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  • Wiley  (6)
  • Zhang, Y.  (6)
  • 2020-2024  (6)
Materialart
Verlag/Herausgeber
  • Wiley  (6)
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  • 2020-2024  (6)
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Fachgebiete(RVK)
  • 1
    In: Angewandte Chemie, Wiley, Vol. 135, No. 10 ( 2023-03)
    Kurzfassung: The development of high mobility emissive organic semiconductors is of great significance for the fabrication of miniaturized optoelectronic devices, such as organic light emitting transistors. However, great challenge exists in designing key materials, especially those who integrates triplet exciton utilization ability. Herein, dinaphthylanthracene diimides (DNADIs), with 2,6‐extended anthracene donor, and 3′‐ or 4′‐substituted naphthalene monoimide acceptors were designed and synthesized. By introducing acceptor‐donor‐acceptor structure, both materials show high electron mobility. Moreover, by fine‐tuning of substitution sites, good integration with high solid state photoluminescence quantum yield of 26 %, high electron mobility of 0.02 cm 2  V −1  s −1 , and the feature of hot‐exciton induced delayed fluorescence were obtained in 4′‐DNADI. This work opens a new avenue for developing high electron mobility emissive organic semiconductors with efficient utilization of triplet excitons.
    Materialart: Online-Ressource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 505868-5
    ZDB Id: 506609-8
    ZDB Id: 514305-6
    ZDB Id: 505872-7
    ZDB Id: 1479266-7
    ZDB Id: 505867-3
    ZDB Id: 506259-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 10 ( 2023-03)
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 10 ( 2023-03)
    Kurzfassung: The development of high mobility emissive organic semiconductors is of great significance for the fabrication of miniaturized optoelectronic devices, such as organic light emitting transistors. However, great challenge exists in designing key materials, especially those who integrates triplet exciton utilization ability. Herein, dinaphthylanthracene diimides (DNADIs), with 2,6‐extended anthracene donor, and 3′‐ or 4′‐substituted naphthalene monoimide acceptors were designed and synthesized. By introducing acceptor‐donor‐acceptor structure, both materials show high electron mobility. Moreover, by fine‐tuning of substitution sites, good integration with high solid state photoluminescence quantum yield of 26 %, high electron mobility of 0.02 cm 2  V −1  s −1 , and the feature of hot‐exciton induced delayed fluorescence were obtained in 4′‐DNADI. This work opens a new avenue for developing high electron mobility emissive organic semiconductors with efficient utilization of triplet excitons.
    Materialart: Online-Ressource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2011836-3
    ZDB Id: 123227-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Animal Genetics, Wiley, Vol. 53, No. 1 ( 2022-02), p. 137-141
    Kurzfassung: Embryo loss is an important factor affecting fertility in dairy production. HH2 was identified as a haplotype on chromosome 1 associated with embryonic lethality in Holstein cattle. In the current study, both short‐ and long‐read WGS was performed on four carriers and four non‐carriers of HH2 to screen for variants in concordance with HH2 haplotype status. Sequence variation analysis revealed five putative functional variants of protein‐coding genes, including a frameshift mutation (g.107172616delT) in intraflagellar transport protein 80 ( IFT80 ) gene. Transcriptome analysis of whole blood indicated that no gene exhibited significantly differential expression or allele‐specific expression between carriers and non‐carriers in the candidate region. This evidence points to g.107172616delT as the highest priority causative mutation for HH2. Protein prediction reveals that the frameshift mutation results in a premature stop codon to reduce the peptide chain from 760 to 383 amino acids and greatly alters the structure and function of IFT80 protein. Our results demonstrate that the use of a combination of multiple high‐throughput sequencing technologies is an efficient strategy to screen for the candidate causative mutations responsible for Mendelian traits, including genetic disorders.
    Materialart: Online-Ressource
    ISSN: 0268-9146 , 1365-2052
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 1472889-8
    SSG: 22
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Wiley ; 2021
    In:  European Journal of Neurology Vol. 28, No. 2 ( 2021-02), p. 630-638
    In: European Journal of Neurology, Wiley, Vol. 28, No. 2 ( 2021-02), p. 630-638
    Kurzfassung: Small‐fiber nerves are the first to be involved in transthyretin familial amyloid polyneuropathy (TTR‐FAP) patients. In vivo corneal confocal microscopy (CCM) is a noninvasive technique to detect small‐fiber polyneuropathy (SFN) by quantifying corneal nerve morphology. The characteristic whorl‐like pattern of the corneal nerve provides a static landmark for observation. We aimed to evaluate whether CCM images of the whorl‐like plexus can sensitively evaluate and monitor disease progression in FAP patients. Methods Fifteen FAP patients and 15 controls underwent neurological evaluation and CCM observation. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) detected by conventional method and inferior whorl length (IWL), inferior whorl fiber density (IWFD), and inferior whorl branch density (IWBD) were compared in controls and patients. The Langerhans cell (LC) density in each image was calculated. Results All CCM parameters were significantly reduced with disease progression. Preclinical patients had significantly lower IWL ( P =  0.008) than age‐matched controls. IWL ( P  = 0.006), CNFL ( P  = 0.005), CNBD ( P  = 0.008), and CNFD ( P  = 0.014) were significantly lower in early‐phase patients. LC density was significantly increased around the central whorl in early‐phase patients and was relatively lower in progressive patients. Both IWL and CNFL correlated with the severity of neuropathy, and IWL was more significantly reduced. The area under the receiver operating characteristic (ROC) curve for FAP with CNFL and IWL was 88.0% (95% CI, 70.9%–96.9%) and 89.3% (95% CI, 72.6%–97.6%), respectively, exceeding other parameters. Conclusions IWL is a more sensitive surrogate to detect preclinical SFN in FAP and can best discriminate patients from controls. The clustering of immature LCs at the inferior whorl area might reflect the inflammatory response of small‐fiber nerves at the early stage.
    Materialart: Online-Ressource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2020241-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Wiley ; 2020
    In:  International Endodontic Journal Vol. 53, No. 1 ( 2020-01), p. 111-121
    In: International Endodontic Journal, Wiley, Vol. 53, No. 1 ( 2020-01), p. 111-121
    Kurzfassung: To investigate the stress distribution and tooth displacement of a maxillary central incisor with various apical root resection lengths and occlusal relationships using finite element (FE) analysis. Methodology A maxillary central incisor was scanned by micro‐CT. First, the FE intact incisor model with dentine, enamel, pulp and root surrounded by alveolar bone and periodontal ligament was designed based on the micro‐CT image data. Then, six FE models with varying lengths of apical root resection were established to simulate the clinical treatment and reveal the clinically applicable limit of apical root resection during endodontic microsurgery. For each model under different loading conditions, the maximum von Mises stress (σ max) at the root apex, root cervix, alveolar bone and periodontal ligament and the maximum tooth displacement (Δ R max) were calculated and compared. Results In a normal occlusion, more than 6 mm of root resection resulted in a marked increase in the Δ R max values ( 〉 10%) and σ max values of alveolar bone ( 〉 50%); the stress levels at the root apex increased dramatically when the apical root was resected more than 7 mm. With increased overjet, apical root resection did not change the stress level markedly until it reached 8 mm, but the Δ R max increased markedly ( 〉 10%) if the root was resected more than 5 mm. With deep overbites, the σ max increased significantly ( 〉 50%) when the root was resected more than 4 mm whilst the Δ R max decreased. With increased overjet and deep overbite, more than 6 mm of resection resulted in a substantial σ max increase ( 〉 50%) of alveolar bone and the Δ R max increased markedly ( 〉 10%) when the root was resected 8 mm. Additionally, the σ max and the Δ R max values were greater with increased overjet and lower with deep overbites. Conclusions Using FE analysis, apical root resection of more than 6 mm resulted in a marked increase of stress distribution and tooth displacement in normal and increased overjet with deep overbite occlusal relationships. In increased overjets or deep overbites, more than 5 mm or 4 mm, respectively, stress distribution and tooth displacement increased markedly.
    Materialart: Online-Ressource
    ISSN: 0143-2885 , 1365-2591
    URL: Issue
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2020
    ZDB Id: 2020354-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Wiley ; 2021
    In:  International Endodontic Journal Vol. 54, No. 2 ( 2021-02), p. 241-254
    In: International Endodontic Journal, Wiley, Vol. 54, No. 2 ( 2021-02), p. 241-254
    Kurzfassung: To investigate the effect of miR‐223 on NLRP3, subsequently regulating the production of the NLRP3/CASP1 inflammasome pathway‐mediated proinflammatory cytokines IL‐1β and IL‐18 in human dental pulp fibroblasts (HDPFs). Methodology Human dental pulp tissue (HDPT) and HDPFs were obtained from impacted third molars. The miR‐223 mimics and inhibitor or NLRP3 plasmid were used to upregulate or downregulate miR‐223 or NLRP3 in HDPFs, respectively. Computational prediction via TargetScan 5.1 and a luciferase reporter assay was conducted to confirm target association. The mRNA and protein expression of NLRP3, caspase‐1, IL‐1β and IL‐18 was determined by qRT‐PCR and Western blotting, respectively. The release of IL‐1β and IL‐18 was analysed by ELISA. The significance of the differences between the experimental and the control groups was determined using one‐way analysis of variance; P   〈  0.05 indicated statistical significance. Results A decrease in miR‐223 and an increase in NLRP3 in HDPT occurred during the transformation of reversible pulpitis into irreversible pulpitis compared to that in healthy pulp tissue ( P   〈  0.05). The computational prediction and luciferase reporter assay confirmed that NLRP3 was a direct target of miR‐223 in HDPFs. The miR‐223 inhibitor further promoted ATP plus LPS‐induced NLRP3/CASP1 inflammasome pathway activation compared to the ATP plus LPS‐induced group ( P   〈  0.05). In contrast, the miR‐223 mimic significantly inhibited the NLRP3/CASP1 inflammasome pathway activation induced by ATP plus LPS compared to the ATP plus LPS‐induced group ( P   〈  0.05). Conclusion MiR‐223 served as a negative regulator involved in the control of the production and secretion of proinflammatory cytokines mediated by the NLRP3/CASP1 inflammasome pathway by targeting NLRP3. These data provide insight into the potential regulatory effects of miRNAs on the NLRP3 inflammasome, thus opening up novel potential therapeutic avenues for future endodontic treatment.
    Materialart: Online-Ressource
    ISSN: 0143-2885 , 1365-2591
    URL: Issue
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2020354-8
    Standort Signatur Einschränkungen Verfügbarkeit
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