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  • 1
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    Online Resource
    Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
    Oxford University Press (OUP) ; 2019
    In:  British Journal of Surgery Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Abstract: The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). Methods This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. Results A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). Conclusion Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11025
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2006309-X
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  • 2
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    The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
    Elsevier BV ; 2018
    In:  British Journal of Anaesthesia Vol. 120, No. 1 ( 2018-01), p. 146-155
    Details
    In: British Journal of Anaesthesia, Elsevier BV, Vol. 120, No. 1 ( 2018-01), p. 146-155
    Type of Medium: Online Resource
    ISSN: 0007-0912
    URL: Article
    DOI: 10.1016/j.bja.2017.08.002
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2011968-9
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  • 3
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    Prediction of postoperative infection in elderly using deep learning-based analysis: an observational cohort study
    Springer Science and Business Media LLC ; 2023
    In:  Aging Clinical and Experimental Research Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Details
    In: Aging Clinical and Experimental Research, Springer Science and Business Media LLC, Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Abstract: Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing with a deep learning model, the perioperative factors that could predict and/or contribute to postoperative infections may improve the outcome in elderly. This was an observational cohort study with 2014 elderly patients who had elective surgery from 28 hospitals in China from April to June 2014. We aimed to develop and validate deep learning-based predictive models for postoperative infections in the elderly. 1510 patients were randomly assigned to be training dataset for establishing deep learning-based models, and 504 patients were used to validate the effectiveness of these models. The conventional model predicted postoperative infections was 0.728 (95% CI 0.688–0.768) with the sensitivity of 66.2% (95% CI 58.2–73.6) and specificity of 66.8% (95% CI 64.6–68.9). The deep learning model including risk factors relevant to baseline clinical characteristics predicted postoperative infections was 0.641 (95% CI 0.545–0.737), and sensitivity and specificity were 34.2% (95% CI 19.6–51.4) and 88.8% (95% CI 85.6–91.6), respectively. Including risk factors relevant to baseline variables and surgery, the deep learning model predicted postoperative infections was 0.763 (95% CI 0.681–0.844) with the sensitivity of 63.2% (95% CI 46–78.2) and specificity of 80.5% (95% CI 76.6–84). Our feasibility study indicated that a deep learning model including risk factors for the prediction of postoperative infections can be achieved in elderly. Further study is needed to assess whether this model can be used to guide clinical practice to improve surgical outcomes in elderly.
    Type of Medium: Online Resource
    ISSN: 1720-8319
    URL: Article
    DOI: 10.1007/s40520-022-02325-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2119282-0
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  • 4
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    Diffusion Bonding of 1420 Al–Li Alloy Assisted by Pure Aluminum Foil as Interlayer
    MDPI AG ; 2020
    In:  Materials Vol. 13, No. 5 ( 2020-03-02), p. 1103-
    Details
    In: Materials, MDPI AG, Vol. 13, No. 5 ( 2020-03-02), p. 1103-
    Abstract: The Al–Li alloy is becoming popular for aerospace application owing to their low density, high specific strength, good corrosion resistance, etc. The diffusion bonding/superplastic forming (DB/SPF) structure of titanium alloy has been widely used in the aerospace industry. In order to broaden the application of Al–Li alloy, it is necessary to develop its diffusion bonding and superplastic forming (DB/SPF) technology. In the present study, diffusion bonding of 1420 Al–Li alloy assisted by pure aluminum foil was conducted on Gleeble-3500 thermal simulation system under different bonding parameters, the results show that the bonding temperatures have direct influence on the interface microstructure and bond strength of joints. Meanwhile, when the pure aluminum interlayer was introduced into the diffusion bonding process, the alloying element diffusion across the bond can improve the interface integrity and the mechanical properties. The joint formation mechanism with interlayer was investigated in detail, the development and application of this method was explored.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma13051103
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2487261-1
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  • 5
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    Fabrication of lattice truss structures by novel super-plastic forming and diffusion bonding process in a titanium alloy
    Elsevier BV ; 2016
    In:  Materials & Design Vol. 92 ( 2016-02), p. 724-730
    Details
    In: Materials & Design, Elsevier BV, Vol. 92 ( 2016-02), p. 724-730
    Type of Medium: Online Resource
    ISSN: 0264-1275
    URL: Article
    DOI: 10.1016/j.matdes.2015.12.100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2015480-X
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  • 6
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    Effect of acceptance and commitment therapy for depressive disorders: a meta-analysis
    Springer Science and Business Media LLC ; 2023
    In:  Annals of General Psychiatry Vol. 22, No. 1 ( 2023-09-07)
    Details
    In: Annals of General Psychiatry, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2023-09-07)
    Abstract: To systematically evaluate the effect of Acceptance and Commitment Therapy (ACT) on depressive disorders. Methods The electronic databases of Web of Science Core Collection, Pubmed, EMBASE, Cochrane Library, PsycInfo, CNKI, Wanfang and Weipu were used to select relevant publications . Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews and meta-analysis. RevMan5.4 was used for meta-analysis. Results 11 studies with a total of 962 patients were included. Random-effects model analysis showed that ACT could effectively reduce the level of depressive symptoms in patients with depressive disorders (SMD = − 1.05, 95% CI: − 1.43–− 0.66, P  〈  0.00001), improve psychological flexibility (MD = 4.84, 95% CI: 2.70–6.97, P  〈  0.00001), and have good maintenance effect (SMD = − 0.70, 95% CI: − 1.15–− 0.25, P = 0.002). All differences were statistically significant. Conclusions ACT not only improves depressive symptoms and psychological flexibility, but also has a good maintenance effect, and it is particularly effective in Chinese patients. Large randomized controlled trials are needed to validate the findings from this meta-analysis.
    Type of Medium: Online Resource
    ISSN: 1744-859X
    URL: Article
    DOI: 10.1186/s12991-023-00462-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2090401-0
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  • 7
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    Effect of superfine grinding on the physico‐chemical and antioxidant properties of Cistanche deserticola powders
    Wiley ; 2023
    In:  Journal of Food Process Engineering Vol. 46, No. 5 ( 2023-05)
    Details
    In: Journal of Food Process Engineering, Wiley, Vol. 46, No. 5 ( 2023-05)
    Abstract: Cistanche deserticola has recently been included in the category of food. In this study, the physical and chemical attributes and antioxidant capacity of six kinds of C. deserticola powders prepared by jet milling were discussed. With the decrease of particle size, the specific surface areas of C. deserticol powders had increased significantly (from 0.040 ± 0.0060 to 0.86 ± 0.030 m 2 ·g −1 ). The repose angles and slide angles (from 18.43 ± 1.15° to 34.21 ± 1.72° and 27.38 ± 1.72° to 35.80 ± 1.49°, respectively), water and oil holding capacities (from 2.40 ± 0.11 to 1.23 ± 0.12 g/g, 0.73 ± 0.12 to 1.39 ± 0.11 g/g, respectively) of superfine C. deserticola powders were compared with coarse powders. Superfine grinding promoted the dissolution of active substances, such as the dissolution of phenylethanol glycoside increased from 0.15% to 2.11%. The ultrafine powders of C. deserticola show great potential in food industry, such as health foods and dietary foods, extending the application of C. deserticola . Practical Applications Cistanche deserticola have recently been included into food catalogue and the ultrafine particles of C. deserticola would be widely used in food industry. Therefore, to understand the physico‐chemical and antioxidant properties are very necessary, which could be conducive to improve their application. The study showed that the ultrafine powders of C. deserticola have better physico‐chemical and antioxidant properties than coarse powders.
    Type of Medium: Online Resource
    ISSN: 0145-8876 , 1745-4530
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpe.v46.5
    DOI: 10.1111/jfpe.14319
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2175259-X
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  • 8
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    Research on residual stress in SiC f reinforced titanium matrix composites
    Techno-Press ; 2014
    In:  Steel and Composite Structures Vol. 17, No. 2 ( 2014-08-25), p. 173-184
    Details
    In: Steel and Composite Structures, Techno-Press, Vol. 17, No. 2 ( 2014-08-25), p. 173-184
    Type of Medium: Online Resource
    ISSN: 1229-9367
    URL: Article
    DOI: 10.12989/scs.2014.17.2.173
    Language: English
    Publisher: Techno-Press
    Publication Date: 2014
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  • 9
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    Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Anesthesiology Vol. 123, No. 2 ( 2015-08-01), p. 409-422
    Details
    In: Anesthesiology, Ovid Technologies (Wolters Kluwer Health), Vol. 123, No. 2 ( 2015-08-01), p. 409-422
    Abstract: Sepsis is characterized by an inappropriate systemic inflammatory response and bacteremia that promote multiorgan failure and mortality. Sphingosine 1-phosphate receptor 2 (S1PR2) modulates endotoxin-induced inflammation in endothelium. However, as a highly expressed S1P receptor in macrophages, its role in regulating macrophage response to bacterial infection remains unclear. Methods: Cecal ligation and puncture or intratracheal instillation of Escherichia coli was induced in wild-type or S1pr2-deficient mice. The antibacterial ability of cell-specific S1PR2 was tested in bone marrow reconstitution mice or mice with macrophage-specific deletion. Signaling molecules responsible for S1PR2-mediated phagocytosis were also measured in the bone marrow–derived macrophages. In addition, S1PR2 expression levels and its correlation with severity of sepsis were determined in critically ill patients (n = 25). Results: Both genetic deletion and pharmaceutical inhibition of S1PR2 significantly limited bacterial burden, reduced lung damage, and improved survival (genetic deletion, 0% in S1pr2+/+vs. 78.6% in S1pr2−/−, P & lt; 0.001; pharmaceutical inhibition, 9.1% in vehicle vs. 22.2% in S1PR2 antagonist, P & lt; 0.05). This protection was attributed to the enhanced phagocytic function of S1PR2-deficient macrophages (mean fluorescent intensity, 2035.2 ± 202.1 vs. 407.8 ± 71.6, P & lt; 0.001). Absence of S1PR2 in macrophage inhibits RhoA-dependent cell contraction and promotes IQGAP1-Rac1-dependent lamellipodial protrusion, whose signaling pathways depend on extracellular stimulators. In septic patients, increased S1PR2 levels in peripheral blood mononuclear cells were positively correlated with the severity of sepsis (r = 0.845, P & lt; 0.001). Conclusions: This study implies that S1PR2, as a critical receptor in macrophage, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis. Interventions targeting S1PR2 signaling may serve as promising therapeutic approaches for sepsis.
    Type of Medium: Online Resource
    ISSN: 0003-3022
    URL: Article
    DOI: 10.1097/ALN.0000000000000725
    RVK:
    XA 22600
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 2016092-6
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  • 10
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    A CRISPR-based nucleic acid detection platform (CRISPR-CPA): Application for detection of Nocardia farcinica
    Oxford University Press (OUP) ; 2022
    In:  Journal of Applied Microbiology Vol. 132, No. 5 ( 2022-05-01), p. 3685-3693
    Details
    In: Journal of Applied Microbiology, Oxford University Press (OUP), Vol. 132, No. 5 ( 2022-05-01), p. 3685-3693
    Abstract: To establish a CRISPR-based nucleic acid detection platform and apply it to the detection of Nocardia farcinica. Methods and Results A CRISPR-based nucleic acid detection platform, termed CRISPR-CPA (CRISPR/Cas12a combined with PCR amplification), which employed PCR for pre-amplification of target sequences and CRISPR-Cas12a-based detection for decoding of the PCR amplicons, was developed. To demonstrate its feasibility, CRISPR-CPA was applied to the detection of N. farcinica. A pair of PCR primers and a crRNA, which targeting the conservative and specific part of gyrA of N. farcinica reference strain IFM 10152, were designed according to the principle of CRISPR-CPA. The whole detection process of N. farcinica CRISPR-CPA assay, including sample pre-treatment and DNA extraction (~20 min), PCR pre-amplification (60 min), CRISPR-based detection (10 min), can be completed within 90 min. A total of 62 isolates were used to evaluate the specificity of N. farcinica CRISPR-CPA assay. Clinical specimens were employed to determine the feasibility of the method in practical application. The limit of detection of the N. farcinica CRISPR-CPA assay is 1 pg DNA per reaction in pure cultures and 105 CFU/ml in sputum specimens, which is similar with culture but significantly more timesaving. Conclusions The N. farcinica CRISPR-CPA assay is an economic and specific method to detect N. farcinica and provides a high-efficiency tool for screening of pathogens especially of some hard-to-culture and slow-growth infectious agents. Significance and Impact of the Study In CRISPR-CPA system, the PCR primers are engineered with a protospacer adjacent motif (PAM) site of Cas12a effector and an additional base A was added at the 5′ end of the engineered PCR primer for protecting PAM site, thus the CRISPR-CPA can detect any sequence. Also, we applied CRISPR-CPA to rapidly detect N. farcinica, which is slow-growing bacteria and is firstly detected by a CRISPR-based method.
    Type of Medium: Online Resource
    ISSN: 1365-2672 , 1364-5072
    URL: Article
    DOI: 10.1111/jam.15424
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2020421-8
    SSG: 12
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