In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 3 ( 2023-3-16), p. e1011266-
Abstract:
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved signaling pathway that can regulate various biological processes. However, the role of JAK-STAT pathway in the persistent viral infection in insect vectors has rarely been investigated. Here, using a system that comprised two different plant viruses, Rice stripe virus (RSV) and Rice black-streaked dwarf virus (RBSDV), as well as their insect vector small brown planthopper, we elucidated the regulatory mechanism of JAK-STAT pathway in persistent viral infection. Both RSV and RBSDV infection activated the JAK-STAT pathway and promoted the accumulation of suppressor of cytokine signaling 5 (SOCS5), an E3 ubiquitin ligase regulated by the transcription factor STAT5B. Interestingly, the virus-induced SOCS5 directly interacted with the anti-apoptotic B-cell lymphoma-2 (BCL2) to accelerate the BCL2 degradation through the 26S proteasome pathway. As a result, the activation of apoptosis facilitated persistent viral infection in their vector. Furthermore, STAT5B activation promoted virus amplification, whereas STAT5B suppression inhibited apoptosis and reduced virus accumulation. In summary, our results reveal that virus-induced JAK-STAT pathway regulates apoptosis to promote viral infection, and uncover a new regulatory mechanism of the JAK-STAT pathway in the persistent plant virus transmission by arthropod vectors.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011266
DOI:
10.1371/journal.ppat.1011266.g001
DOI:
10.1371/journal.ppat.1011266.g002
DOI:
10.1371/journal.ppat.1011266.g003
DOI:
10.1371/journal.ppat.1011266.g004
DOI:
10.1371/journal.ppat.1011266.g005
DOI:
10.1371/journal.ppat.1011266.g006
DOI:
10.1371/journal.ppat.1011266.g007
DOI:
10.1371/journal.ppat.1011266.s001
DOI:
10.1371/journal.ppat.1011266.s002
DOI:
10.1371/journal.ppat.1011266.s003
DOI:
10.1371/journal.ppat.1011266.s004
DOI:
10.1371/journal.ppat.1011266.s005
DOI:
10.1371/journal.ppat.1011266.s006
DOI:
10.1371/journal.ppat.1011266.s007
DOI:
10.1371/journal.ppat.1011266.s008
DOI:
10.1371/journal.ppat.1011266.s009
DOI:
10.1371/journal.ppat.1011266.s010
DOI:
10.1371/journal.ppat.1011266.r001
DOI:
10.1371/journal.ppat.1011266.r002
DOI:
10.1371/journal.ppat.1011266.r003
DOI:
10.1371/journal.ppat.1011266.r004
DOI:
10.1371/journal.ppat.1011266.r005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2205412-1
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