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  • Wiley  (5)
  • Zhang, Wei  (5)
  • 1
    Online Resource
    Online Resource
    Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma
    Wiley ; 2019
    In:  Journal of Cellular and Molecular Medicine Vol. 23, No. 6 ( 2019-06), p. 4054-4062
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 23, No. 6 ( 2019-06), p. 4054-4062
    Abstract: Microvesicles (MVs), which are cell‐derived membrane vesicles present in body fluids, are closely associated with the development of malignant tumours. Saliva, one of the most versatile body fluids, is an important source of MVs. However, the association between salivary MVs (SMVs) and oral squamous cell carcinoma (OSCC), which is directly immersed in the salivary milieu, remains unclear. SMVs from 65 patients with OSCC, 21 patients with oral ulcer (OU), and 42 healthy donors were purified, quantified and analysed for their correlations with the clinicopathologic features and prognosis of OSCC patients. The results showed that the level of SMVs was significantly elevated in patients with OSCC compared to healthy donors and OU patients. Meanwhile, the level of SMVs showed close correlations with the lymph node status, and the clinical stage of OSCC patients. Additionally, the ratio of apoptotic to non‐apoptotic SMVs was significantly decreased in OSCC patients with higher pathological grade. Consistently, poorer overall survival was observed in patients with lower ratio of apoptotic to non‐apoptotic SMVs. In conclusion, the elevated level of SMVs is associated with clinicopathologic features and decreased survival in patients with OSCC, suggesting that SMVs are a potential biomarker and/or regulator of the malignant progression of OSCC.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2019.23.issue-6
    DOI: 10.1111/jcmm.14291
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2076114-4
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  • 2
    Online Resource
    Online Resource
    The evaluation of efficacy and safety of sunitinib on EGFR‐TKI pretreated advanced non‐small cell lung cancer patients in C hina
    Wiley ; 2014
    In:  The Clinical Respiratory Journal Vol. 8, No. 2 ( 2014-04), p. 206-212
    Details
    In: The Clinical Respiratory Journal, Wiley, Vol. 8, No. 2 ( 2014-04), p. 206-212
    Abstract: Sunitinib is an oral multitargeted tyrosine kinase inhibitor ( TKI ) exhibiting antiagiogenic and antitumor effects. Objective To evaluate the efficacy and potential toxicity of sunitinib therapy in advanced non‐small cell lung cancer ( NSCLC ) patients in China. Methods From J anuary 2009 to A ugust 2011, 30 patients with stage IV NSCLC , who were pretreated with the epidermal growth factor receptor ( EGFR )‐ TKI s and then received sunitinib, were retrospectively reviewed. Univariate and multivariate C ox proportional hazard regression analysis was performed to determine the potential prognostic risk factors influencing NSCLC survival. Results The median progression‐free survival ( PFS ) and median overall survival ( OS ) of all 30 treated patients was 1.25 months [95% confidence interval ( CI ): 0.90–1.9 months] and 3.40 months (95% CI : 3.00–6.80 months), respectively. C ox regression analysis suggested that E astern C ooperative O ncology G roup ( ECOG ) performance status ( PS ) is predictive of both PFS ( P  = 0.001) and OS ( P   〈  0.001). Common adverse events ( AEs ) included hand‐foot syndrome (53.3%), mucositis (40.0%), rash (36.7%) and diarrhea (33.3%). Conclusion No sign of overall clinical benefits of sunitinib was detected in patients with pretreated EGFR ‐ TKI s. Most patients suffered AE s from mild to moderate severity. ECOG PS is highly associated with PFS and OS rate. Further studies in NSCLC are required to determine whether sunitinib is beneficial nor not.
    Type of Medium: Online Resource
    ISSN: 1752-6981 , 1752-699X
    URL: Issue
    URL: Article
    DOI: 10.1111/crj.2014.8.issue-2
    DOI: 10.1111/crj.12059
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2442214-9
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  • 3
    Online Resource
    Online Resource
    Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non‐small‐cell lung cancer characterizes the features of response to PD‐1 blockade plus chemotherapy
    Wiley ; 2022
    In:  Cancer Communications Vol. 42, No. 12 ( 2022-12), p. 1331-1346
    Details
    In: Cancer Communications, Wiley, Vol. 42, No. 12 ( 2022-12), p. 1331-1346
    Abstract: Although programmed cell death 1 (PD‐1) blockade plus chemotherapy can significantly prolong the progression‐free survival (PFS) and overall survival (OS) in first‐line settings in patients with driver‐negative advanced non‐small‐cell lung cancer (NSCLC), the predictive biomarkers remain undetermined. Here, we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD‐1 blockade plus chemotherapy. Methods Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone. Tumor immune microenvironmental markers, including PD‐1 ligand (PD‐L1), CD8, CD68, CD4 and forkhead box P3, were assessed using multiplex immunofluorescence (mIF) assays. Kaplan‐Meier curves were used to determine treatment outcome differences according to their expression status. Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations. Results Responders had significantly higher CD8/PD‐L1 ( P  = 0.015) or CD68/PD‐L1 co‐expression levels ( P  = 0.021) than non‐responders in the camrelizumab plus chemotherapy group, while no difference was observed in the chemotherapy group. Patients with high CD8/PD‐L1 or CD68/PD‐L1 co‐expression level was associated with significantly longer PFS ( P  = 0.002, P  = 0.024; respectively) and OS ( P  = 0.006, P  = 0.026; respectively) than those with low co‐expression in camrelizumab plus chemotherapy group. When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD‐L1 co‐expression stratification, significantly better PFS ( P  = 0.003) and OS ( P  = 0.032) were observed in high co‐expression subgroups. The predictive value of CD8/PD‐L1 and CD68/PD‐L1 co‐expression remained statistically significant for PFS and OS when adjusting clinicopathological features. Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD‐L1 or CD68/PD‐L1 co‐expression, the positive groups had a significantly higher proportion of TP53 / KRAS co‐mutations than the negative groups (both 13.0% vs. 0.0%, P  = 0.023). Notably, enriched PI3K ( P  = 0.012) and cell cycle pathway ( P  = 0.021) were found in the CD8/PD‐L1 co‐expression group. Conclusion Tumor immune microenvironmental marker expression, especially CD8/PD‐L1 or CD68/PD‐L1 co‐expression, was associated with the efficacy of PD‐1 blockade plus chemotherapy as first‐line treatment in patients with advanced NSCLC.
    Type of Medium: Online Resource
    ISSN: 2523-3548 , 2523-3548
    URL: Issue
    URL: Article
    DOI: 10.1002/cac2.v42.12
    DOI: 10.1002/cac2.12383
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2922913-3
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  • 4
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    Online Resource
    A multicenter retrospective analysis of the clinical and pathological characteristics of 1188 cases of actinic keratosis in different ultraviolet radiation intensity areas of China
    Wiley ; 2022
    In:  Journal of Cosmetic Dermatology Vol. 21, No. 7 ( 2022-07), p. 2879-2888
    Details
    In: Journal of Cosmetic Dermatology, Wiley, Vol. 21, No. 7 ( 2022-07), p. 2879-2888
    Abstract: Actinic keratosis (AK) is a precancerous disease, caused by ultraviolet radiation (UV). Objective To analyze the clinical and pathological characteristics of AK in four areas with different ultraviolet radiation intensities. Methods 1188 diagnosed AK patients, from January 2000 to July 2015, in dermatology department of four hospitals were collected. The UV intensity of hospital located cities from high to low is Kunming, Yinchuan, Shenyang and Nanjing. The information comes from medical records, and the pathological types and Keratinocyte Intraepithelial Neoplasia (KIN) grades were checked by two experienced pathologists. All information was conducted a retrospective multicenter research. Results The patients were mainly middle‐aged and elderly female, which was in direct contrast to the majority of men in European. The age of onset in Kunming group was lower than that in Yinchuan Group ( p  = 0.013) and Nanjing Group ( p  〈  0.01). The course of disease in Kunming group was significantly shorter than that in Nanjing Group ( p  〈  0.001). The lesions were almost located in the exposed area. The proportion of unexposed areas in Shenyang group was significantly higher than that in other groups ( p  〈  0.001). There were statistical differences in pathological morphological classification among the four groups. These differences were not affected by age and gender. The number of KIN III grade patients in Shenyang group was significantly higher than that in other three groups ( p  〈  0.05). Conclusion The Asian patients were mainly female. The clinical characteristics of AK are closely related to UV intensity, and environmental pollution, lifestyle, religious beliefs and other factors are also related.
    Type of Medium: Online Resource
    ISSN: 1473-2130 , 1473-2165
    URL: Issue
    URL: Article
    DOI: 10.1111/jocd.v21.7
    DOI: 10.1111/jocd.14479
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2075528-4
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  • 5
    Online Resource
    Online Resource
    Down‐regulation of connexin43 and connexin32 in keratocystic odontogenic tumours: potential association with clinical features
    Wiley ; 2015
    In:  Histopathology Vol. 66, No. 6 ( 2015-05), p. 798-807
    Details
    In: Histopathology, Wiley, Vol. 66, No. 6 ( 2015-05), p. 798-807
    Abstract: The objective of this study was to explore the potential involvement of connexin43 (Cx43) and connexin32 (Cx32), two vital members of the connexin families, in the pathogenesis of keratocystic odontogenic tumours ( KCOT ). Methods and results The expression levels of Cx43 and Cx32 in human KCOT and normal oral mucosa (OM) tissues were measured using immunohistochemistry and real‐time quantitative polymerase chain reaction ( qPCR ). The relationship between Cx43 and Cx32 expression and markers of proliferation [proliferating cell nuclear antigen (PCNA), cyclin D1], anti‐apoptosis [B cell lymphoma 2 (Bcl‐2)] and autophagy [light chain 3 (LC3), Sequestosome 1 p62 (p62)] was then investigated in the KCOT samples. The results showed that Cx43 and Cx32 expression was down‐regulated significantly in KCOT samples relative to OM samples. Meanwhile, the expression levels of Cx43 and Cx32 were correlated negatively with the expression levels of PCNA, cyclin D1, Bcl‐2, LC3 and p62, as confirmed further by double‐labelling immunofluorescence analyses. Conclusions This study reveals for the first time that Cx43 and Cx32 are down‐regulated in KCOT and suggests an association with growth regulation, anti‐apoptosis and autophagy in KCOT .
    Type of Medium: Online Resource
    ISSN: 0309-0167 , 1365-2559
    URL: Issue
    URL: Article
    DOI: 10.1111/his.2015.66.issue-6
    DOI: 10.1111/his.12569
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2006447-0
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