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  • Hindawi Limited  (22)
  • Zhang, Xiaohong  (22)
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  • Hindawi Limited  (22)
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  • 1
    Online Resource
    Online Resource
    Does Body Mass Index and Height Influence the Incident Risk of Ischemic Stroke in Newly Diagnosed Type 2 Diabetes Subjects?
    Hindawi Limited ; 2019
    In:  Journal of Diabetes Research Vol. 2019 ( 2019-01-22), p. 1-8
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2019 ( 2019-01-22), p. 1-8
    Abstract: Objective . To estimate the incident risk of ischemic stroke (IS) in newly diagnosed type 2 diabetes (T2D) subjects according to different body mass index (BMI) and height categories. Methods . A total of 25,130 newly diagnosed T2D subjects were included in this study. All T2D subjects were enrolled consecutively from the Chronic Disease Surveillance System (CDSS) of Ningbo. Standardized incidence ratio (SIR) and its 95% confidence interval (95% CI) stratified by BMI categories and height quartiles were used to estimate the incident risk of IS in T2D subjects. Results . In total, 22,795 subjects completed the follow-up. Among them, 1268 newly diagnosed IS cases were identified, with 149,675 person-years. The SIRs of normal BMI (18.5–24.0 kg/m 2 ), overweight (24.0–28.0 kg/m 2 ), and obese (≥28.0 kg/m 2 ) in overall subjects were 2.56 (95% CI 1.90–3.13), 2.13 (95% CI 1.90–3.13), and 1.87 (95% CI 1.29–2.43), respectively ( P t r e n d 〈 0.01 ), comparing to the general population of Ningbo. For each 1 kg/m 2 increment in BMI, the SIR was 0.948 (95% CI 0.903–0.999). For height quartiles, the SIRs of male subjects in quartile 1 ( 〈 160 cm), quartile 2 (161–165 cm), quartile 3 (165–170 cm), and quartile 4 (≥171 cm) were 2.27 (95% CI 1.99–2.56), 2.01 (95% CI 1.67–2.45), 1.37 (95% CI 1.05–1.68), and 0.91 (95% CI 0.40–1.32), respectively ( P t r e n d 〈 0.01 ). While for female subjects, the SIRs in quartile 1 ( 〈 155 cm), quartile 2 (156–160 cm), quartile 3 (161–165 cm), and quartile 4 (≥166 cm) were 3.57 (95% CI 3.11–3.49), 2.96 (95% CI 2.61–3.31), 1.94 (95% CI 1.51–2.36), and 1.71 (95% CI 0.95–2.47), respectively ( P t r e n d 〈 0.01 ). Conclusion . Compared to the general population of Ningbo, T2D subjects had a higher incident risk of IS. Furthermore, the IS incident risk was not only higher in newly diagnosed T2D subjects with normal BMI but also lower in taller newly diagnosed T2D subjects.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2019/2591709
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2711897-6
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  • 2
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    Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses
    Hindawi Limited ; 2020
    In:  Cardiovascular Therapeutics Vol. 2020 ( 2020-08-01), p. 1-13
    Details
    In: Cardiovascular Therapeutics, Hindawi Limited, Vol. 2020 ( 2020-08-01), p. 1-13
    Abstract: Background . As a multifaceted disease, atherosclerosis is often characterized by the formation and accumulation of plaque anchored to the inner wall of the arteries and causes some cardiovascular diseases and vascular embolism. Numerous studies have reported on the pathogenesis of atherosclerosis. However, fewer studies focused on both genes and immune cells, and the correlation of genes and immune cells was evaluated via comprehensive bioinformatics analyses. Methods . 29 samples of atherosclerosis-related gene expression profiling, including 16 human advanced atherosclerosis plaque (AA) and 13 human early atherosclerosis plaque (EA) samples from the Gene Expression Omnibus (GEO) database, were analyzed to get differentially expressed genes (DEGs) and the construction of protein and protein interaction (PPI) networks. Besides, we detected the relative fraction of 22 immune cell types in atherosclerosis by using the deconvolution algorithm of “cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT).” Ultimately, based on the significantly changed types of immune cells, we executed the correlation analysis between DEGs and immune cells to discover the potential genes and pathways associated with immune cells. Results . We identified 17 module genes and 6 types of significantly changed immune cells. Correlation analysis showed that the relative percentage of T cell CD8 has negative correlation with the C1QB expression ( R = − 0.63 , p = 0.02 ), and the relative percentage of macrophage M2 has positive correlation with the CD86 expression ( R = 0.57 , p = 0.041 ) in EA. Meanwhile, four gene expressions ( CD53 , C1QC , NCF2 , and ITGAM ) have a high correlation with the percentages of T cell CD8 and macrophages (M0 and M2) in AA samples. Conclusions . In this study, we suggested that the progression of atherosclerosis might be related to CD86 , C1QB , CD53 , C1QC , NCF2 , and ITGAM and that it plays a role in regulating immune-competent cells such as T cell CD8 and macrophages M0 and M2. These results will enable studies of the potential genes associated with immune cells in the progression of atherosclerosis, as well as provide insight for discovering new treatments and drugs.
    Type of Medium: Online Resource
    ISSN: 1755-5914 , 1755-5922
    URL: Article
    DOI: 10.1155/2020/1230513
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2417088-4
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  • 3
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    Cellular and Molecular Evidence of Acetaldehyde Elimination and Intracellular Environment Antioxidation by L-Cysteine
    Hindawi Limited ; 2018
    In:  Journal of Chemistry Vol. 2018 ( 2018-09-24), p. 1-8
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2018 ( 2018-09-24), p. 1-8
    Abstract: Acetaldehyde is a harmful metabolite of smoking and drinking. This study was initially intended to facilitate the understanding of the possible injury mechanism of A549 cells damaged by acetaldehyde and the possible protective mechanism of L-cysteine (L-Cys) by analyzing the oxidative damage indicators, as well as the changes in cell morphology and gene expression. Results from the dithiodimorpholine nitrobenzoic acid colorimetric determination for glutathione peroxidase (GSH-Px) activity in L-Cys groups were significantly higher ( P 〈 0.01 ) than those in the acetaldehyde group in a dose-dependent manner. The expression of cytochrome c oxidase subunit II (COII) mRNA was significantly reduced compared with the control group ( P 〈 0.01 ) and was noticeably restored in the L-Cys groups. Scanning electronic microscopy observation, DAPI staining, and flow cytometry also indicated that L-Cys could effectively attenuate the oxidative damage to A549 cells caused by acetaldehyde and reduces the rate of apoptosis. In conclusion, the protective effects of L-Cys on A549 cells against oxidative damage by acetaldehyde were dose-dependent within the range of 10  μ mol/L to 160  μ mol/L. Acetaldehyde damaged the mitochondria and resulted in the apoptosis of A549 cells by reactive oxygen species (ROS), e.g., free radicals, but L-Cys reversed the release of cytochrome c from the mitochondria, reduced the rate of apoptosis, and protected cells from ROS and oxidative stress.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2018/6864574
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 4
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    Risk Factors and Nursing Countermeasures of Ventilator-Associated Pneumonia in Children in the Intensive Care Unit
    Hindawi Limited ; 2022
    In:  Journal of Healthcare Engineering Vol. 2022 ( 2022-2-17), p. 1-6
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2022 ( 2022-2-17), p. 1-6
    Abstract: Objective. This study discussed and analyzed the risk factors and nursing countermeasures of ventilator-associated pneumonia (VAP) in the children intensive care unit (ICU). Methods. In this study, 155 children with mechanical ventilation in the pediatric intensive care unit from Oct. 2018 to Oct. 2020 were chosen as research objects. We retrospectively analyzed the clinical data of children and divided them into VAP groups and non-VAP groups according to the occurrence of VAP. Subsequently, we adopted a univariate and multivariate logistic regression model to analyze and clarify the risk factors of VAP and formulated the corresponding nursing countermeasures. Results. 49 cases of total research objects had occurred VAP, with an infection rate of 31.62%. The primary pathogenic bacteria were Gram-negative bacteria (43/70, 61.43%). According to multivariate logistic regression analysis, the duration of mechanical ventilation, invasive procedures, and application of hormones and antacids are all independent risk factors for VAP in pediatric ICU. The VPA group had longer hospital stay than the non-VAP group, and the difference was statistically significant ((20.92 ± 4.16)d, (15.24 ± 3.77)d, t = 8.4383, P  ≤ 0.001). The hospitalization cost of the VPA group was substantially higher than that of the non-VAP Group ((45.8 ± 10.4) thousand Yuan, (33.2 ± 4.3) thousand Yuan, t = 10.6822, P  ≤ 0.001). Conclusion. Children admitted to the pediatric ICU have a high VAP incidence. The primary pathogenic bacteria are Gram-negative bacteria. As the occurrence of VAP is closely related to a variety of factors, we should take targeted nursing countermeasures to reduce the duration of mechanical ventilation and the frequency of invasive operations and use the hormone and antacids rationally to reduce the risk of VAP and improve the prognosis.
    Type of Medium: Online Resource
    ISSN: 2040-2309 , 2040-2295
    URL: Article
    DOI: 10.1155/2022/9055587
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2545054-2
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  • 5
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    The Effect of Psychological Support Intervention Based on Structure-Process-Result Three-Dimensional Quality Assessment on Maternal Role Adaptation and Pelvic Floor Rehabilitation Exercise Compliance of Women in Spontaneous Labor
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-5-27), p. 1-9
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-5-27), p. 1-9
    Abstract: Objective. A case-control study was conducted to explore the effect of psychological support intervention based on structure-process-result three-dimensional quality assessment on maternal role adaptation and pelvic floor rehabilitation exercise compliance. Methods. 110 parturients who delivered naturally in our hospital from January 2019 to October 2021 were randomly divided into the control group and the study group. Patients in the former group received routine nursing measures, while patients in the latter group received psychological support intervention based on structure-process-outcome three-dimensional quality assessment (intervention group). Psychological intervention measures include health education, cognitive therapy, behavioral therapy, collective psychological intervention, and happiness therapy. The Edinburgh postpartum depression (PPD) scale and general self-efficacy scale were adopted before intervention, on the day of discharge, and 42 days after delivery. Meanwhile, the mother’s role adaptation questionnaire was adopted 42 days after delivery. The PPD, the change of self-efficacy, the function of the pelvic floor, the role adaptation of mothers, and the compliance of pelvic floor rehabilitation exercise in the control group and the intervention group were analyzed. Results. There was a significant difference in the EPDS score between the two groups at 42 days after delivery. There was a significant difference in the incidence of depression 42 days after delivery between the two groups ( P 〈 0.05 ). The score of pelvic floor function in the two groups after intervention was higher than that before intervention, and that in the intervention group was higher than that in the control group ( P 〈 0.05 ). The score of self-efficacy in the two groups after intervention was higher than that before intervention, and that in the intervention group was higher than that in the control group ( P 〈 0.05 ). The role adaptation of mothers in the intervention group was better than that in the control group ( P 〈 0.05 ). The compliance rate of pelvic floor rehabilitation exercise in the intervention group was higher than that in the control group ( P 〈 0.05 ). Conclusion. Psychological support intervention based on structure-process-result three-dimensional quality assessment can effectively enhance the sense of self-efficacy, pelvic floor function, maternal role adaptation, and pelvic floor rehabilitation exercise compliance of parturients and can effectively reduce the incidence of PPD and play a positive role in the prevention of PPD.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/8993144
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 6
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    Construction of a Clinical Predictive Model of Left Atrial and Left Atrial Appendage Thrombi in Patients with Nonvalvular Atrial Fibrillation
    Hindawi Limited ; 2022
    In:  Journal of Interventional Cardiology Vol. 2022 ( 2022-11-4), p. 1-8
    Details
    In: Journal of Interventional Cardiology, Hindawi Limited, Vol. 2022 ( 2022-11-4), p. 1-8
    Abstract: Background. The purpose of this study was to investigate the risk factors of left atrial (LA) or left atrial appendage (LAA) thrombi in patients with nonvalvular atrial fibrillation (NVAF) and to establish and validate relevant predictive models. It might improve thromboembolic risk stratification in patients with NVAF. Methods. This study retrospectively included 1210 consecutive patients with NVAF undergoing transesophageal echocardiography (TEE), of whom 139 patients had thrombi in LA or in LAA. Through literature review and the ten events per variable (10EPV) principle, 13 variables were finally identified for inclusion in multivariate analysis. Models were constructed by multivariate logistic stepwise regression and least absolute shrinkage and selection operator (lasso) regression. Results. After logistic regression, five variables (AF type, age, B-type natriuretic peptide, E/e’ ratio, and left atrial diameter) were finally screened out as model 1. After Lasso regression, AF type, age, gender, B-type natriuretic peptide, E/e’ ratio, left atrial diameter, and left ventricular ejection fraction were finally screened as model 2. After comparing the two models, the simpler model 1 was finally selected. The area under the ROC curve (AUC) of the model 1 was 0.865 (95% CI: 0.838–0.892), the Hosmer–Lemeshow test = 0.898, and the AUC = 0.861 after internal validation. The clinical decision curve showed that the new clinical prediction model could achieve a net clinical benefit when the expected threshold was between 0 and 0.6. Conclusion. This study constructed a new clinical prediction model of LA or LAA thrombi, with a higher discriminative degree than the CHADS2 and CHA2DS2-VASc scoring systems (AUC: 0.865 vs. 0.643; AUC: 0.865 vs 0.652).
    Type of Medium: Online Resource
    ISSN: 1540-8183 , 0896-4327
    URL: Article
    DOI: 10.1155/2022/7806027
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2103585-4
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  • 7
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    The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture
    Hindawi Limited ; 2020
    In:  Pain Research and Management Vol. 2020 ( 2020-03-26), p. 1-10
    Details
    In: Pain Research and Management, Hindawi Limited, Vol. 2020 ( 2020-03-26), p. 1-10
    Abstract: Objective . The aim of this study was to demonstrate the peripheral mechanisms of chrono-acupuncture by observing acupuncture at different time points affecting relative proteins to regulate the cytoskeleton of fibroblasts differently. Methods . A total of 108 male SD rats (180–220 g) that have basic pain threshold within 3–10 s were selected and randomly divided into group A ( n  = 72) and control group ( n  = 36). After the succession of modeling with CFA injection, the rats in group A were randomly divided into model group and acupuncture group, each group containing 36 rats. Then according to the different treatment time, each group was randomly classified into 6 subgroups (ZT0, ZT4, ZT8, ZT12, ZT16, and ZT20), each subgroup containing 6 rats ( n  = 6). On the second day of successful modeling, the rats in the acupuncture group received acupuncture treatment at the corresponding time point, while the control group and the model group were only tied up at the corresponding time point without any treatments. Methods of operation: use 0.5-inch needles, puncture the rats’ “Zusanli” on the affected limb, with Twirling manipulation for a minute after every five minutes; the treatment lasts thirty minutes in total. After 7 days of treatments, the skin and subcutaneous tissue of rats’ acupoint area of “Zusanli” on the affected limb were taken and then stained by immunofluorescence double staining method to observe the expression of the fibroblast cytoskeleton F-actin and β -tubulin under the LSCM while using western blot to observe the expression of P38MAPK/P-P38MAPK. Results . The expression of the cytoskeleton F-actin and β -tubulin at acupoint area in the acupuncture group was significantly higher than that in the control and model group. The effect of acupuncture on the restructure of the fibroblast cytoskeleton is different at different time points, the most effective time point was at ZT12 while the least at ZT16. Acupuncture can decrease the high expression of P-P38MAPK/P38MAPK in the model group, and the effect has time differences. The expression of P-P38MAPK/P38MAPK increased more significantly at ZT16 than ZT12. Conclusion . The remodeling difference of fibroblast cytoskeleton after receiving acupuncture treatment could be one of the peripheral bases of the chrono-acupuncture.
    Type of Medium: Online Resource
    ISSN: 1203-6765 , 1918-1523
    URL: Article
    DOI: 10.1155/2020/3731510
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2048409-4
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  • 8
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    Cost-Effective and Ultraportable Smartphone-Based Vision System for Structural Deflection Monitoring
    Hindawi Limited ; 2021
    In:  Journal of Sensors Vol. 2021 ( 2021-4-2), p. 1-12
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2021 ( 2021-4-2), p. 1-12
    Abstract: This work demonstrates the viability of using a smartphone-based vision system to monitor the deflection of engineering structures subjected to external loadings. The video images of a test structure recorded by a smartphone camera are processed using the state-of-the-art subset-based digital image correlation (DIC) algorithm to extract the vertical image displacement of discrete calculation points defined on the test object. The measured vertical image displacement can be converted to deflection (vertical displacement) by easy-to-implement scaling factor determination approaches. For accuracy validation, laboratory experiments using a cantilever beam subjected to external loadings were performed. The deflection and inherent frequency of the test cantilever beam measured by the proposed smartphone-based vision system were compared with those measured by conventional dial gauges and a dynamic strain gauge. The relative errors were estimated as 1% and 0.15% for deflection and inherent frequency, respectively. Outdoor real bridge deflection monitoring tests were also carried out on an overpass with subway passing by, and the measured deflection-time curves agree well with actual situations. The cost-effective, ultraportable, and easy-to-use smartphone-based vision system not only greatly decreases the hardware investment and complexity in deflection measurement system construction, but also increases the convenience and efficiency of deflection monitoring of engineering structures.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    URL: Article
    DOI: 10.1155/2021/8843857
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2397931-8
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  • 9
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    Permanence and Extinction for a Nonautonomous Malaria Transmission Model with Distributed Time Delay
    Hindawi Limited ; 2014
    In:  Journal of Applied Mathematics Vol. 2014 ( 2014), p. 1-15
    Details
    In: Journal of Applied Mathematics, Hindawi Limited, Vol. 2014 ( 2014), p. 1-15
    Abstract: We study the permanence, extinction, and global asymptotic stability for a nonautonomous malaria transmission model with distributed time delay. We establish some sufficient conditions on the permanence and extinction of the disease by using inequality analytical techniques. By a Lyapunov functional method, we also obtain some sufficient conditions for global asymptotic stability of this model. A numerical analysis is given to explain the analytical findings.
    Type of Medium: Online Resource
    ISSN: 1110-757X , 1687-0042
    URL: Article
    DOI: 10.1155/2014/139046
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2578385-3
    SSG: 17,1
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  • 10
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    Stability Analysis and Design of Time-Varying Nonlinear Systems Based on Impulsive Fuzzy Model
    Hindawi Limited ; 2012
    In:  Discrete Dynamics in Nature and Society Vol. 2012 ( 2012), p. 1-16
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2012 ( 2012), p. 1-16
    Abstract: This paper develops a general analysis and design theory for nonlinear time-varying systems represented by impulsive T-S fuzzy control model, which extends conventional T-S fuzzy model. In the proposed, model impulse is viewed as control input of T-S model, and impulsive distance is the major controller to be designed. Several criteria on general stability, asymptotic stability, and exponential stability are established, and a simple design algorithm is provided with stability of nonlinear time-invariant systems. Finally, the numerical simulation for the predator-prey system with functional response and impulsive effects verify the effectiveness of the proposed methods.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2012/192546
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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