In:
Synlett, Georg Thieme Verlag KG, Vol. 29, No. 06 ( 2018-04), p. 773-778
Abstract:
Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramolecular cyclization, nucleophilic addition of indole, and subsequent N–N bond cleavage. The transformation from readily available starting materials into an interesting class of indole-substituted isoquinolines was completed under mild conditions and by simple operations in moderate to good yields. The antitumor activity of these compounds in vitro was significantly greater than that of a reference compound, 5-fluorouracil. The products might serve as new lead compounds for drugs for the treatment of cancer.
Type of Medium:
Online Resource
ISSN:
0936-5214
,
1437-2096
DOI:
10.1055/s-0036-1591743
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2018
detail.hit.zdb_id:
2042012-2
Permalink