulin as a treatment of obesity related nonalcoholic fatty liver disease through gut microbiota: a critical review
    Informa UK Limited ; 2023
    In:  Critical Reviews in Food Science and Nutrition Vol. 63, No. 7 ( 2023-03-11), p. 862-872
    Details
    In: Critical Reviews in Food Science and Nutrition, Informa UK Limited, Vol. 63, No. 7 ( 2023-03-11), p. 862-872
    Type of Medium: Online Resource
    ISSN: 1040-8398 , 1549-7852
    URL: Article
    DOI: 10.1080/10408398.2021.1955654
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2028517-6
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  • 3
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    Effect of 3-caffeoylquinic acid on growth performance, nutrient digestibility, and intestinal functions in weaned pigs
    Oxford University Press (OUP) ; 2023
    In:  Journal of Animal Science Vol. 101 ( 2023-01-03)
    Details
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 101 ( 2023-01-03)
    Abstract: Phenolic acid like with the 3-caffeoylquini acid (3-CQA) is formed by caffeic acid and qunic acid. This study was conducted to explore the effect of 3-CQA on growth performance and intestinal functions in weaned pigs. A total of 180 weaned pigs were randomly allocated into five treatments with 6 replicate pens per treatment (6 pigs per pen). Pigs in the control group (CON) were fed with basal diet (BD), and the others in the experimental groups were fed with BD and supplemented with 12.5, 25, 50, and 100 mg/kg 3-CQA. On day 43, the blood sample-collected pigs in the CON and optimal-dose group (only based on growth performance) were picked, and housed in metabolism cages (a total of 12 pigs, N = 6). 3-CQA increased the feed efficiency from days 21 to 42 of the trial and throughout the trial (P & lt; 0.05). 3-CQA increased the serum concentrations of total protein, albumin, and total cholesterol (P & lt; 0.05). Moreover, 3-CQA supplementation at 25 mg/kg increased the apparent digestibility of DM, energy, and ash (P & lt; 0.05). Interestingly, 3-CQA decreased the crypt depth but increased the ratio of villus height to crypt depth in the jejunum and ileum (P & lt; 0.05). Moreover, 3-CQA also increased the activities of sucrase, lactase, and catalase in the jejunal mucosa, and increased the activities of alkaline phosphatase and superoxide dismutase in the ileal mucosa (P & lt; 0.05). 3-CQA also increased the abundance of secretory immunoglobulin A in the ileal mucosa (P & lt; 0.05). Importantly, 3-CQA not only elevated the expression levels of critical functional genes such as the zonula occludens-1 , occludin, solute carrier family 7 , and nuclear factor erythroid 2-related factor 2 (Nrf2) in the duodenum but also elevated the expression levels of divalent metal transporter-1 and Nrf2 in the jejunum (P & lt; 0.05). These results suggested a positive effect of 3-CQA supplementation on the growth and intestinal functions of weaned pigs. The mechanisms of action may be associated with elevated anti-oxidant capacity and improved intestinal barrier functions.
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    URL: Article
    DOI: 10.1093/jas/skad234
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1490550-4
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  • 4
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    Synergetic responses of intestinal microbiota and epithelium to dietary inulin supplementation in pigs
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Nutrition Vol. 60, No. 2 ( 2021-03), p. 715-727
    Details
    In: European Journal of Nutrition, Springer Science and Business Media LLC, Vol. 60, No. 2 ( 2021-03), p. 715-727
    Type of Medium: Online Resource
    ISSN: 1436-6207 , 1436-6215
    URL: Article
    DOI: 10.1007/s00394-020-02284-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1463312-7
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  • 5
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    Selenium-Enriched Yeast Alleviates Oxidative Stress-Induced Intestinal Mucosa Disruption in Weaned Pigs
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-03-19), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-03-19), p. 1-11
    Abstract: To explore the effect of selenium-enriched yeast (SeY) on intestinal barrier functions in weaned pigs upon oxidative stress, a 2 × 2 factorial design was utilized and thirty-two pigs were randomly assigned into four groups. Pigs with or without exposure to oxidative stress (diquat challenge) were fed with a basal diet or a SeY-containing diet. The trial lasted for 21 days, and result showed that SeY supplementation attenuated body-weight reduction and significantly decreased the serum concentrations of diamine oxidase (DAO) and D-lactic acid in pigs upon diquat challenge ( P 〈 0.05 ). Diquat challenge decreased the villus height and the ratio of villus height to crypt depth (V/C) in the jejunum and ileum ( P 〈 0.05 ). However, SeY supplementation not only elevated the villus height and the ratio of V/C ( P 〈 0.05 ) but also improved the distribution and abundance of tight-junction protein ZO-1 in the jejunum epithelium. Interestingly, SeY supplementation acutely decreased the total apoptosis rate of intestinal epithelial cells in pigs upon diquat challenge ( P 〈 0.05 ). Moreover, SeY elevated the content of antioxidant molecules such as glutathione peroxidase (GSH-Px) and catalase (CAT) but significantly decreased the content of malondialdehyde (MDA) in the intestinal mucosa ( P 〈 0.05 ). Importantly, SeY elevated the expression levels of critical functional genes such as the nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), sodium/glucose cotransporter 1 (SGLT1), and B-cell lymphoma-2 (BCL-2) in the intestinal mucosa upon diquat challenge ( P 〈 0.05 ). Moreover, the expression of caspase-3 was downregulated by SeY in the duodenum and jejunum mucosa ( P 〈 0.05 ). These results indicated that SeY attenuated oxidative stress-induced intestinal mucosa disruption, which was associated with elevated mucosal antioxidative capacity and improved intestinal barrier functions.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/5490743
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 6
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    Tannic acid prevents post-weaning diarrhea by improving intestinal barrier integrity and function in weaned piglets
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Animal Science and Biotechnology Vol. 11, No. 1 ( 2020-12)
    Details
    In: Journal of Animal Science and Biotechnology, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2020-12)
    Abstract: Tannic acid (TA) is potential to reduce diarrhea in weaning pigs, but knowledge about the influence of TA on intestinal barrier integrity and function is still scarce. This experiment was conducted to investigate the effects of dietary TA supplementation on growth performance, diarrhea rate, intestinal barrier integrity and function of weaned pigs. Methods A total of 108 crossbred (Duroc × Landrace × Yorkshire) piglets, with an initial average body weight of 6.60 ± 0.27 kg, were allotted to 3 groups (6 pigs/pen and 6 replicates/group) in a randomized complete block design according to their gender and body weight. Piglets were fed the basal diet with 0 (control, CON), 0.2% and 1.0% TA, respectively. The trial lasted for 28 d. Results Compared with the CON group, dietary 0.2% and 1.0% TA supplementation didn’t affect ADFI, ADG and F:G ( P   〉  0.05), but reduced diarrhea rate, diarrhea index and diarrhea score of piglets ( P   〈  0.05), reduced diamine oxidase (DAO) activity and D-lactic acid concentration in serum ( P   〈  0.01). The higher occludin expression and localization were observed in the duodenum, jejunum and ileum after supplementation with 0.2% or 1.0% TA ( P   〈  0.05). Adding 0.2% TA to diet significantly decreased crypt depth, increased villus height/crypt depth ratio in the duodenum ( P   〈  0.05), and dietary 1.0% TA tended to decrease crypt depth ( P   〈  0.10) and significantly decreased villus height ( P   〈  0.05) of the ileum. Moreover, lower malondialdehyde content in the ileum was detected in the pigs fed 1.0% TA ( P   〈  0.05). In the duodenum, both 0.2% and 1.0% TA groups had higher occludin ( OCLN ) mRNA and 0.2% TA group had higher zonula occludens-2 ( ZO-2 ) level ( P   〈  0.05). Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum ( P   〈  0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 ( ZO-1 ) mRNA levels in the ileum ( P   〈  0.10). Conclusion In conclusion, dietary supplementation of 0.2% or 1.0% TA could effectively alleviate post-weaning diarrhea without altering growth performance in weaned piglets, which might be achieved by improving intestinal barrier integrity and function.
    Type of Medium: Online Resource
    ISSN: 2049-1891
    URL: Article
    DOI: 10.1186/s40104-020-00496-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2630162-3
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  • 7
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    Agrobacterium sp. ZX09 β-Glucan Attenuates Enterotoxigenic Escherichia coli-Induced Disruption of Intestinal Epithelium in Weaned Pigs
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 18 ( 2022-09-07), p. 10290-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 18 ( 2022-09-07), p. 10290-
    Abstract: To explore the protective effect of dietary β-glucan (BGL) supplementation on intestinal epithelium exposure to enterotoxigenic Escherichia coli (ETEC), thirty-two weaned pigs were assigned to four groups. Pigs were fed with a basal diet or basal diet containing 500 mg/kg BGL, and were orally infused with ETEC or culture medium. Results showed BGL supplementation had no influence on growth performance in weaned pigs. However, BGL supplementation increased the absorption of D-xylose, and significantly decreased the serum concentrations of D-lactate and diamine oxidase (DAO) in the ETEC-challenged pigs (p 〈 0.05). Interestingly, BGL significantly increased the abundance of the zonula occludens-1-(ZO-1) in the jejunal epithelium upon ETEC challenge (p 〈 0.05). BGL supplementation also increased the number of S-phase cells and the number of sIgA-positive cells, but significantly decreased the number of total apoptotic cells in the jejunal epithelium upon ETEC challenge (p 〈 0.05). Moreover, BGL significantly increased the duodenal catalase (CAT) activity and the ileal total superoxide dismutase (T-SOD) activity in the ETEC-challenged pigs (p 〈 0.05). Importantly, BGL significantly decreased the expression levels of critical inflammation related proteins such as the tumor necrosis factor-α (TNF-α), interlukin-6 (IL-6), myeloid differentiation factor 88 (MyD88), and nuclear factor-κB (NF-κB) in the jejunal and ileal mucosa upon ETEC challenge (p 〈 0.05). BGL also elevated the propanoic acid content and the abundance of Lactobacillus and Bacillus in the colon upon ETEC challenge (p 〈 0.05). These results suggested BGL could alleviate the ETEC-induced intestinal epithelium injury, which may be associated with suppressed inflammation and improved intestinal immunity and antioxidant capacity, as well as the improved intestinal macrobiotic.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms231810290
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 8
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    Ellagic Acid Alters Muscle Fiber-Type Composition and Promotes Mitochondrial Biogenesis through the AMPK Signaling Pathway in Healthy Pigs
    American Chemical Society (ACS) ; 2022
    In:  Journal of Agricultural and Food Chemistry Vol. 70, No. 31 ( 2022-08-10), p. 9779-9789
    Details
    In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 70, No. 31 ( 2022-08-10), p. 9779-9789
    Type of Medium: Online Resource
    ISSN: 0021-8561 , 1520-5118
    URL: Article
    DOI: 10.1021/acs.jafc.2c04108
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2022
    detail.hit.zdb_id: 1483109-0
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  • 9
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    Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model
    American Chemical Society (ACS) ; 2022
    In:  Journal of Agricultural and Food Chemistry Vol. 70, No. 24 ( 2022-06-22), p. 7576-7585
    Details
    In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 70, No. 24 ( 2022-06-22), p. 7576-7585
    Type of Medium: Online Resource
    ISSN: 0021-8561 , 1520-5118
    URL: Article
    DOI: 10.1021/acs.jafc.2c02495
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2022
    detail.hit.zdb_id: 1483109-0
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  • 10
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    Expression and Functional Characterization of a Novel Antimicrobial Peptide: Human Beta-Defensin 118
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-11-9), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-11-9), p. 1-10
    Abstract: Purpose. β-Defensin 118 (DEFB118) is a novel host defense peptide (HDP) identified in humans. To evaluate its potentials for future utilization, the DEFB118 gene was expressed in Escherichia coli (E. coli) and the recombinant protein was fully characterized. Methods. The DEFB118 protein was obtained by heterologous expression using E. coli Rosetta (DE3). Antibacterial activity of DEFB118 was determined by using various bacterial strains. IPEC-J cells challenged by E. coli K88 were used to determine its influences on inflammatory responses. Results. The E. coli transformants yielded more than 250 μg/mL DEFB118 protein after 4 h induction by 1.0 mM IPTG. The DEFB118 was estimated by SDS-PAGE to be 30 kDa, and MALDI-TOF analysis verified that it is a human β-defensin 118. Importantly, the DEFB118 showed antimicrobial activities against both Gram-negative bacteria (E. coli K88 and E. coli DH5α) and Gram-positive bacteria (S. aureus and B. subtilis), with a minimum inhibitory concentration (MIC) of 4 μg/mL. Hemolytic assays showed that DEFB118 had no detrimental impact on cell viability. Additionally, DEFB118 was found to elevate the viability of IPEC-J2 cells upon E. coli K88 challenge. Moreover, DEFB118 significantly decreased cell apoptosis in the late apoptosis phase and downregulated the expression of inflammatory cytokines such as IL-1β and TNF-α in IPEC-J2 cell exposure to E. coli K88. Conclusions. These results suggested a novel function of the mammalian defensins, and the antibacterial and anti-inflammatory properties of DEFB118 may allow it as a potential substitute for conventionally used antibiotics or drugs.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2020/1395304
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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