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  • Wiley  (26)
  • Zhang, Yan  (26)
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  • 1
    Online Resource
    Online Resource
    The neutrophil‐to‐lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90‐day mortality in non‐cirrhotic chronic severe hepatitis
    Wiley ; 2022
    In:  Journal of Digestive Diseases Vol. 23, No. 10 ( 2022-10), p. 587-596
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 23, No. 10 ( 2022-10), p. 587-596
    Abstract: To investigate the relationship between systemic inflammatory response and short‐term mortality in patients with non‐cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil‐to‐lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet‐to lymphocyte ratio (PLR), and monocyte‐to‐lymphocyte ratio (MLR). Methods Data were collected from two prospectively enrolled CATCH‐LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90‐day liver transplant (LT)‐free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90‐day LT‐free mortality. Kaplan–Meier method was used to estimate the 90‐year LT‐free survival. Results The prevalence of CSH was 20.5% (226/1103). The 28‐day and 90‐day LT‐free mortality rates were 17.7% and 26.1%, respectively, for patients with non‐cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90‐day LT‐free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection. Conclusions NLR may be an independent risk factor for 90‐day LT‐free mortality in patients with non‐cirrhotic chronic liver disease. A NLR of 2.9 as the cut‐off value can be used to predict disease aggravation in CSH patients without infection.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v23.10
    DOI: 10.1111/1751-2980.13143
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2317117-0
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  • 2
    Online Resource
    Online Resource
    Expression patterns of tight junction proteins in porcine major salivary glands: a comparison study with human and murine glands
    Wiley ; 2018
    In:  Journal of Anatomy Vol. 233, No. 2 ( 2018-08), p. 167-176
    Details
    In: Journal of Anatomy, Wiley, Vol. 233, No. 2 ( 2018-08), p. 167-176
    Abstract: Tight junction ( TJ ) proteins play a dynamic role in paracellular fluid transport in salivary gland epithelia. Most TJ studies are carried out in mice and rats. However, the morphology of rodent salivary glands differs from that of human glands. This study aimed to compare the histological features and the expression pattern of TJ proteins in porcine salivary glands with those of human and mouse. The results showed that porcine parotid glands were pure serous glands. Submandibular glands ( SMG s) were serous acinar cell‐predominated mixed glands, whereas sublingual glands were mucous acinar cell‐predominated. Human SMG s were mixed glands containing fewer mucous cells than porcine SMG s, whereas the acinar cells of murine SMG s are seromucous. The histological features of the duct system in the porcine and human SMG s were similar and included intercalated, striated and excretory ducts, but the murine SMG contained a specific structure, the granular convoluted tubule. TJ proteins, including claudin‐1 to claudin‐12, occludin and zonula occludin‐1 ( ZO ‐1), were detected in the porcine major salivary glands and human SMG s by RT ‐ PCR ; however, claudin‐6, claudin‐9 and claudin‐11 were not detected in the murine SMG . As shown by immunofluorescence, claudin‐1, claudin‐3, claudin‐4, occludin and ZO ‐1 were distributed in both acinar and ductal cells in the porcine and human SMG s, whereas claudin‐1 and claudin‐3 were mainly present in acinar cells, and claudin‐4 was mainly distributed in ductal cells in the murine SMG . In addition, 3D images showed that the TJ proteins arranged in a honeycomb‐like structure on the luminal surface of the ducts, whereas their arrangements in acini were irregular in porcine SMG s. In summary, the expression pattern of TJ proteins in salivary glands is similar between human and miniature pig, which may be a candidate animal for studies on salivary gland TJ function.
    Type of Medium: Online Resource
    ISSN: 0021-8782 , 1469-7580
    URL: Issue
    URL: Article
    DOI: 10.1111/joa.2018.233.issue-2
    DOI: 10.1111/joa.12833
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2955-5
    detail.hit.zdb_id: 1474856-3
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Parasympathectomy increases resting secretion of the submandibular gland in minipigs in the long term
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 6 ( 2019-06), p. 9515-9524
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 6 ( 2019-06), p. 9515-9524
    Abstract: Parasympathectomy leads to retrogressive alteration and dysfunction of the submandibular gland (SMG) within 1 month, but its long‐term effect is unclear. Excessive secretion is observed in half of the patients 4–6 months after SMG transplantation, which completely denervates the gland. Here, we investigated the long‐term effect of parasympathectomy on the secretion of SMGs in minipigs. The results showed that the resting salivary secretion of SMGs decreased by 82.9% of that in control at 2 months after denervation, but increased by 156% at 6 months. Although experiencing an atrophic period, the denervated glands regained their normal morphology by 6 months. The expression of the function‐related proteins, including muscarinic acetylcholine receptor (mAChR) 3, aquaporin 5 (AQP5), tight junction protein claudin‐3, and claudin‐4 was decreased at 2 months after denervation. Meanwhile, the protein expression of stem cell markers, including sex‐determining region Y‐box 2 and octamer‐binding transcription factor 4, and the number of Ki67 + cells were significantly increased. However, at 6 months after denervation, the expression of mAChR3, AQP5, claudin‐1, claudin‐3, and claudin‐4 was significantly raised, and the membrane distribution of these proteins was increased accordingly. The autonomic axonal area of the glands was reduced at 2 months after denervation but returned to the control level at 6 months, suggesting that reinnervation took place in the long term. In summary, parasympathectomy increases resting secretion of the SMGs in the long term with a possible mechanism involving improved transepithelial fluid transport. This finding may provide a new strategy for xerostomia treatment.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.6
    DOI: 10.1002/jcp.27640
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478143-8
    detail.hit.zdb_id: 3116-1
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Effect of Capsular Closure on Outcomes of Hip Arthroscopy for Femoracetabular Impingement: A Systematic Review and Meta‐analysis
    Wiley ; 2020
    In:  Orthopaedic Surgery Vol. 12, No. 4 ( 2020-08), p. 1153-1163
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 12, No. 4 ( 2020-08), p. 1153-1163
    Abstract: To evaluate the effect of hip arthroscopy with or without capsular closure in femoracetabular impingement (FAI) by meta‐analysis. Methods Pertinent studies were identified by searching Pubmed, EMBASE databases with the last search update on 16 February 2020. Studies that reported hip arthroscopy for FAI were collected. Meta‐analysis was performed by the use of Review Manager 5.3 software. The odds ratios (OR) and mean differences (MD) were used to compare dichotomous and continuous variables. Additionally, the I 2 was used to assess heterogeneity among studies, and the fixed‐effects model or the random‐effects model was selected for the quantitative analysis. Outcomes were evaluated by forest plots. For statistical analysis, P   〈  0.05 was considered significant. Results There was no significant difference among the preoperative mHHS (MD = –2.66，95% CI [−7.25, 1.92], I 2 = 80%, P = 0.25), preoperative (MD = ‐4.94, 95% CI [−11.56, 1.67], I 2 = 50%, P = 0.14) and postoperative HOS‐SSS (MD = ‐1.00, 95% CI [−6.98, 4.98], I 2 = 66%, P = 0.74), patient satisfaction (MD = 0.03, 95% CI [−0.25, 0.31], I 2 = 19%, P = 0.84; OR = 0.94, 95% CI [0.59, 1.50], I 2 = 0%, P = 0.78), complications (OR = 1.23, 95%CI [0.56, 2.67], I 2 = 0%, P = 0.61), revisions (OR = 1.77, 95% CI [0.87, 3.60], I 2 = 36%, P = 0.11), and surgery time (SMD = –0.38, 95% CI [−1.16, 0.40], I 2 = 92%, P = 0.34) between the capsule closure group and the non‐closure group. For the comparison of postoperative mHHS (MD = –2.66, 95% CI [−7.25, 1.92], I 2 = 80%, P = 0.25) and HOS‐ADL (MD = ‐4.20, 95% CI [−5.75, −2.65], I 2 = 24%, P   〈  0.00001), the score of the non‐closure group was significantly better than that of the closure group. Conclusions Remain capsule unclosed after hip arthroscopy for FAI may, to some extent, has a better postoperative functional score than the non‐closure treatment.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v12.4
    DOI: 10.1111/os.12717
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2483883-4
    detail.hit.zdb_id: 2503162-4
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  • 5
    Online Resource
    Online Resource
    A classic screening marker does not affect antennal electrophysiology but strongly regulates reproductive behaviours in Bactrocera dorsalis
    Wiley ; 2024
    In:  Insect Molecular Biology Vol. 33, No. 2 ( 2024-04), p. 136-146
    Details
    In: Insect Molecular Biology, Wiley, Vol. 33, No. 2 ( 2024-04), p. 136-146
    Abstract: The key phenotype white eye (white) has been used for decades to selectively remove females before release in sterile insect technique programs and as an effective screening marker in genetic engineering. Bactrocera dorsalis is a representative tephritid pest causing damage to more than 150 fruit crops. Yet, the function of white in important biological processes remains unclear in B. dorsalis . In this study, the impacts of the white gene on electrophysiology and reproductive behaviour in B. dorsalis were tested. The results indicated that knocking out Bdwhite disrupted eye pigmentation in adults, consistent with previous reports. Bdwhite did not affect the antennal electrophysiology response to 63 chemical components with various structures. However, reproductive behaviours in both males and females were significantly reduced in Bdwhite −/− . Both pre‐copulatory and copulation behaviours were significantly reduced in Bdwhite −/− , and the effect was male‐specific. Mutant females significantly delayed their oviposition towards γ‐octalactone, and the peak of oviposition behaviour towards orange juice was lost. These results show that Bdwhite might not be an ideal screening marker in functional gene research aiming to identify molecular targets for behaviour‐modifying chemicals. Instead, owing to its strong effect on B. dorsalis sexual behaviours, the downstream genes regulated by Bdwhite or the genes from white‐linked areas could be alternate molecular targets that promote the development of better behavioural modifying chemical‐based pest management techniques.
    Type of Medium: Online Resource
    ISSN: 0962-1075 , 1365-2583
    URL: Issue
    URL: Article
    DOI: 10.1111/imb.v33.2
    DOI: 10.1111/imb.12883
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 33602-6
    detail.hit.zdb_id: 2020348-2
    SSG: 12
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  • 6
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    Online Resource
    Noncontrast‐enhanced time‐resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study
    Wiley ; 2018
    In:  Journal of Magnetic Resonance Imaging Vol. 48, No. 1 ( 2018-07), p. 111-120
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 48, No. 1 ( 2018-07), p. 111-120
    Abstract: Arterial spin labeling (ASL) based‐noncontrast‐enhanced 4D MR angiography (NCE 4D MRA) shows potential in characterizing cerebrovascular hemodynamics in cerebrovascular disorders. Ultrahigh‐field theoretically benefits ASL signal with increased inherent signal‐to‐noise ratio (SNR) and prolonged blood T 1 , which may provide improved delineation of vasculature in 4D MRA. Purpose To investigate the feasibility of NCE 4D MRA using 3D Cartesian trajectory and stack‐of‐stars (SOS) golden angle radial trajectory at 7T. Study Type A prospective study. Subjects Six normal volunteers and eight patients with arteriovenous malformation (AVM). Field Strength/Sequence NCE 4D MRA with Cartesian and radial trajectories were performed at 3T and 7T. Assessment Subjective image quality of 4D MRA was evaluated using a 4‐point scale by two experienced neuroradiologists. The characterization of AVM components with 4D MRA and DSA was also graded using the Spetzler–Martin grading scale. Statistical Tests Cohen's kappa coefficient was calculated to evaluate the agreement between two readers within each 4D MRA technique (Cartesian and Radial). A Wilcoxon signed‐rank test was performed to compare the subjective image quality scores of 4D MRA between Cartesian and radial trajectories, and between 7T and 3T, respectively. Results Good‐to‐excellent image quality was achieved in 4D MRA with both Cartesian (3.83 ± 0.41) and radial (3.42 ± 0.49) acquisitions in healthy volunteers at 7T. However, markedly reduced scan time was needed with radial acquisition. 4D MRA at 7T (3.31 ± 0.59) shows better delineation of AVM lesion features, especially the vein drainage, compared with that of 3T (2.83 ± 0.75), although no statistical significance was achieved ( P = 0.180). Data Conclusion The feasibility of ASL based 4D MRA at 7T with Cartesian and SOS golden angle radial acquisition was demonstrated. The clinical evaluation of 4D MRA in AVMs between 3T and 7T suggested 7T 4D MRA images acquired with radial acquisition demonstrate excellent delineation of AVM features, especially the draining veins. Level of Evidence : 2 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2017.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v48.1
    DOI: 10.1002/jmri.25923
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1146614-5
    detail.hit.zdb_id: 1497154-9
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  • 7
    Online Resource
    Online Resource
    Profiles of Streptococcus thermophilus MN ‐ ZLW ‐002 nutrient requirements in controlled pH batch fermentations
    Wiley ; 2019
    In:  MicrobiologyOpen Vol. 8, No. 2 ( 2019-02)
    Details
    In: MicrobiologyOpen, Wiley, Vol. 8, No. 2 ( 2019-02)
    Abstract: This study aimed to evaluate the profiles of Streptococcus thermophilus nutrient requirements to guide the design of media for high cell density culturing. The growth kinetics, physiological state, and nutrient requirement profiles of S. thermophilus were analyzed in chemically defined media. The results showed that the intracellular ATP concentration, H + ‐ ATP ase activity, NADH / NAD + , and NH 3 concentrations varied with intracellular pH . The nutrient components with the highest amounts required were Leu and Asp; ascorbic acid and p ‐amino benzoic acid; K + and PO 4 3− ; and guanine and uracil. The nutrient components with the largest required ratios were Arg, His, and Met; folic acid, cyanocobalamine, biotin, and nicotinic acid; Ca 2+ and Mg 2+ ; and guanine and uracil. In this study, different nutrient components were primarily used at different phase. Trp, Tyr, calcium pantothenate, thiamine, guanine, and Mg 2+ were mainly used from late‐lag to midexponential phase. Met, Pro, Phe, Ala, Gly, nicotinic acid, and riboflavin were mainly used from midexponential to late‐exponential phase. The highest bioavailabilities of nutrient components were also found at diverse phase. Met, Leu, Ile, Asn, Glu, Lys, Pro, Gly, riboflavin, nicotinic acid, adenine, uracil, inosine, and Ca 2+ had the highest bioavailability from late‐lag to midexponential phase. Lactose, Glu, Asp, His, Trp, Cys, Val, Arg, Phe, Ala, Ser, Thr, Tyr, folate and cobalamin, calcium pantothenate, ascorbic acid, thiamine, biotin, p ‐amino benzoic acid, vitamin B 6 , K + , Mg 2+ , guanine, xanthine, and PO 4 3− had the highest bioavailability from midexponential to late‐exponential phase. This study elucidated the nutrient requirement profiles with culture time and biomass at various average growth rates during the growth of S. thermophilus . The present results will help to formulate complex media for high cell density cultivation and provide the theoretical basis for S. thermophilus feeding strategies.
    Type of Medium: Online Resource
    ISSN: 2045-8827 , 2045-8827
    URL: Issue
    URL: Article
    DOI: 10.1002/mbo3.2019.8.issue-2
    DOI: 10.1002/mbo3.633
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2661368-2
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  • 8
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    Online Resource
    Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy
    Wiley ; 2020
    In:  Journal of Cellular Physiology Vol. 235, No. 1 ( 2020-01), p. 232-244
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 1 ( 2020-01), p. 232-244
    Abstract: Diabetes is often accompanied by dysfunction of salivary glands. However, the molecular mechanism remains unclear. The mechanisms that underlie diabetic hyposalivation were studied by db/db mice and SMG‐C6 cells. We found morphological changes and decreased stimulated salivary flow rates of the submandibular gland (SMG) in diabetic mice. We observed structural changes and dysfunction of mitochondria. More mitophagosomes and higher expression of autophagy‐related proteins were detected. Increased levels of proteins PINK1 and Parkin indicate that PINK1/Parkin‐mediated mitophagy was activated in diabetic SMG. Consistently, high glucose (HG) induced mitochondrial dysfunction and PINK1/Parkin‐mediated mitophagy in cultivated SMG‐C6 cells. HG also increased reactive oxygen species (ROS) and lessened activation of antioxidants in SMG‐C6 cells. In addition, HG lowered ERK1/2 phosphorylation and HG‐induced mitophagy was decreased after ERK1/2 was activated by LM22B‐10. Altogether, these data suggest that ROS played a crucial role in diabetes‐induced mitochondrial dysfunction and PINK1/Parkin‐mediated mitophagy and ERK1/2 was required in HG‐induced mitophagy in SMG.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v235.1
    DOI: 10.1002/jcp.28962
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478143-8
    detail.hit.zdb_id: 3116-1
    SSG: 12
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  • 9
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    Methotrexate and cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis: A single arm, single center, prospective phase 2 study
    Wiley ; 2020
    In:  American Journal of Hematology Vol. 95, No. 9 ( 2020-09)
    Details
    In: American Journal of Hematology, Wiley, Vol. 95, No. 9 ( 2020-09)
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v95.9
    DOI: 10.1002/ajh.25864
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 196767-8
    detail.hit.zdb_id: 1492749-4
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  • 10
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    ChemInform Abstract: A Hg(ClO 4 ) 2 ·3H 2 O‐Catalyzed Sakurai—Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane.
    Wiley ; 2012
    In:  ChemInform Vol. 43, No. 16 ( 2012-04-17)
    Details
    In: ChemInform, Wiley, Vol. 43, No. 16 ( 2012-04-17)
    Abstract: A wide range of substituted isatins is allylated under aerobic conditions using Hg(ClO 4 ) 2 ·3H 2 O.
    Type of Medium: Online Resource
    ISSN: 0931-7597 , 1522-2667
    URL: Issue
    URL: Article
    DOI: 10.1002/chin.v43.16
    DOI: 10.1002/chin.201216109
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 90598-7
    detail.hit.zdb_id: 2110203-X
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