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  • Wiley  (73)
  • Zhang, Y.  (73)
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  • 1
    Online Resource
    Online Resource
    Hemorrhagic patterns and their risk factors in patients with moyamoya disease
    Wiley ; 2020
    In:  European Journal of Neurology Vol. 27, No. 12 ( 2020-12), p. 2499-2507
    Details
    In: European Journal of Neurology, Wiley, Vol. 27, No. 12 ( 2020-12), p. 2499-2507
    Abstract: The aim was to describe the profiles of hemorrhagic patterns of moyamoya disease (MMD) and analyze the risk factors in a large population. Methods A total of 335 conservatively managed MMD patients with hemorrhage in our hospital were included in this cross‐sectional study. The correlation between clinical and angiographic characteristics and hemorrhagic patterns (anterior or posterior hemorrhage) was assessed in the hemorrhagic hemisphere by univariate and multivariate logistic regression models. In addition, stratified analysis was performed. Results The 335 hemorrhagic hemispheres (patients) comprised 179 (53.4%) anterior and 156 (46.6%) posterior hemorrhages. For all cases, age at onset [odds ratio (OR) 0.98; 95% confidence interval (CI) 0.96–1.00; P  = 0.048] and choroidal anastomosis (OR 1.87; 95% CI 1.19–2.94; P =  0.007) were found by multivariate regression analysis to be negatively and positively associated with a significantly increased risk of posterior hemorrhage, respectively. After stratified analysis, hypertension (OR 0.37; 95% CI 0.14–0.97; P =  0.043) was identified by multivariate regression analysis as a risk factor for anterior hemorrhage in patients without dilation of choroidal anastomosis. On the other hand, choroidal anastomosis (OR 2.62; 95% CI 1.02–6.72; P =  0.045) and involvement of the posterior cerebral artery (OR 3.39; 95% CI 1.20–9.63; P =  0.022) were associated with significantly increased risk of posterior hemorrhage in children and young adults ( 〈 30 years of age). Conclusions A dynamic change in hemorrhagic patterns in MMD patients with increasing age at onset was observed. Choroidal anastomosis is a predictor of posterior hemorrhage. Hypertension is a risk factor for anterior hemorrhage in patients without extreme dilation of choroidal anastomosis.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v27.12
    DOI: 10.1111/ene.14477
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020241-6
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  • 2
    Online Resource
    Online Resource
    Heterogeneous nuclear ribonucleoprotein E1 regulates protein disulphide isomerase translation in oxidized low‐density lipoprotein‐activated endothelial cells
    Wiley ; 2015
    In:  Acta Physiologica Vol. 213, No. 3 ( 2015-03), p. 664-675
    Details
    In: Acta Physiologica, Wiley, Vol. 213, No. 3 ( 2015-03), p. 664-675
    Abstract: Endothelium‐derived protein disulphide isomerase (PDI) is required for thrombus formation in vivo . But, how to control PDI overproduction in oxidized low‐density lipoprotein (oxLDL)‐activated vascular endothelial cells (VECs) is not well understood. In this study, we try to answer this question using our newly identified activator of mTOC1 3‐benzyl‐5‐((2‐nitrophenoxy) methyl)‐dihydrofuran‐2 (3H)‐one (3BDO) that has been shown to protect VECs. Methods First, we performed a proteomics analysis on the ox LDL ‐activated vascular VEC s in the presence or absence of 3 BDO . Next, we constructed the heterogeneous nuclear ribonucleoprotein E1 (hn RNP E1) mutants at Ser43 and used the RNA ‐Ch IP technique to investigate the relationship between hn RNP E1 and PDI production. Furthermore, we examined the effect of 3 BDO on ox LDL ‐altered phosphorylation of Akt1 and Akt2. Finally, we studied the effect of 3 BDO on ox LDL ‐altered PDI protein level in apolipoprotein E −/− mice with advanced atherosclerosis. Results In VEC s, ox LDL ‐increased PDI protein level, induced hn RNP E1 phosphorylation at Ser43, suppressed the binding of hn RNP E1 to PDI 5′ UTR and induced the phosphorylation of Akt2 but not Akt1. All of these processes were blocked by 3 BDO . Importantly, Ser43 mutant of hn RNP E1 inhibited the increase of PDI protein level and the decrease of the binding of hn RNP E1 and PDI 5′ UTR induced by ox LDL . Furthermore, 3 BDO suppressed ox LDL ‐induced PDI protein increase in the serum and plaque endothelium of apolipoprotein E −/− mice. Conclusion hn RNP E1 is a new regulator of PDI translation in ox LDL ‐activated VEC s, and 3 BDO is a powerful agent for controlling PDI overproduction.
    Type of Medium: Online Resource
    ISSN: 1748-1708 , 1748-1716
    URL: Issue
    URL: Article
    DOI: 10.1111/apha.2015.213.issue-3
    DOI: 10.1111/apha.12422
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2617148-X
    detail.hit.zdb_id: 2219379-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia : Effect of HUVECs on PDLSC osteogenesis under hypoxia
    Wiley ; 2013
    In:  Journal of Periodontal Research Vol. 48, No. 1 ( 2013-02), p. 52-65
    Details
    In: Journal of Periodontal Research, Wiley, Vol. 48, No. 1 ( 2013-02), p. 52-65
    Type of Medium: Online Resource
    ISSN: 0022-3484
    URL: Issue
    URL: Article
    DOI: 10.1111/jre.2012.48.issue-1
    DOI: 10.1111/j.1600-0765.2012.01503.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2025633-4
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  • 4
    Online Resource
    Online Resource
    Regulatory network analysis of LINC00472 , a long noncoding RNA downregulated by DNA hypermethylation in colorectal cancer
    Wiley ; 2018
    In:  Clinical Genetics Vol. 93, No. 6 ( 2018-06), p. 1189-1198
    Details
    In: Clinical Genetics, Wiley, Vol. 93, No. 6 ( 2018-06), p. 1189-1198
    Abstract: Colorectal cancer (CRC), one of the common malignant cancers in the world, is caused by accumulated alterations of genetic and epigenetic factors over a long period of time. Along with that protein‐coding genes being identified as oncogenes or tumor suppressors in CRC, a number of lncRNAs have also been found to be associated with CRC. Considering the important regulatory role of lncRNAs, the first goal of this study was to identify CRC‐associated lncRNAs from a public database. One such lncRNA, LINC00472 , was verified to be downregulated in CRC cell lines and cancer tissues compared with adjacent tissues. In addition, the down‐regulation of LINC00472 seemed to be caused by DNA hypermethylation at its promoter region. Furthermore, the expression of LINC00472 and DNA methylation of promoter were significantly correlated with clinicopathological features. And DNA hypermethylation of LINC00472 may serve as a better diagnostic biomarker than its expression for CRC. Finally, we predicted the functions of LINC00472 and constructed a regulatory network and found LINC00472 may be involved in cell cycle and cell proliferation processes. Our results may provide a clue to further research into the function and regulatory mechanism of LINC00472 in CRC.
    Type of Medium: Online Resource
    ISSN: 0009-9163 , 1399-0004
    URL: Issue
    URL: Article
    DOI: 10.1111/cge.2018.93.issue-6
    DOI: 10.1111/cge.13245
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2004581-5
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  • 5
    Online Resource
    Online Resource
    Association of ideal cardiovascular health metrics and cognitive functioning: the APAC study
    Wiley ; 2016
    In:  European Journal of Neurology Vol. 23, No. 9 ( 2016-09), p. 1447-1454
    Details
    In: European Journal of Neurology, Wiley, Vol. 23, No. 9 ( 2016-09), p. 1447-1454
    Abstract: Previous studies have demonstrated that the components of ideal cardiovascular health (CVH) metrics are related to dementia. This study aimed to investigate the overall effects of ideal CVH metrics on cognitive functioning. Methods Information was collected on the seven ideal CVH metrics (smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol and fasting blood glucose) from the Asymptomatic Polyvascular Abnormalities Community study, and cognitive functioning was assessed by the score of the Mini‐Mental State Examination (MMSE). Multivariate logistic regression and linear regression models were used to assess the relationships between ideal CVH metrics and cognitive functioning. Results A total of 3260 (56.7% men) patients were included in this study. After adjusting for potential confounding factors, the associations between the number or score of ideal CVH metrics and cognitive impairment remained significant [odds ratio (OR) (95% confidence interval) 0.773 (0.664–0.928) and 0.904 (0.831–0.983), respectively]. In addition, there were significant linear relationships between the number or score of CVH metrics and the score of the MMSE ( β = 0.211 and 0.134 respectively, P 〈 0.001). Conclusions A clear inverse association was observed between the number or score of ideal CVH metrics and cognitive impairment in a Chinese population, supporting the importance of ideal CVH metrics in prevention of dementia.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.2016.23.issue-9
    DOI: 10.1111/ene.13056
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2020241-6
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  • 6
    Online Resource
    Online Resource
    Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis
    Wiley ; 2019
    In:  European Journal of Neurology Vol. 26, No. 10 ( 2019-10), p. 1296-
    Details
    In: European Journal of Neurology, Wiley, Vol. 26, No. 10 ( 2019-10), p. 1296-
    Abstract: Low‐density‐lipoprotein‐receptor‐associated protein 4 (LRP4) autoantibodies have recently been detected in myasthenia gravis (MG), but little is known about the clinical characteristics associated with this serological type. In this study, the clinical features of Chinese patients with anti‐LRP4 antibody‐positive MG were characterized. Methods A total of 2172 MG serum samples were collected from patients in various parts of China. An enzyme‐linked immunosorbent assay was used to detect acetylcholine receptor (AChR) antibody and titin antibody, and cell‐based assays were used to detect muscle‐specific kinase antibody and LRP4 antibody. Clinical data for patients with MG were collected from different provinces in China. Results In total, 16 (0.8%) patients with LRP4‐MG were found amongst 2172 total patients, including three patients with AChR/LRP4‐MG. Additionally, 13 (2.9%) patients with LRP4‐MG were found amongst 455 patients with double seronegative MG. The ratio of males to females for these 13 patients was 1:1.6, and 53.8% patients were children. A total of 91.7% of cases exhibited initial ocular involvement, and 58.3% of cases exhibited simple eye muscle involvement. Responses to acetylcholinesterase inhibitors and prednisone were observed. Conclusion The expanded sample confirmed that the positive rate of LRP4 antibodies in China is lower than that in western countries. Our results highlighted the differences between LRP4‐MG and other antibody groups. Children and female patients with LRP4‐MG have a higher prevalence, often involving the ocular muscles and limb muscles. The clinical symptoms are mild, and satisfactory responses to treatment are often achieved.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v26.10
    DOI: 10.1111/ene.13979
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 7
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    Online Resource
    Angiographic characteristics in Moyamoya disease with the p.R4810K variant: a propensity score‐matched analysis
    Wiley ; 2020
    In:  European Journal of Neurology Vol. 27, No. 5 ( 2020-05), p. 856-863
    Details
    In: European Journal of Neurology, Wiley, Vol. 27, No. 5 ( 2020-05), p. 856-863
    Abstract: The p.R4810K variant was identified as a strong susceptibility in patients with Moyamoya disease (MMD). The aim of this study was to investigate the angiographic characteristics in MMD with the p.R4810K variant. Methods Angiographic characteristics were compared between patients with wild‐type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching, including Suzuki stage, collateral circulation and external carotid artery (ECA) collateral. Collateral circulation was graded with scores ranging from 0 to 12: posterior collateral circulation from the posterior cerebral artery to the middle cerebral artery and anterior cerebral artery was scored from 0 to 6; anterior collateral circulation was scored as 6 to 0 corresponding to Suzuki stages 0 to 6. Results A total of 489 patients were screened; 133 pairs were obtained after 1:1 propensity score matching. Compared with the patients in the GA group, unilateral MMD was more frequent in the GG group ( P  = 0.026). Hemispheres in the GA group (86/266) had more posterior cerebral artery involvement than hemispheres in the GG group (48/266) ( P   〈  0.001). Hemispheres in the GA group had a lower grade in collateral circulation than hemispheres in the GG group ( P  = 0.011), but ECA collateral was more frequently observed in the GA group than in the GG group (53.4% vs. 39.8%, P  = 0.002). Superficial temporal artery and occipital artery collateral was more frequently observed in the GA group than in the GG group ( P   〈  0.05). Conclusions Patients in the GA group had lower grades in collateral circulation than patients in the GG group, but ECA collateral was more frequently observed in the GA group than in the GG group.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v27.5
    DOI: 10.1111/ene.14184
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 8
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    Online Resource
    Prevalence and risk factors of asymptomatic intracranial arterial stenosis in a community‐based population of C hinese adults
    Wiley ; 2013
    In:  European Journal of Neurology Vol. 20, No. 11 ( 2013-11), p. 1479-1485
    Details
    In: European Journal of Neurology, Wiley, Vol. 20, No. 11 ( 2013-11), p. 1479-1485
    Abstract: Intracranial arterial stenosis ( ICAS ) is one of the most common causes of ischaemic stroke in A sia. Knowledge of the prevalence and risk factors of asymptomatic ICAS is limited. The prevalence of ICAS was therefore investigated and its risk factors in a C hinese community‐based population were explored. Methods From 2010 to 2011, a stratified (by sex and age) random sample of 5440 participants aged 40 years or older were enrolled in the study. ICAS was assessed using t ranscranial D oppler. Logistic regression was used to evaluate potential risk factors associated with ICAS in participants. Results In total, 13.2% (95% CI 12.3–14.1) of the subjects had ICAS , and women were more likely than men to have ICAS in the 40–49 year age group. Hypertension [odds ratio (OR) = 2.23, 95% CI 1.87–2.66], diabetes (OR = 1.99, 95% CI 1.62–2.45), left ventricular hypertrophy (OR = 1.66, 95% CI 1.18–2.34) and elevated high‐sensitivity C‐reactive protein (OR = 1.55, 95% CI 1.19–2.02) were independently associated with higher prevalence of ICAS after adjusting for age, gender, body mass index, smoking status and other covariates. Of the 716 ICAS individuals, 90.6% had one or more of these risk factors. Amongst the subjects who had at least one risk factor, 15.2% had ICAS . Conclusions Intracranial artery stenosis is common in the Chinese population. Individuals who had one or more risk factors were more likely to have ICAS , suggesting more aggressive risk factor management.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.2013.20.issue-11
    DOI: 10.1111/ene.12210
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2020241-6
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  • 9
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    Online Resource
    The basic physics of the binary black hole merger GW150914
    Wiley ; 2017
    In:  Annalen der Physik Vol. 529, No. 1-2 ( 2017-01)
    Details
    In: Annalen der Physik, Wiley, Vol. 529, No. 1-2 ( 2017-01)
    Abstract: The first direct gravitational‐wave detection was made by the Advanced Laser Interferometer Gravitational Wave Observatory on September 14, 2015. The GW150914 signal was strong enough to be apparent, without using any waveform model, in the filtered detector strain data. Here, features of the signal visible in the data are analyzed using concepts from Newtonian physics and general relativity, accessible to anyone with a general physics background. The simple analysis presented here is consistent with the fully general‐relativistic analyses published elsewhere, in showing that the signal was produced by the inspiral and subsequent merger of two black holes. The black holes were each of approximately , still orbited each other as close as ∼350 km apart and subsequently merged to form a single black hole. Similar reasoning, directly from the data, is used to roughly estimate how far these black holes were from the Earth, and the energy that they radiated in gravitational waves.
    Type of Medium: Online Resource
    ISSN: 0003-3804 , 1521-3889
    URL: Issue
    URL: Article
    DOI: 10.1002/andp.v529.1-2
    DOI: 10.1002/andp.201600209
    RVK:
    UA 2050
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1479791-4
    detail.hit.zdb_id: 2165600-9
    detail.hit.zdb_id: 287-2
    SSG: 25
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  • 10
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    Antidiarrheal effect of bioactivity‐guided fractions and bioactive components of pomegranate ( Punica granatum L.) peels
    Wiley ; 2018
    In:  Neurogastroenterology & Motility Vol. 30, No. 7 ( 2018-07)
    Details
    In: Neurogastroenterology & Motility, Wiley, Vol. 30, No. 7 ( 2018-07)
    Abstract: Pomegranate peels have been widely used to treat diarrhea in China. The antidiarrheal activities of aqueous extracts of pomegranate peels have been evaluated. However, there have not been any bioactivity‐guided fractionation studies on the antidiarrheal effect to identify the bioactive components of the extract. Methods Bioactivity‐guided fractionation of an aqueous extract of pomegranate peels was performed using different solvents of increasing polarity, generating fractions dissolved in ethyl acetate, n ‐butyl alcohol, and the residual fraction. The principal chemical composition of the active fraction was analyzed by HPLC / ESI ‐ MS . Key Results Fecal frequencies revealed that only the ethyl acetate fraction possessed significant antidiarrheal activity. Furthermore, administration of the ethyl acetate fraction at 100, 200, and 400 mg/kg significantly reduced gastrointestinal transit in charcoal meal tests in mice. It also significantly inhibited castor oil‐induced enteropooling compared to control animals. Histopathological analysis revealed that small intestine lesions of mice treated with the ethyl acetate fraction were alleviated compared to those in mice treated with castor oil. The ethyl acetate fraction was found to be composed mainly of punicalagin, corilagin, and ellagic acid, and a combination of these compounds could mediate the antidiarrheal activities. Conclusion and Inferences Our study describes the protective effects of pomegranate peels against castor oil‐induced diarrhea. The findings showed that the ethyl acetate fraction was the active fraction of pomegranate peels, of which punicalagin, corilagin, and ellagic acid were responsible for the antidiarrheal effect of aqueous extracts.
    Type of Medium: Online Resource
    ISSN: 1350-1925 , 1365-2982
    URL: Issue
    URL: Article
    DOI: 10.1111/nmo.2018.30.issue-7
    DOI: 10.1111/nmo.13364
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008278-2
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