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  • SAGE Publications  (22)
  • Zhang, Wei  (22)
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  • SAGE Publications  (22)
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  • 1
    Online Resource
    Online Resource
    Clinical characterization and prognostic implications of metabolic syndrome in patients undergoing peritoneal dialysis at a Chinese center
    SAGE Publications ; 2019
    In:  Journal of International Medical Research Vol. 47, No. 11 ( 2019-11), p. 5573-5583
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 47, No. 11 ( 2019-11), p. 5573-5583
    Abstract: Metabolic syndrome (MS) is a common clinical condition associated with cardiovascular disease in patients undergoing peritoneal dialysis (PD); however, its prognostic implication among patients receiving PD remains controversial. Methods In a prospective study from January 2013 and June 2016, we enrolled 190 patients undergoing PD and followed them for 46.4 ± 30.7 months. We assessed the associations of clinical characteristics and measurements with diabetes mellitus (DM) status, MS, and prognostic outcomes among the included patients. Results We found that DM was associated with shortened duration of dialysis and poor survival. The prevalence of MS was 58.9% among all patients. We found significant differences in age, body weight, body mass index, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, leukocytes, platelets, neutrophil percentage, and pre-albumin between patients with and without MS. We found a negative correlation trend between serum intact parathyroid hormone and MS among our patients. The arteriosclerosis index was significantly elevated in the MS group compared with the non-MS group. Serum calcium concentration and frequency of hospital admissions were significantly associated with mortality and technique failure. Conclusions MS was positively associated with cardiovascular disease. DM, and hypocalcemia. Frequent hospital admissions can predict poor prognosis in patients undergoing PD.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519875335
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Association study of matrix metalloproteinase 3 5A/6A polymorphism with in-stent restenosis after percutaneous coronary interventions in a Han Chinese population
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 1 ( 2020-01), p. 030006051982714-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 1 ( 2020-01), p. 030006051982714-
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519827145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    Integrative analyses reveal RNA regulatory network in Ti particles induced inflammation
    SAGE Publications ; 2021
    In:  European Journal of Inflammation Vol. 19 ( 2021-01), p. 205873922110448-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 19 ( 2021-01), p. 205873922110448-
    Abstract: Introduction Wear particles induced inflammatory osteolysis is the most important initiating factors in the mechanism of aseptic loosening. However, the molecular network changes in this process remain largely elusive. Methods Here, we performed whole transcriptome analysis using Ti particles induced RAW264.7 cell model to identify specific genes and pathways. Results Sequencing results totally identified 159 mRNAs, 96 lncRNAs, 31 circRNAs, and 12 miRNAs were significantly differently expressed. Of these, we selected two of each RNA for qRT-PCR validation and the results were highly consistent with the RNA-seq data. GSEA analysis shows that upregulated gene sets were related to the three classical inflammation pathway, cytokine–cytokine receptor interaction, TNF, and NF-kappa B signaling pathway. The enriched genes included not only IL-1β and TNF- α, which were independently verified before sequencing, but also other inflammatory osteolysis-related genes such as Mmp9, Fas, and Ccl2. Co-differentially expressed RNAs were employed to construct the ceRNA co-regulatory network. Conclusion: The results revealed that 4 lncRNAs and 2 circRNAs formed a regulatory network to simultaneously regulate miR-3065-3p targeting Myo18a. The present study helps to comprehensively understand the molecular mechanisms and regulatory interaction networks during early inflammatory response.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/20587392211044863
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2584683-8
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  • 4
    Online Resource
    Online Resource
    Claudin-7 Inhibits Proliferation and Metastasis in Salivary Adenoid Cystic Carcinoma Through Wnt/β-Catenin Signaling
    SAGE Publications ; 2020
    In:  Cell Transplantation Vol. 29 ( 2020-01-01), p. 096368972094358-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 29 ( 2020-01-01), p. 096368972094358-
    Abstract: The aim of this study was to investigate claudin-7 (CLDN7) expression in salivary adenoid cystic carcinoma (SACC) and its function in SACC cells. We determined CLDN7 expression in SACC tumors via immunohistochemistry and western blotting and evaluated the association between CLDN7 expression and clinicopathologic variables. Besides this, we constructed a stably transfected CLDN7 knockdown SACC-LM cell line via RNAi and assessed its biological behavior changes (cell viability, migration, and invasion). The correlation between CLDN7 and epithelial-mesenchymal transition (EMT) was analyzed. Additionally, a subcutaneous tumor formation model was used to assess SACC-LM cells tumorigenicity after the CLDN7 knockdown. In the present study, we found the CLDN7 expression of tumor group was lower than that in normal salivary glands and was significantly correlated with lymph node metastasis, recurrence, and gender. CLDN7 knockdown could add the proliferation and metastasis ability of SACC by regulating EMT through Wnt/β-catenin signaling pathway. In addition, CLDN7 knockdown in SACC promoted tumor growth in nude mice. CLDN7 inhibits cell proliferation and metastasis by inactivating the Wnt/β-catenin signaling in SACC. Thus, CLDN7 expression might be a useful marker to identify the potential for progression in SACC.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689720943583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020466-8
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  • 5
    Online Resource
    Online Resource
    Simple method for constructing and repairing tissue microarrays using simple equipment
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 3 ( 2021-03), p. 030006052110001-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 3 ( 2021-03), p. 030006052110001-
    Abstract: Many methods for tissue microarray (TMA) construction were described in previous reports. Because TMA-based methods are expensive and complicated, their widespread application may be restricted. This study aimed to develop a simple method for TMA construction. Methods High-density TMAs were constructed using simple equipment, and hematoxylin and eosin and immunohistochemical staining were performed to analyze the effect on the TMA block. Results A recipient block with 162 holes of 0.9 mm in diameter was prepared using a mini-drill and plastic mold. Tissue cores of 1.0 mm in diameter were obtained from multiple donor blocks with stainless-steel capillary tubes driven by the mini-drill. Under the fixation and guidance of the plastic mold, tissue cores could be easily injected into the holes in the recipient block by inserting a stainless-steel wire into the stainless-steel tube with the tissue core and then pressing using the stainless-steel wire. Conclusion A high-density TMA block with 162 1.0-mm cores was created. This new modified technique could be a good alternative in many laboratories.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211000156
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 6
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    Online Resource
    Controlling Hypertension After Severe Cerebrovascular Event (CHASE): A randomized, multicenter, controlled study
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 4 ( 2021-06), p. 456-465
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 4 ( 2021-06), p. 456-465
    Abstract: The optimal blood pressure lowering target in the acute phase of severe stroke is uncertain. Our aim was to compare the efficacy and safety of individualized blood pressure lowering with standard blood pressure lowering in severe stroke. Methods Five-hundred consecutive patients with acute severe stroke and elevated BP were recruited from 26 Chinese hospitals. Eligible patients were randomized into an individualized blood pressure lowering group (with 10–15% reduction in systolic blood pressure from admission level or standard blood pressure lowering group (with a target SBP of 〈 200 mm Hg in acute ischemic stroke and 〈 180 mm Hg in intracerebral hemorrhage). The primary outcome was the proportion of patients with a poor functional outcome at day 90 of enrolment. Results Of 483 participants included in the analysis, 242 received individualized blood pressure lowering treatment and 241 received standard treatment. The primary outcome event was observed in 71.1% of the participants in the individualized treatment group and in 73.4% of the standard treatment group (odds ratio with individualized treatment for primary outcome, 0.75; 95% confidence interval, 0.47 to 1.19; p = 0.222). The rates of serious adverse events in the two groups were similar (27.7% vs. 28.2%). Conclusions In patients with acute severe stoke, individualized blood pressure lowering treatment did not significantly reduce the rate of three-month death or dependence. Trial registration Clinicaltrials.gov, NCT02982655. Registered in 5 December 2016, https://clinicaltrials.gov/ct2/show/NCT02982655
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493020932784
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 7
    Online Resource
    Online Resource
    From Strength-Based Parenting to Subjective Well-Being of College Students: A Chain Mediating Role of Personal Growth Initiative and Strengths Use
    SAGE Publications ; 2023
    In:  Psychological Reports
    Details
    In: Psychological Reports, SAGE Publications
    Abstract: Previous research demonstrated a positive relationship between strength-based parenting (SBP) and subjective well-being (SWB). However, the underlying mechanisms still need further research. Based on the social cognitive theory and developmental assets framework, we investigated the influence of SBP on college students’ SWB through the mediating role of personal growth initiative (PGI) and strengths use. A total of 621 Chinese college students were recruited. Participants completed self-report scales about the SBP, PGI, strengths use and SWB. The results showed that SBP had a positive impact on college students’ SWB. On the one hand, PGI and strengths use mediated the above relationship respectively. On the other hand, SBP influenced SWB through the chain mediating effect of PGI and strengths use. The findings indicate that exploring the relationship between SBP and SWB has positive implications for family education and youth development.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.1177/00332941231181656
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 8
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    Neofipiperzine D, A New Prenylated Indole Alkaloid metabolite of the Fungus Neosartorya Fischeri
    SAGE Publications ; 2014
    In:  Journal of Chemical Research Vol. 38, No. 9 ( 2014-09), p. 539-541
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 38, No. 9 ( 2014-09), p. 539-541
    Abstract: A new prenylated indole alkaloid, neofipiperzine D, was isolated from the cultures of Neosartorya fischeri, together with three known metabolites fumitremorgin C, ergosterol, and ergosterol peroxide. The structure of the new compound was established by detailed analysis of its spectroscopic data, especially 1D, 2D NMR and HR-ESI-MS data. In an in vitro assay, neofipiperzine D did not exhibit any significant cytotoxicity against MCF-7, H1299, HUVEC, and MDA-MB-231 cell lines at a concentration of 20 μM.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751914X14097355956467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 3010810-X
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  • 9
    Online Resource
    Online Resource
    Effects of Ginkgo biloba Extract Ingestion on the Pharmacokinetics of Talinolol in Healthy Chinese Volunteers
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 5 ( 2009-05), p. 944-949
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 5 ( 2009-05), p. 944-949
    Abstract: Ginkgo biloba extract (GBE), the best selling herbal medicine in the world, has been reported to inhibit P-glycoprotein in vitro. However, the effects of GBE on P-glycoprotein activity in humans have not been clarified. Objective To investigate the effects of single and repeated GBE ingestion on the oral pharmacokinetics of talinolol, a substrate drug for P-glycoprotein in humans. Methods Ten unrelated healthy male volunteers were selected to participate in a 3-stage sequential study. Plasma concentrations of talinolol from 0 to 24 hours were measured by high-performance liquid chromatography after talinolol 100 mg was administrated alone, with a single oral dose of GBE (120 mg), and after 14 days of repeated GBE ingestion (360 mg/day). Results A single oral dose of GBE did not affect the pharmacokinetics of talinolol. Repeated ingestion of GBE increased the talinolol maximum plasma concentration (C max ) by 36% (90% CI 10 to 68; p = 0.025), the area under the concentration-time curve (AUC) 0-24 by 26% (90% CI 11 to 43; p = 0.008) and AUC 0-∞ by 22% (90% CI 8 to 37; p = 0.014), respectively, without significant changes in elimination half-life and the time to C max . Conclusions Our results suggest that long-term use of GBE significantly influenced talinolol disposition in humans, likely by affecting the activity of P-glycoprotein and/or other drug transporters.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1L656
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 10
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    Online Resource
    Visual assessment and quantitative analysis of bone marrow edema in young and middle-aged versus elderly patients with vertebral compression fracture by spectral CT
    SAGE Publications ; 2022
    In:  Acta Radiologica
    Details
    In: Acta Radiologica, SAGE Publications
    Abstract: For the diagnosis of bone marrow edema (BME), spectral computed tomography (CT) has emerged as a promising technique. Purpose To study the different performances of spectral CT in the diagnosis of vertebral BME in young and middle-aged versus elderly patients. Material and Methods Magnetic resonance imaging (MRI) was used as the gold standard. To determine the existence of BME, spectral CT color-coded images of the vertebral bodies of 82 patients with vertebral compression fractures (VCFs) were visually inspected. A quantitative analysis of the spectral CT vertebral water concentration in the diagnosis of BME was performed using a receiver operating characteristic (ROC) curve. Patients were divided into two groups for comparison: the young and middle-aged group; and the elderly group. Results The sensitivity and specificity for visual assessment were 83.7% and 98.3%, respectively, in the young and middle-aged group and 96.8% and 98.2%, respectively, in the elderly group. The elderly group had a higher sensitivity than the young and middle-aged group ( P  〈  0.05). With a threshold of 1046.2 mg/cm 3 , the ROC curve for the young and middle-aged group displayed an area under the curve (AUC) of 0.870, sensitivity of 86.0%, and specificity of 81.4%. The threshold of 1031.4 mg/cm 3 yielded a sensitivity of 95.2% and a specificity of 98.4%, and the AUC of the elderly group was 0.997. The elderly group had a higher level of specificity than the young and middle-aged group ( P  〈  0.05). Conclusion Spectral CT can reliably diagnose BME in VCFs, and it performs better in elderly people than in young and middle-aged people.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851221146977
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024579-8
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