In:
Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, Vol. 131, No. 04 ( 2023-04), p. 198-204
Abstract:
Background To examine whether the different patterns of post-load insulin
secretion can identify the heterogeneity of type 2 diabetes mellitus (T2DM). Methods Six hundred twenty-five inpatients with T2DM at Jining No. 1
People’s Hospital were recruited from January 2019 to October 2021. The 140 g steamed bread meal test (SBMT) was conducted on patients with
T2DM, and glucose, insulin, and C-peptide levels were recorded at 0, 60, 120, and 180 min. To avoid the effect of exogenous insulin, patients were
categorized into three different classes by latent class trajectory analysis based on the post-load secretion patterns of C-peptide. The difference in short-
and long-term glycemic status and prevalence of complications distributed among the three classes were compared by multiple linear regression and multiple
logistic regression, respectively. Results There were significant differences in long-term glycemic status
(e. g., HbA1c) and short-term glycemic status (e. g., mean blood glucose, time in range) among the three classes. The difference in short-term
glycemic status was similar in terms of the whole day, daytime, and nighttime. The prevalence of severe diabetic retinopathy and atherosclerosis showed a
decreasing trend among the three classes. Conclusions The post-load insulin secretion patterns could well identify
the heterogeneity of patients with T2DM in short- and long-term glycemic status and prevalence of complications, providing recommendations for the timely
adjustment in treatment regimes of patients with T2DM and promotion of personalized treatment.
Type of Medium:
Online Resource
ISSN:
0947-7349
,
1439-3646
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
2037702-2
detail.hit.zdb_id:
1225416-2
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