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  • SAGE Publications  (8)
  • Zhang, Xing  (8)
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  • SAGE Publications  (8)
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  • 1
    Online Resource
    Online Resource
    MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells
    SAGE Publications ; 2016
    In:  International Journal of Toxicology Vol. 35, No. 1 ( 2016-01), p. 17-26
    Details
    In: International Journal of Toxicology, SAGE Publications, Vol. 35, No. 1 ( 2016-01), p. 17-26
    Abstract: Biological oxidative responses are involved in the toxicity of multiwall carbon nanotubes (MWCNTs), which may cause asbestos-like pathogenicity. Superoxide dismutase 2 (SOD-2) has been proposed as a biomarker of early responses to mesothelioma-inducing fibers. This study was conducted to investigate the alteration of SOD-2 expression in the human mesothelial cell lines Met-5A after exposure to nontoxic doses of MWCNTs and the potential signaling pathway. The parameters measured included the viability, morphological change, superoxide formation, extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, and messenger RNA (mRNA)/protein levels of SOD-2. Our results showed that MWCNTs upregulated SOD-2 expression at both mRNA and protein level. Coincidently, both superoxide formation and ERK1/2 phosphorylation were observed in Met-5A cells exposed to MWCNTs and were diminished by pretreatment with the reactive oxidative species (ROS) scavenger, N-acetyl-l-(+)-cysteine (NAC). To further investigate the role of ROS/ERK1/2 in MWCNTs-induced SOD-2 overexpression, prior to MWCNTs exposure, cells were pretreated with the Mitogen-activated protein kinase kinase 1/2 (MEK 1/2) inhibitor (U0126) or with NAC. Both pretreatments decreased the MWCNTs-induced overexpression of SOD-2. These results suggest that upregulation of SOD-2 in Met-5A cells exposed to MWCNTs is mediated by ROS formation and ERK1/2 activation.
    Type of Medium: Online Resource
    ISSN: 1091-5818 , 1092-874X
    URL: Article
    DOI: 10.1177/1091581815591223
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1500682-7
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    Online Resource
  • 2
    Online Resource
    Online Resource
    The synergism between melamine and expandable graphite on improving the flame retardancy of polyamide 11
    SAGE Publications ; 2017
    In:  High Performance Polymers Vol. 29, No. 1 ( 2017-02), p. 77-86
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 29, No. 1 ( 2017-02), p. 77-86
    Abstract: Expandable graphite (EG) has attracted more and more attention in fire science society due to its excellent char-forming ability, however, it cannot meet commercial flame-retardant requirements because of the low intensity of the char. This work reported our very recent efforts on improving the char quality of EG by introducing melamine (MEL) in order to enhance the fire resistance and thermal stability of polyamide 11 (PA 11) composite. The flammability characterized by limiting oxygen index, UL-94 vertical burning, and cone calorimeter (cone) tests shows that the presence of both EG and MEL can significantly improve the flame retardancy and thermal stability of PA 11 composites. The scanning electron microscopic analysis shows that EG and MEL are beneficial to form compact char layers that can isolate the matrix from heat and oxygen. It is proposed that the formation of hydrogen bonds between MEL and PA 11 are crucial for improving the flame retardancy of the composites.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008316628965
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1483713-4
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Application of Taguchi Method in the Optimization of Swimming Capability for Robotic Fish
    SAGE Publications ; 2016
    In:  International Journal of Advanced Robotic Systems Vol. 13, No. 3 ( 2016-05-01), p. 102-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 13, No. 3 ( 2016-05-01), p. 102-
    Abstract: In this paper, we applied the Taguchi method to evaluate the maximum swimming speed of a robotic fish under the limitation of the output of the motor. Four factors were considered in the optimization: the caudal-fin aspect ratio, the caudal fin stiffness, the oscillating frequency and the stiffness of the spring that transmits forces from the actuators to the foil. Because of the power limitations, the parameter's space was irregular. Since the Taguchi method requires a regular parameter space, we divided the parameter space into a regular space and the remaining irregular spaces. Within only 25 trials, the frequency and the spring stiffness were determined as the main factors in the regular space by the orthogonal design. Six more trials were carried out in the remaining irregular space with a higher frequency and spring stiffness. The fastest swimming speed of 870 mm/s, approximately 2.6 BL ( Body Lengths)/ s, was acquired, when the frequency reached 12 Hz and with infinite spring stiffness. This method is efficient for exploring the maximum locomotor capabilities of robotic fish and may also be useful for other robots as no modelling is required.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.5772/64039
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2202393-8
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Association of the Geriatric Nutritional Risk Index with incident hypertension in the older Chinese population: a 6-year cohort study
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 5 ( 2021-05), p. 030006052110100-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 5 ( 2021-05), p. 030006052110100-
    Abstract: We examined the association of the Geriatric Nutritional Risk Index (GNRI) with the incidence of hypertension. Methods We used data of the China Health and Nutrition Survey in this study. Participants aged ≥60 years were eligible. The GNRI was defined as follows: GNRI = [1.489 × albumin (ALB; g/L)] + [41.7 × (actual weight/ideal weight)] . Participants with systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive medication were defined as having hypertension. Results This study included 4853 participants, comprising 3612 control participants and 1241 participants with hypertension. The GNRI, ALB, and body mass index (BMI) were significantly associated with higher incidence of hypertension (HR: 1.030, 1.026, and 1.088; 95% CI: 1.020–1.041, 1.008–1.044, and 1.069–1.107, respectively). The GNRI, ALB, and BMI were associated with an earlier age of hypertension onset (β = −0.403, −0.613, and −0.321; 95% CI: −0.493 to −0.314, −0.767 to −0.459, and −0.484 to −0.159, respectively). Conclusions A higher GNRI was associated with increased incidence of hypertension. An elevated GNRI was associated with earlier age of hypertension onset.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211010051
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Before and after the Chinese gene-edited human babies: Multiple discourses of gene editing on social media
    SAGE Publications ; 2021
    In:  Public Understanding of Science Vol. 30, No. 5 ( 2021-07), p. 570-587
    Details
    In: Public Understanding of Science, SAGE Publications, Vol. 30, No. 5 ( 2021-07), p. 570-587
    Abstract: This study examines discourses in Chinese online discussions of gene editing by multiple social actors on Weibo before and after a significant scientific crisis, the 2018 scandal of Chinese gene-edited human babies. A content analysis of 2074 posts was done to identify frames, emotions, and metaphors. Findings reveal that Chinese social media have opened up new spaces for multiple social actors to generate multiple discourses. This has resulted in a more participatory public engagement with science and technology on Chinese social media, potentially influencing the online agenda and policy decisions on science and technology. Finally, findings indicate that a scientific crisis can serve as a trigger for significant changes in public attitudes and opinions regarding gene editing.
    Type of Medium: Online Resource
    ISSN: 0963-6625 , 1361-6609
    URL: Article
    DOI: 10.1177/0963662520987754
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 33479-0
    detail.hit.zdb_id: 1421272-9
    SSG: 11
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Changing Social Representations and Agenda Interactions of Gene Editing After Crises: A Network Agenda-Setting Study on Chinese Social Media
    SAGE Publications ; 2022
    In:  Social Science Computer Review Vol. 40, No. 5 ( 2022-10), p. 1133-1152
    Details
    In: Social Science Computer Review, SAGE Publications, Vol. 40, No. 5 ( 2022-10), p. 1133-1152
    Abstract: By incorporating social representation theory with science communication and by using a critical milestone scientific crisis (i.e., the scandal of Chinese gene-edited human babies in 2018) as a dividing point, this study adopted a network agenda-setting approach to explore how various actors (i.e., scientists, the media, laypeople, and the government) engaged in the construction of social representations of the controversial issue of gene editing on Chinese social media (i.e., Sina Weibo). Based on large-scale social media data, supervised machine learning was employed to identify attribute categories, and semantic network analysis was used to construct attribute networks. Results reveal that after the 2018 crisis, gene editing received increasing social attention on Chinese social media. Further, two trends emerged in social representations of gene editing on social media: de-scientization and medialization. The following dynamic agenda interactions among various actors were found: On the one hand, the media and laypeople’s attribute network agendas converged while scientists and the media’s diverged after the scandal. This indicates a scientific crisis can serve as a trigger for agenda convergence and divergence among different actors online. On the other hand, there were constant agenda interactions, such as between the Chinese government and the media. This reveals a feature of Chinese science communication—the media not only mediates between scientists and the public, it also observes the government’s agenda closely when representing controversial scientific issues such as gene editing.
    Type of Medium: Online Resource
    ISSN: 0894-4393 , 1552-8286
    URL: Article
    DOI: 10.1177/0894439321998066
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2021894-1
    SSG: 3,4
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    Online Resource
  • 7
    Online Resource
    Online Resource
    The Sagan Effect and Scientists’ Public Outreach Participation in China: Multilayered Roles of Social Norms and Rewards
    SAGE Publications ; 2023
    In:  Science Communication Vol. 45, No. 1 ( 2023-02), p. 12-38
    Details
    In: Science Communication, SAGE Publications, Vol. 45, No. 1 ( 2023-02), p. 12-38
    Abstract: In this study, we investigate public outreach participation among Chinese scientists through a multiple mediation model. Factors related to the Sagan effect—negative experiences and negative personal norms—are examined as potential predictors and/or mediators. Based on a national survey of 8,533 scientists, we validate the Sagan effect triggered by their negative experiences, which indirectly inhibit their outreach participation intentions through negative personal norms. Moreover, positive social norms and rewards play multilayered roles in mitigating the Sagan effect and improving such intentions. This study provides a more comprehensive examination of the underlying mechanisms behind scientists’ willingness to engage with the public.
    Type of Medium: Online Resource
    ISSN: 1075-5470 , 1552-8545
    URL: Article
    DOI: 10.1177/10755470221143077
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1209835-8
    detail.hit.zdb_id: 2014915-3
    SSG: 25
    SSG: 3,4
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    Online Resource
  • 8
    Online Resource
    Online Resource
    How will actual wearing time influence the protective effect of surgical masks?
    SAGE Publications ; 2023
    In:  Textile Research Journal Vol. 93, No. 7-8 ( 2023-04), p. 1641-1650
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 93, No. 7-8 ( 2023-04), p. 1641-1650
    Abstract: The protection effects of wearing masks against viruses and bacteria have been verified many times over previous pandemics and infectious diseases. However, the supply of the surgical masks can barely meet the surging demand at the early stage (first 12 months) of the outbreak of a pandemic. Thus, it is essential to use surgical masks wisely in such urgent times. In this work, we selected two types of surgical masks and systematically explored how actual wearing time influences the protective performances of the masks. Each type of surgical masks was worn for 4, 10, 24, 32 and 48 h, respectively, and the results show that with the increase of actual wearing time, both particulate filtration efficiency (PFE) and bacterial filtration efficiency (BFE) of the masks decline. After wearing for 32 h, the PFEs of both types of masks were still far above the corresponding standard (≥30%, according to YY0469-2011). After wearing for 10 h, the BFEs of both masks were over 95% (which is regarded as the safe value), whereas after 24 and 32 h of wearing, the BFE of one type of mask decreased obviously to 91.6% and 80.0%, respectively. Based on these results, it is rational to conclude that the wearing time of surgical masks should be no more than 10 h.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175221131065
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2209596-2
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