In:
Journal of Heterocyclic Chemistry, Wiley, Vol. 57, No. 3 ( 2020-03), p. 1165-1172
Abstract:
Novel indole amide derivatives C1‐C10 were successfully synthesized and characterized by 1 H NMR, 13 C NMR, IR, MS, and elemental analysis, and their molecular formulas were C 14 H 10 N 6 O, C 13 H 10 N 4 O, C 16 H 13 N 3 O 2 , C 19 H 14 N 2 O 2 , C 16 H 11 N 3 OS, C 15 H 13 N 3 O, C 12 H 9 N 5 O, C 16 H 10 ClN 3 OS, C 15 H 17 N 3 O 2 , and C 13 H 14 N 2 O 3 , respectively. The primary biological activities of these compounds were evaluated in vitro by the DPPH assay, H 2 O 2 ‐induced oxidative stress injury assay, and cytotoxicity assay. The results indicated that compounds C1, C2, C4, C7, and C9 exhibited DPPH·scavenging ability, while C3, C4, C5, and C8 showed potent growth‐inhibitory activities against various human tumor cells, including MDA‐MB‐231, Hela, A549, and HT29. Interestingly, compound C4 showed potent scavenging effects on the DPPH radical and possessed protective effect on H 2 O 2 ‐induced oxidative stress injury in human neuroblastoma SH‐SY5Y cells at low concentrations; however, C4 exhibited significant toxicity against four human tumor cells at a higher concentration in all treatments, and the range of IC 50 value was 7.91 to 13.35 μM.
Type of Medium:
Online Resource
ISSN:
0022-152X
,
1943-5193
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2042274-X
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