GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (203)
  • Zhang, Meng  (203)
Material
Publisher
  • Wiley  (203)
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Front Cover: Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16 (Chem. Biodiversity 11/2023)
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 11 ( 2023-11)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.11
    DOI: 10.1002/cbdv.202301749
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2139001-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 11 ( 2023-11)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
    Abstract: One new alkaloid, ( S )‐2‐acetamido‐4‐(2‐(methylamino)phenyl)‐4‐oxobutanoic acid ( 1 ), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with 25 known compounds including ten polyketones ( 2–11 ), eight alkaloids ( 12–19 ), six steroids ( 20–25 ), and a fatty acid ( 26 ). Their planar and relative structures were determined by an analysis of 1D and 2D nuclear magnetic resonance (NMR) as well as high resolution electrospray ionization mass spectroscopy (HR‐ESI‐MS) data. The absolute configuration of 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Penicitrinol B ( 6 ) significantly inhibited RSL3‐induced ferroptosis (EC 50 =2.0 μM) by reducing lipid peroxidation and heme oxygenase 1 (HMOX1) expression. Under the concentration of 10 μM, penicitrinol A ( 7 ) was able to inhibit cuproptosis with the cell viabilities of 68.2 % compared to the negative control (copper and elesclomol) with the cell viabilities of 14.8 %.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.11
    DOI: 10.1002/cbdv.202301507
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2139001-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Liquid biopsy: circulating tumor DNA monitors neoadjuvant chemotherapy response and prognosis in stage II / III gastric cancer
    Wiley ; 2023
    In:  Molecular Oncology Vol. 17, No. 9 ( 2023-09), p. 1930-1942
    Details
    In: Molecular Oncology, Wiley, Vol. 17, No. 9 ( 2023-09), p. 1930-1942
    Abstract: A good response to neoadjuvant chemotherapy (NACT) is strongly associated with a higher curative resection rate and favorable outcomes for patients with gastric cancer (GC). We examined the utility of serial circulating tumor DNA (ctDNA) testing for monitoring NACT response and prognosis in stage II–III GC. Seventy‐nine patients were enrolled to receive two cycles of NACT following gastrectomy with D2‐lymphadenectomy. Plasma at baseline, post‐NACT, and after surgery, and tissue at pretreatment and surgery were collected. We used a 425‐gene panel to detect genomic alterations (GAs). Results show that the mean cell‐free DNA concentration of patients with clinical stage III was significantly higher than patients with stage II (15.43 ng·mL −1 vs 14.40 ng·mL −1 ). After receiving NACT and surgery, the overall detection rate of ctDNA gradually reduced (59.5%, 50.8%, and 47.4% for baseline, post‐NACT, and postsurgery). The maximum variant allele frequency (max‐VAF) and the number of GAs decreased from 0.50% to 0.08% and from 2.9 to 1.7 after NACT. For patients with a partial response after NACT, the max‐VAF and the number of GAs declined significantly, but they increased for patients with progressive disease. Patients with detectable ctDNA at baseline, after NACT, or after surgery have a worse overall survival (OS) than patients with undetectable ctDNA. The estimated 3‐year OS was 73% for the post‐NACT ctDNA‐negative patients and 34% for ctDNA‐positive. Patients with perpetual negative ctDNA before and after NACT have the best prognosis. In conclusion, ctDNA was proposed as a potential biomarker to predict prognosis and monitor the NACT response for stage II–III GC patients.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.v17.9
    DOI: 10.1002/1878-0261.13481
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2322586-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    A High‐Energy Density Asymmetric Supercapacitor Based on Fe 2 O 3 Nanoneedle Arrays and NiCo 2 O 4 /Ni(OH) 2 Hybrid Nanosheet Arrays Grown on SiC Nanowire Networks as Free‐Standing Advanced Electrodes
    Wiley ; 2018
    In:  Advanced Energy Materials Vol. 8, No. 12 ( 2018-04)
    Details
    In: Advanced Energy Materials, Wiley, Vol. 8, No. 12 ( 2018-04)
    Abstract: In this paper, a novel freestanding core‐branch negative and positive electrode material through integrating trim aligned Fe 2 O 3 nanoneedle arrays (Fe 2 O 3 NNAs) is first proposed with typical mesoporous structures and NiCo 2 O 4 /Ni(OH) 2 hybrid nanosheet arrays (NiCo 2 O 4 /Ni(OH) 2 HNAs) on SiC nanowire (SiC NW) skeletons with outstanding resistance to oxidation and corrosion, good conductivity, and large‐specific surface area. The original built SiC NWs@Fe 2 O 3 NNAs is validated to be a highly capacitive negative electrode (721 F g −1 at 2 A g −1 , i.e., 1 F cm −2 at 2.8 mA cm −2 ), matching well with the similarly constructed SiC NWs@NiCo 2 O 4 /Ni(OH) 2 HNAs positive electrode (2580 F g −1 at 4 A g −1 , i.e., 3.12 F cm −2 at 4.8 mA cm −2 ). Contributed by the uniquely engineered electrodes, a high‐performance asymmetric supercapacitor (ASC) is developed, which can exhibit a maximum energy density of 103 W h kg −1 at a power density of 3.5 kW kg −1 , even when charging the device within 6.5 s, the energy density can still maintain as high as 45 W h kg −1 at 26.1 kW kg −1 , and the ASC manifests long cycling lifespan with 86.6% capacitance retention even after 5000 cycles. This pioneering work not only offers an attractive strategy for rational construction of high‐performance SiC NW‐based nanostructured electrodes materials, but also provides a fresh route for manufacturing next‐generation high‐energy storage and conversion systems.
    Type of Medium: Online Resource
    ISSN: 1614-6832 , 1614-6840
    URL: Issue
    URL: Article
    DOI: 10.1002/aenm.v8.12
    DOI: 10.1002/aenm.201702787
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2594556-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    High‐resolution magnetic resonance imaging of acute intracranial artery thrombus
    Wiley ; 2023
    In:  European Journal of Neurology Vol. 30, No. 10 ( 2023-10), p. 3172-3181
    Details
    In: European Journal of Neurology, Wiley, Vol. 30, No. 10 ( 2023-10), p. 3172-3181
    Abstract: The development of high‐resolution magnetic resonance imaging (HR‐MRI) has enabled submillimeter‐level evaluation of intracranial artery plaque and luminal thrombus. We sought to investigate the value of HR‐MRI in assessing the pathogenesis of acute intracranial artery thrombus. Methods We examined the presence of intracranial thrombus on three‐dimensional T1‐weighted HR‐MRI in acute ischemic stroke patients with intracranial artery occlusion on magnetic resonance angiography. We defined two thrombus‐related HR‐MRI features (peri‐thrombus plaque and distal residual flow beyond the thrombus) and analyzed their association with potential embolic sources. Results Luminal thrombus and a shrunken artery without luminal thrombus were detected in 162 (96.4%) and six (3.6%) of 168 patients with intracranial artery occlusion, respectively. Among 111 patients with culprit major artery thrombus, peri‐thrombus plaques were observed in 46.8% and distal residual flow beyond the thrombus in 64.0%. Patients with peri‐thrombus plaque had a higher prevalence of diabetes (44.2% vs. 25.4%; p  = 0.037), a lower prevalence of potential sources of cardioembolism (0% vs. 16.9%; p  = 0.002), and a nonsignificantly lower prevalence of potential embolic sources from extracranial arteries (9.6% vs. 20.3%; p  = 0.186) than those without. Patients with distal residual flow beyond the thrombus had a lower prevalence of potential sources of cardioembolism (1.4% vs. 22.5%; p   〈  0.001) and smaller infarct volumes (5.0 [1.4–12.7] mL vs. 16.6 [2.4–94.6]  mL; p  = 0.012) than those without. Conclusions Our study showed that HR‐MRI helps clarify the pathogenesis of acute intracranial artery thrombus. The presence of peri‐thrombus plaque and distal residual flow beyond the thrombus favor the stroke mechanism of atherosclerosis rather than cardioembolism.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v30.10
    DOI: 10.1111/ene.15985
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020241-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 11 ( 2019-09), p. 5000-5011
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 11 ( 2019-09), p. 5000-5011
    Abstract: This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. Methods A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems. Results Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno‐neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC. Conclusions Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v8.11
    DOI: 10.1002/cam4.2370
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury
    Wiley ; 2017
    In:  Journal of Neurochemistry Vol. 141, No. 1 ( 2017-04), p. 137-150
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 141, No. 1 ( 2017-04), p. 137-150
    Abstract: Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of GABA A receptors, which play a vital role in modulating hippocampal functions. Chronic pain is accompanied by increased neurosteroid production in the spinal cord and thalamus. We hypothesize that hippocampal neurosteroids participate in pain or pain‐associated emotions, which we tested with high‐performance liquid chromatography/tandem mass spectrometry and pharmacological behavioral tests. We observed increased levels of hippocampal neurosteroids (pregnenolone, progesterone, deoxycorticosterone, and allopregnanolone) in rats with chronic neuropathic pain (28 days after spared nerve injury). Meanwhile, the expression of the translocator protein, the upstream steroidogenesis rate‐limiting enzyme, increased in the ventral but not dorsal hippocampus of neuropathic rats. In both naïve and neuropathic rats, in vivo stereotaxic microinjection of PK 11195, the translocator protein inhibitor, into the ventral hippocampus exacerbated anxiety‐like behaviors. These results indicate anxiolytic effects of hippocampal neurosteroids in both normal and neuropathic rats. Neurosteroids could be considered as agents for treatment of general and pain‐related anxiety disorders. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.2017.141.issue-1
    DOI: 10.1111/jnc.13965
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020528-4
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Myricitrin promotes osteogenesis and prevents ovariectomy bone mass loss via the PI3K/AKT signalling pathway
    Wiley ; 2023
    In:  Journal of Cellular Biochemistry Vol. 124, No. 8 ( 2023-08), p. 1155-1172
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 124, No. 8 ( 2023-08), p. 1155-1172
    Abstract: This study aimed to explore the effect of myricitrin on osteoblast differentiation in mice immortalised bone marrow mesenchymal stem cells (imBMSCs). Additionally, ovariectomy (OVX) mice were employed to examine the effect of myricitrin on bone trabecular loss in vivo. The effect of myricitrin on the proliferation of imBMSCs was evaluated using a cell counting kit‐8 assay. Alizarin red staining, alkaline phosphatase staining were performed to elucidate osteogenesis. Furthermore, qRT‐PCR and western blot determined the expression of osteo‐specific genes and proteins. To screen for candidate targets, mRNA transcriptome genes were sequenced using bioinformatics analyses. Western blot and molecular docking analysis were used to examine target signalling markers. Moreover, rescue experiments were used to confirm the effect of myricitrin on the osteogenic differentiation of imBMSCs. OVX mice were also used to estimate the delay capability of myricitrin on bone trabecular loss in vivo using western blot, micro‐CT, tartaric acid phosphatase (Trap) staining, haematoxylin and eosin staining, Masson staining and immunochemistry. In vitro, myricitrin significantly enhanced osteo‐specific genes and protein expression and calcium deposition. Moreover, mRNA transcriptome gene sequencing and molecular docking analysis revealed that this enhancement was accompanied by an upregulation of the PI3K/AKT signalling pathway. Furthermore, copanlisib, a PI3K inhibitor, partially reversed the osteogenesis promotion induced by myricitrin. In vivo, western blot, micro‐CT, hematoxylin and eosin staining, Masson staining, Trap staining and immunochemistry revealed that bone trabecular loss rate was significantly alleviated in the myricitrin low‐ and high‐dose groups, with an increased expression of osteopontin, osteoprotegerin, p‐PI3K and p‐AKT compared to the OVX group. Myricitrin enhances imBMSC osteoblast differentiation and attenuate bone mass loss partly through the upregulation of the PI3K/AKT signalling pathway. Thus, myricitrin has therapeutic potential as an antiosteoporosis drug.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v124.8
    DOI: 10.1002/jcb.30439
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479976-5
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Achieving 78.2 % Faraday Efficiency for Electrochemical Ammonia Production Via Covalent Modification of CNTs with B 4 C
    Wiley ; 2024
    In:  ChemCatChem
    Details
    In: ChemCatChem, Wiley
    Abstract: Electrochemical reduction of N 2 to NH 3 provides an alternative to the Haber‐Bosch process for sustainable NH 3 production driven by renewable electricity. Here, we reported carbon nanotubes (CNTs) covalently modified with boron carbide (B 4 C) as a nonmetallic catalyst for efficient electrochemical nitrogen reduction reaction (NRR) under ambient conditions. The structure of the catalyst was characterized by transmission electron microscopy (TEM), X‐ray diffraction (XRD), elemental mapping, X‐ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The catalyst held a superior selectivity for NRR with high Faraday efficiency of 78.2 % accompanying with NH 3 yield rate of 14.0 μg mg −1 cat. h −1 under the condition of 0.1 M Na 2 SO 4 and −0.6 V vs. RHE. Electrochemical experiments including cyclic voltammetry, electrochemical impedance spectroscopy and Tafel polarization curves were performed to explain the best electrochemical properties of B 4 C/CNTs among the samples. This work demonstrates that the strategy of covalent modification plays an important role to improve the selectivity of electrochemical NRR catalyst, thus allowing the reactions to proceed more efficiently.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Article
    DOI: 10.1002/cctc.202400115
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2501161-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis
    Wiley ; 2021
    In:  The Prostate Vol. 81, No. 1 ( 2021-01), p. 29-40
    Details
    In: The Prostate, Wiley, Vol. 81, No. 1 ( 2021-01), p. 29-40
    Abstract: Chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS) is a disease with an unclear pathogenesis. Recent studies have reported that regulatory T (Treg) cells might be involved in the development of CP/CPPS. In this study we aimed to examine the functional role of Treg cells and explore the possible regulatory mechanism of Treg cells in CP/CPPS. Methods An experimental autoimmune prostatitis (EAP) mouse model was constructed; the numbers and functions of Treg cells in the EAP and control groups were tested. Then, cell differentiation experiments were conducted to evaluate the regulatory effect of autophagy on Treg cell differentiation. Furthermore, autologous CD4 + CD25 ‐ cells and CD4 + CD25 + cells from the two groups were magnetically sorted and cocultured to observe differences in cellular inhibitory functions. Finally, in an in vivo experiment, rapamycin was intraperitoneally injected into EAP mice for 4 weeks to observe the therapeutic effects. Results We found that the number and function of Treg cells in the EAP group were diminished compared to those in the control group. Meanwhile, the tolerance of pain in EAP mice had also decreased. Moreover, after using the autophagy activator rapamycin, the expression of the inflammatory cytokines interleukin‐1β was decreased and the pain symptoms were alleviated. A mechanistic study found that autophagy activation promoted the differentiation of Treg and increased the suppressive functions of Treg cells, along with the elevated expression of GATA‐3 and cytotoxic T lymphocyte antigen 4 (CTLA‐4). Furthermore, in vivo administration of the autophagy activator rapamycin had similar effects on recovering the frequency and function of Treg cells as well as the expression of GATA‐3 and CTLA‐4. Conclusion The impaired frequency and function of Treg cells may contribute to the progression of CP/CPPS, and autophagy is a protective mechanism that promotes the differentiation of Treg cells and restores the suppressive functions of Treg cells. Autophagy may be a novel therapeutic option for patients with CP/CPPS.
    Type of Medium: Online Resource
    ISSN: 0270-4137 , 1097-0045
    URL: Issue
    URL: Article
    DOI: 10.1002/pros.v81.1
    DOI: 10.1002/pros.24073
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1494709-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...