In:
Organic & Biomolecular Chemistry, Royal Society of Chemistry (RSC), Vol. 20, No. 6 ( 2022), p. 1284-1291
Abstract:
Spihyperglucinols A (1) and B (2), the first 13,15- nor -polycyclic polyprenylated acylphloroglucinols (PPAPs) featuring a 7/6/5 tricyclic ring system based on an unexpected bicyclo[3.2.2]nonane core, along with three new congeners, spihyperglucinols C–E (3–5), were isolated from Hypericum longistylum . Importantly, 1 and 2 displayed potential inhibitory effects on the production of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with IC 50 values of (8.70 ± 1.18) and (9.23 ± 1.26) μM, respectively, comparable to the positive control, dexamethasone, with an IC 50 value of (9.76 ± 1.13) μM.
Type of Medium:
Online Resource
ISSN:
1477-0520
,
1477-0539
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
2097583-1
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