In:
International Journal of Cancer, Wiley, Vol. 145, No. 4 ( 2019-08-15), p. 952-961
Abstract:
What's new? Glioblastomas (GBMs) and lower‐grade gliomas (LGGs) are the most common malignant brain tumors. Despite extensive studies reporting differences between the two in terms of clinical profile and treatment, to date their distinction on a molecular level has not been systematically analyzed. Here, the authors integrated multi‐dimensional data‐‐including somatic mutations, somatic copy number variants, gene expression, lncRNA expression, and DNA methylation levels‐‐to globally depict the distinction between LGG and GBM. Moreover, they identified some key GBM‐ and LGG‐specific genes featuring multiple‐level molecular alterations and found that GBM‐specific genes were strongly related to the glioma pathway.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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