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  • 1
    Online Resource
    Online Resource
    Combination of Intracardiac Echocardiography and Contact Force Sensing for Left Ventricular Papillary Muscle Arrhythmias
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 9 ( 2023-04-27), p. 3154-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 9 ( 2023-04-27), p. 3154-
    Abstract: Objectives: The catheter ablation of ventricular arrhythmias (VAs) arising from the left ventricular (LV) papillary muscles (PMs) is challenging. This study sought to address whether the combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) can improve the acute and long-term ablation outcomes of left ventricular papillary muscle arrhythmias. Methods and Results: From May 2015 to August 2022, a total of thirty-three patients underwent catheter ablation for LV PM arrhythmias: VAs were located in anterolateral PMs in 11 and posteromedial PMs in 22. A combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) was used in 21 of the 33 procedures. A mean of 6.93 ± 4.91 for lesions was used per patient, comparable between the CFS/ICE and no ICE/CFS (4.90 ± 2.23 vs. 10.17 ± 5.89; p = 0.011). The mean CF achieved in the ICE/CFS group was 7.52 ± 3.31 g. Less X-ray time was used in the combination group (CFS/ICE: 165.67 ± 47.80 S vs. no ICE/CFS: 365.00 ± 183.73 S; p 〈 0.001). An acute success rate of 100% was achieved for the ICE/CFS group (n = 22) and 66.67% for the no ICE/CFS group (n = 8). VA recurrence at the 11.21 ± 7.21-month follow-up was 14.2% for the ICE/CFS group and 50% for the no ICE/CFS group (p = 0.04). No severe complications occurred in all patients. Conclusions: The combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) could provide precise geometries of cardiac endocavitary structures and accurate contact information for the catheter during ablation, which improved acute and long-term ablation outcomes. The routine adoption of this strategy should be considered to improve the outcomes of LV PM VA ablation.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12093154
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 2
    Online Resource
    Online Resource
    The Influence of Bosentan on MicroRNA-27a/PPARγ/ET-1 Signaling Pathway in Pulmonary Artery Hypertension
    Springer Science and Business Media LLC ; 2021
    In:  Pediatric Cardiology Vol. 42, No. 5 ( 2021-06), p. 1141-1148
    Details
    In: Pediatric Cardiology, Springer Science and Business Media LLC, Vol. 42, No. 5 ( 2021-06), p. 1141-1148
    Type of Medium: Online Resource
    ISSN: 0172-0643 , 1432-1971
    URL: Article
    DOI: 10.1007/s00246-021-02592-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1463000-X
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  • 3
    Online Resource
    Online Resource
    MiR-1/133 attenuates cardiomyocyte apoptosis and electrical remodeling in mice with viral myocarditis
    VM Media Group sp. z o.o ; 2020
    In:  Cardiology Journal Vol. 27, No. 3 ( 2020-06-21), p. 285-294
    Details
    In: Cardiology Journal, VM Media Group sp. z o.o, Vol. 27, No. 3 ( 2020-06-21), p. 285-294
    Type of Medium: Online Resource
    ISSN: 1898-018X , 1897-5593
    URL: Article
    DOI: 10.5603/CJ.a2019.0036
    Language: Unknown
    Publisher: VM Media Group sp. z o.o
    Publication Date: 2020
    detail.hit.zdb_id: 2456710-3
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  • 4
    Online Resource
    Online Resource
    circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS
    Spandidos Publications ; 2021
    In:  International Journal of Molecular Medicine Vol. 48, No. 5 ( 2021-09-16)
    Details
    In: International Journal of Molecular Medicine, Spandidos Publications, Vol. 48, No. 5 ( 2021-09-16)
    Type of Medium: Online Resource
    ISSN: 1107-3756 , 1791-244X
    URL: Journal
    URL: Article
    DOI: 10.3892/ijmm
    DOI: 10.3892/ijmm.2021.5035
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2083937-6
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  • 5
    Online Resource
    Online Resource
    Predictive value of EGSYS score in the differential diagnosis of cardiac syncope and neurally mediated syncope in children
    Frontiers Media SA ; 2023
    In:  Frontiers in Cardiovascular Medicine Vol. 10 ( 2023-3-17)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 10 ( 2023-3-17)
    Abstract: Syncope is a common emergency with diverse etiologies in children. Among these, cardiac syncope (CS) is associated with high mortality and is usually difficult to diagnose. However, there is still no validated clinical prediction model to distinguish CS from other forms of pediatric syncope. The Evaluation of Guidelines in Syncope Study (EGSYS) score was designed to identify CS in adults and has been validated in several studies. In this study, we aimed to assess the ability of the EGSYS score in predicting CS in children. Methods In this retrospective study, we calculated and analyzed the EGSYS scores of 332 children hospitalized for syncope between January 2009 and December 2021. Among them, 281 were diagnosed with neurally mediated syncope (NMS) through the head-up tilt test, and 51 were diagnosed with CS using electrocardiography (ECG), echocardiography (ECHO), coronary computed tomography angiography (CTA), myocardial enzymes and genetic screening. The receiver operating characteristic (ROC) curve and Hosmer-Lemeshow test were used to evaluate the predictive value of the EGSYS score system. Results The median scores of 51 children with CS and 281 children with NMS were 4 [interquartile range (IQR): 3-5] and −1 (IQR: -2-1), respectively. The area under the ROC curve (AUC) was 0.922 [95% confidence interval (CI): 0.892-0.952; P  & lt; 0.001], indicating that the EGSYS score system has good discrimination. The best cutoff point was ≥3, with a sensitivity and specificity of 84.3% and 87.9%, respectively. The Hosmer-Lemeshow test demonstrated satisfactory calibration ( χ ²=1.468, P  & gt; 0.05) of the score, indicating a good fit of the model. Conclusion The EGSYS score appeared to be sensitive for differentiating CS from NMS in children. It might be used as an additional diagnostic tool to aid pediatricians in accurately identifying children with CS in the clinical practice.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    DOI: 10.3389/fcvm.2023.1091778
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2781496-8
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  • 6
    Online Resource
    Online Resource
    Expression of peptide fragments from proADM and involvement of mitogen‐activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow
    Wiley ; 2016
    In:  Congenital Anomalies Vol. 56, No. 1 ( 2016-01), p. 28-34
    Details
    In: Congenital Anomalies, Wiley, Vol. 56, No. 1 ( 2016-01), p. 28-34
    Abstract: Pulmonary arterial hypertension ( PAH ) is a life‐threatening disease characterized by progressive pulmonary arterial remodeling and right ventricular failure. Despite recent advances in pathophysiological mechanism exploration and new therapeutic approaches, PAH remains a challenging condition. In this study, we investigated the roles of the peptide fragments from proadrenomedullin ( proADM ) such as adrenomedullin ( ADM ), adrenotensin ( ADT ), and proadrenomedullin N ‐terminal 20 peptide ( PAMP ) during pulmonary remodeling caused by high pulmonary blood flow, and probed the possible involvement of mitogen‐activated protein kinase ( MAPK ) signal transduction pathways. Sixteen rat models of PAH were artificially established by surgically connecting the left common carotid artery to the external jugular vein. We subcutaneously injected an extracellular signal‐regulated protein kinase ( ERK1 /2) inhibitor, PD 98059, in eight rats, treated another eight rats with an equal volume of saline. Eight rats without connections served as the control group. We observed that mRNA expression levels of ADM , stress‐activated protein kinase ( SAPK ), and ERK1 /2 were significantly elevated in the shunted rats; furthermore, ERK1 /2 levels were significantly inhibited by PD98059. Protein levels of ADM , PAMP , p‐ SAPK , and p‐ ERK1 /2 were significantly higher ADT was lower, and p‐ p38 remained unchanged in the rat models compared with the controls. However, the protein expression of both ADM and p‐ ERK1 /2 was significantly inhibited by PD 98059. Our results suggest that levels of ADM , ADT , and PAMP respond to pulmonary remodeling, and that activation of the SAPK and ERK1 /2 signaling pathways is involved in pulmonary hypertension and artery remodeling caused by high pulmonary blood flow.
    Type of Medium: Online Resource
    ISSN: 0914-3505 , 1741-4520
    URL: Issue
    URL: Article
    DOI: 10.1111/cga.2016.56.issue-1
    DOI: 10.1111/cga.12114
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2139944-X
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  • 7
    Online Resource
    Online Resource
    Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus
    Elsevier BV ; 2017
    In:  Biomedicine & Pharmacotherapy Vol. 94 ( 2017-10), p. 619-626
    Details
    In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 94 ( 2017-10), p. 619-626
    Type of Medium: Online Resource
    ISSN: 0753-3322
    URL: Article
    DOI: 10.1016/j.biopha.2017.07.102
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1501510-5
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  • 8
    Online Resource
    Online Resource
    New pathogenic variant of BMPR2 in pulmonary arterial hypertension
    Cambridge University Press (CUP) ; 2019
    In:  Cardiology in the Young Vol. 29, No. 4 ( 2019-04), p. 462-466
    Details
    In: Cardiology in the Young, Cambridge University Press (CUP), Vol. 29, No. 4 ( 2019-04), p. 462-466
    Abstract: The aim of this study was to evaluate the variant frequency of pulmonary arterial hypertension-related genes and provide theoretical basis for genetic screening of patients with pulmonary arterial hypertension further. Methods: Ten genes associated with pulmonary arterial hypertension were sequenced in 7 cases of idiopathic pulmonary arterial hypertension and 34 cases of congenital heart disease (CHD) associated with pulmonary arterial hypertension by next-generation high-throughput sequencing. Function prediction and gene variant amino acid conservation were carried out by bioinformatics software. Family study was performed on the patients with the variant. Results: A new bone morphogenetic protein receptor type 2( BMPR2 ) variant (c.344T 〉 C, p. F115S) was discovered in a girl who was diagnosed with idiopathic pulmonary arterial hypertension. Her second aunt and third aunt carried the same variant and were confirmed as patients with pulmonary arterial hypertension as well. No variants or single nucleotide polymorphisms were found in other pulmonary arterial hypertension-associated genes. Conclusions: BMPR2 variant is the most common variant of pulmonary arterial hypertension. Genetic screening of BMPR2 variant and family survey in patients with pulmonary arterial hypertension is suggested for the sake of definite cause and better treatment.
    Type of Medium: Online Resource
    ISSN: 1047-9511 , 1467-1107
    URL: Article
    DOI: 10.1017/S1047951119000015
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2060876-7
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  • 9
    Online Resource
    Online Resource
    Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children
    Frontiers Media SA ; 2023
    In:  Frontiers in Pediatrics Vol. 11 ( 2023-8-29)
    Details
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 11 ( 2023-8-29)
    Abstract: Orthostatic intolerance (OI) is usually mediated by the autonomic nerve and most often happens in the upright position. However, it can also occur in other positions and can be relieved by lying down while likely to have another attack after relief. In the current study, we aim to evaluate the predictive effect of catecholamines and electrolytes on the recurrence of OI in children. Materials and methods Children who were diagnosed with vasovagal syncope (VVS), postural tachycardia syndrome (POTS), and VVS combined with POTS were enrolled in this retrospective study and were followed up after 1-year physical treatment. Catecholamines in urine collected within 24 h, renin, angiotensin II, aldosterone in plasma, and electrolytes in both blood and urine collected in the morning were tested. A multivariate analysis and a receiver operating characteristic curve were used to validate the prediction effect. Results In the VVS cohort, the 24 h urine adrenaline (AD) and norepinephrine (NE) levels of the non-recurrence group were lower than the 24 h urine AD and NE levels of the recurrence group, with a significant difference of P   & lt; 0.05. A different content can also be witnessed in the POTS cohort that the urine of the non-recurrence group contained lower sodium and chlorine. As for the VVS + POTS cohort, the non-recurrence group has lower AD and NE levels and higher potassium and phosphorus levels in urine, the difference of which proved prominent as well. Conclusion The study provides further evidence that AD, NE, and electrolytes in urine are promising factors that are closely related to the recurrence of OI in children. The integrated evaluation system merging AD and NE may have better predictive ability.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    URL: Article
    DOI: 10.3389/fped.2023.1220990
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711999-3
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  • 10
    Online Resource
    Online Resource
    Table_1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Public Health Vol. 11 ( 2023-8-4)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 11 ( 2023-8-4)
    Abstract: To assess the disease burden and changing trend of cardiomyopathy in children aged 0–14 years in China from 1990 to 2019. Methods This study was based on the Global Burden of Disease Study 2019; the age-specific prevalence rate, mortality rate and disability-adjusted life year (DALY) rate were used for analysis. Estimated annual percentage change (EAPC) in burden rate and its 95% confidence interval were calculated. The data of China were compared with the global average level. Results In 2019, the numbers of prevalence, deaths, and DALYs of cardiomyopathy in children aged 0–14 years in China were 4,493 [95% uncertainty interval ( UI ): 2687 ~ 6,838], 434 (95% UI : 337 ~ 565) and 37,522 (95% UI : 29,321 ~ 48,891), with declining amplitudes of 16.32, 70.56, and 70.74%, compared with 1990, respectively. In 2019, the prevalence rate of cardiomyopathy in Chinese children aged 0–14 years was 2.00/100,000 (95% UI : 1.2/100,000 ~ 3.04/100,000), higher than 1990 [1.66/100,000 (95% UI :1.00/100,000 ~ 2.53/100,000)]; mortality rate was 0.19/100,000 (95% UI : 0.15/100,000 ~ 0.25/100,000), significantly lower than 1990 [0.46/100,000 (95% UI : 0.25/100,000 ~ 0.95/100,000)]; DALY rate was 16.69/100,000 (95% U I: 13.04/100,000 ~ 21.75/100,000), also significantly lower than 1990 [39.71/100,000 (95% UI : 22.06/100,000 ~ 82.8/100,000)]. All burden rates of cardiomyopathy in Chinese children aged 0–14 years old were all lower than the global averages of 2019; the burden rates of male children were higher than female children. In all calendar years from 1990 to 2019, the mortality and DALY rates of children younger than 1-year-old were significantly higher than in the other age groups of 0–14 years old. From 1990 to 2019, the prevalence rate of cardiomyopathy aged 0–14 years old gradually increased, with EAPC of 0.82 (95% CI : 0.71–0.93); mortality rate and DALY rate decreased [EAPC = −2.32 (95% CI : −2.59 to −2.05)]. Conclusion From 1990 to 2019, the disease burden of cardiomyopathy in children of China aged 0–14 years was heterogeneous; the burden of male children was higher than females; and the burden of cardiomyopathy in children younger than 1 year old needs more attention.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fpubh.2023.1198924
    DOI: 10.3389/fpubh.2023.1198924.s001
    DOI: 10.3389/fpubh.2023.1198924.s002
    DOI: 10.3389/fpubh.2023.1198924.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711781-9
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