In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 46, No. 9 ( 2022), p. 4314-4324
Abstract:
Four organotin( iv ) complexes, [(Me 2 Sn) 4 O 2 (C 16 H 17 FN 3 O 3 ) 4 ] (1), [Ph 2 Sn(C 16 H 17 FN 3 O 3 ) 2 ] (2), [(Me 2 Sn) 4 O 2 (C 18 H 19 FN 3 O 4 ) 4 ] (3), and [Ph 2 Sn(C 18 H 19 FN 3 O 4 ) 2 ] (4), have been synthesized via the reaction of R 2 SnO (R = Me, and Ph) with the corresponding ligands [HL 1 = C 16 H 18 FN 3 O 3 , norfloxacin; and HL 2 = C 18 H 20 FN 3 O 4 , levofloxacin]. The four complexes were characterized via elemental analysis, FT-IR, NMR ( 1 H, 13 C and 119 Sn), as well as through single crystal X-ray diffraction analysis. Crystal structure results disclosed that complexes 1 and 3 represent tetranuclear tin monomers, which exist as a ladder-like structure containing a tetraorganodistannoxane unit and four deprotonated ligands. Complexes 2 and 4 represented mononuclear tin monomers. Further C–H⋯F non-covalent intermolecular contacts form 1D chain structures for complex 1. The C–H⋯N and N–H⋯O intermolecular contacts construct 2D planar supramolecular structures for complex 2. The C–H⋯O intermolecular contacts form 2D planar supramolecular structures and 1D chain structures for complexes 3 and 4, respectively. Furthermore, complexes 1–4 were evaluated for their in vitro cytostatic activity against the human cervical carcinoma (HeLa) cell line, the human hepatocellular carcinoma (HepG-2) cell line and normal human colon cells (NCM460). The results indicated that complexes 2 and 4 displayed a high in vitro cytostatic activity. Meanwhile, four phytopathogenic fungi were used in antifungal activity screening for complexes 2 and 4. The study confirmed that complexes 2 and 4 exhibited good antifungal activity. Furthermore, morphological and ultrastructural studies were carried out on the fungi affected by complex 2, and the results indicated that complex 2 may act on the vacuoles of cells and ultimately lead to cell death.
Type of Medium:
Online Resource
ISSN:
1144-0546
,
1369-9261
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472933-7
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