In:
International Journal of Cancer, Wiley, Vol. 145, No. 1 ( 2019-07), p. 179-191
Abstract:
What's new? While ETS transcription factors are known regulators of tumor cell invasion, differentiation and angiogenesis, the function of ETS translocation variant 5 (ETV5) remains unknown. In this study, the authors find ETV5 overexpressed in colorectal carcinoma samples and correlate ETV5 overexpression with poor clinical prognosis. They further connect ETV5 to tumor angiogenesis and identify platelet‐derived growth factor BB as a direct transcriptional target of ETV5. They propose to target this new signaling axis therapeutically in colorectal cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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