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  • Wiley  (52)
  • Zhang, Meng  (52)
  • 2015-2019  (52)
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  • Wiley  (52)
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  • 2015-2019  (52)
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  • 1
    Online Resource
    Online Resource
    Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 11 ( 2019-09), p. 5000-5011
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 11 ( 2019-09), p. 5000-5011
    Abstract: This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. Methods A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems. Results Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno‐neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC. Conclusions Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v8.11
    DOI: 10.1002/cam4.2370
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
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  • 2
    Online Resource
    Online Resource
    A High‐Energy Density Asymmetric Supercapacitor Based on Fe 2 O 3 Nanoneedle Arrays and NiCo 2 O 4 /Ni(OH) 2 Hybrid Nanosheet Arrays Grown on SiC Nanowire Networks as Free‐Standing Advanced Electrodes
    Wiley ; 2018
    In:  Advanced Energy Materials Vol. 8, No. 12 ( 2018-04)
    Details
    In: Advanced Energy Materials, Wiley, Vol. 8, No. 12 ( 2018-04)
    Abstract: In this paper, a novel freestanding core‐branch negative and positive electrode material through integrating trim aligned Fe 2 O 3 nanoneedle arrays (Fe 2 O 3 NNAs) is first proposed with typical mesoporous structures and NiCo 2 O 4 /Ni(OH) 2 hybrid nanosheet arrays (NiCo 2 O 4 /Ni(OH) 2 HNAs) on SiC nanowire (SiC NW) skeletons with outstanding resistance to oxidation and corrosion, good conductivity, and large‐specific surface area. The original built SiC NWs@Fe 2 O 3 NNAs is validated to be a highly capacitive negative electrode (721 F g −1 at 2 A g −1 , i.e., 1 F cm −2 at 2.8 mA cm −2 ), matching well with the similarly constructed SiC NWs@NiCo 2 O 4 /Ni(OH) 2 HNAs positive electrode (2580 F g −1 at 4 A g −1 , i.e., 3.12 F cm −2 at 4.8 mA cm −2 ). Contributed by the uniquely engineered electrodes, a high‐performance asymmetric supercapacitor (ASC) is developed, which can exhibit a maximum energy density of 103 W h kg −1 at a power density of 3.5 kW kg −1 , even when charging the device within 6.5 s, the energy density can still maintain as high as 45 W h kg −1 at 26.1 kW kg −1 , and the ASC manifests long cycling lifespan with 86.6% capacitance retention even after 5000 cycles. This pioneering work not only offers an attractive strategy for rational construction of high‐performance SiC NW‐based nanostructured electrodes materials, but also provides a fresh route for manufacturing next‐generation high‐energy storage and conversion systems.
    Type of Medium: Online Resource
    ISSN: 1614-6832 , 1614-6840
    URL: Issue
    URL: Article
    DOI: 10.1002/aenm.v8.12
    DOI: 10.1002/aenm.201702787
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2594556-7
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  • 3
    Online Resource
    Online Resource
    Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury
    Wiley ; 2017
    In:  Journal of Neurochemistry Vol. 141, No. 1 ( 2017-04), p. 137-150
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 141, No. 1 ( 2017-04), p. 137-150
    Abstract: Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of GABA A receptors, which play a vital role in modulating hippocampal functions. Chronic pain is accompanied by increased neurosteroid production in the spinal cord and thalamus. We hypothesize that hippocampal neurosteroids participate in pain or pain‐associated emotions, which we tested with high‐performance liquid chromatography/tandem mass spectrometry and pharmacological behavioral tests. We observed increased levels of hippocampal neurosteroids (pregnenolone, progesterone, deoxycorticosterone, and allopregnanolone) in rats with chronic neuropathic pain (28 days after spared nerve injury). Meanwhile, the expression of the translocator protein, the upstream steroidogenesis rate‐limiting enzyme, increased in the ventral but not dorsal hippocampus of neuropathic rats. In both naïve and neuropathic rats, in vivo stereotaxic microinjection of PK 11195, the translocator protein inhibitor, into the ventral hippocampus exacerbated anxiety‐like behaviors. These results indicate anxiolytic effects of hippocampal neurosteroids in both normal and neuropathic rats. Neurosteroids could be considered as agents for treatment of general and pain‐related anxiety disorders. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.2017.141.issue-1
    DOI: 10.1111/jnc.13965
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020528-4
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Maternal High‐Sucrose Diet Accelerates Vascular Stiffness in Aged Offspring via Suppressing Ca v 1.2 and Contractile Phenotype of Vascular Smooth Muscle Cells
    Wiley ; 2019
    In:  Molecular Nutrition & Food Research Vol. 63, No. 14 ( 2019-07)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 63, No. 14 ( 2019-07)
    Abstract: The fetal programming in response to over‐nutrition during pregnancy is involved in pathogenesis of cardiovascular diseases later in life. The authors’ previous work reported that prenatal high‐sucrose (HS) diet impaired functions of large‐conductance Ca 2+ ‐activated K + channels (BK) in mesenteric arteries in the adolescent offspring rats. This study determines whether prenatal HS has a long‐term impact on resistance vasculature in the aged offspring rats. Methods and results Pregnant rats are fed with a high‐sucrose diet until delivery. Aged offspring from prenatal HS exhibit elevated fasting insulin level, insulin resistance index, and diastolic pressure. Both pressure‐induced myogenic responses and phenylephrine‐stimulated contraction of mesenteric arteries in HS are weakened. Electrophysiological tests and western blot indicate that BK and L‐type calcium channels (Ca v 1.2) are impaired in HS group. On the other hand, expression of matrix metalloproteinase 2 of mesenteric arteries is reduced in HS group while expression of tissue inhibitors of metalloproteinase is increased, indicating that extra cellular matrix (ECM) is remodeled. Furthermore, expression of α‐smooth muscle actin is decreased, and insulin/insulin receptor/phosphoinositide3‐kinase (PI3K) signaling pathway is downregulated. Conclusion The results suggest that prenatal HS induced stiffness of mesenteric arteries in aged offspring by inhibiting Ca v 1.2 function and PI3K‐associated contractile phenotype of VSMCs.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v63.14
    DOI: 10.1002/mnfr.201900022
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Hyperspectral scanning laser optical tomography
    Wiley ; 2019
    In:  Journal of Biophotonics Vol. 12, No. 4 ( 2019-04)
    Details
    In: Journal of Biophotonics, Wiley, Vol. 12, No. 4 ( 2019-04)
    Abstract: In order to study physical relationships within tissue volumes or even organism‐level systems, the spatial distribution of multiple fluorescent markers needs to be resolved efficiently in three dimensions. Here, rather than acquiring discrete spectral images sequentially using multiple emission filters, a hyperspectral scanning laser optical tomography system is developed to obtain hyperspectral volumetric data sets with 2‐nm spectral resolution of optically transparent mesoscopic (millimeter‐centimeter) specimens. This is achieved by acquiring a series of point‐scanning hyperspectral extended depth of field images at different angles and subsequently tomographically reconstructing the 3D intensity distribution for each wavelength. This technique is demonstrated to provide robust measurements via the comparison of spectral and intensity profiles of fluorescent bead phantoms. Due to its enhanced spectral resolving ability, this technique is also demonstrated to resolve largely overlapping fluorophores, as demonstrated by the 3D fluorescence hyperspectral reconstruction of a dual‐labeled mouse thymus gland sample and the ability to distinguish tumorous and normal tissues of an unlabeled mouse intestine sample.
    Type of Medium: Online Resource
    ISSN: 1864-063X , 1864-0648
    URL: Issue
    URL: Article
    DOI: 10.1002/jbio.2019.12.issue-4
    DOI: 10.1002/jbio.201800221
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2403788-6
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  • 6
    Online Resource
    Online Resource
    Flexible Organic Electronics in Biology: Materials and Devices
    Wiley ; 2015
    In:  Advanced Materials Vol. 27, No. 46 ( 2015-12), p. 7493-7527
    Details
    In: Advanced Materials, Wiley, Vol. 27, No. 46 ( 2015-12), p. 7493-7527
    Abstract: At the convergence of organic electronics and biology, organic bioelectronics attracts great scientific interest. The potential applications of organic semiconductors to reversibly transmit biological signals or stimulate biological tissues inspires many research groups to explore the use of organic electronics in biological systems. Considering the surfaces of movable living tissues being arbitrarily curved at physiological environments, the flexibility of organic bioelectronic devices is of paramount importance in enabling stable and reliable performances by improving the contact and interaction of the devices with biological systems. Significant advances in flexible organic bio­electronics have been achieved in the areas of flexible organic thin film transistors (OTFTs), polymer electrodes, smart textiles, organic electrochemical ion pumps (OEIPs), ion bipolar junction transistors (IBJTs) and chemiresistors. This review will firstly discuss the materials used in flexible organic bioelectronics, which is followed by an overview on various types of flexible organic bioelectronic devices. The versatility of flexible organic bioelectronics promises a bright future for this emerging area.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v27.46
    DOI: 10.1002/adma.201402625
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1474949-X
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  • 7
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    Online Resource
    Solid‐Phase Synthesis Porous Organic Polymer as Precursor for Fe/Fe 3 C‐Embedded Hollow Nanoporous Carbon for Alkaline Oxygen Reduction Reaction
    Wiley ; 2019
    In:  ChemElectroChem Vol. 6, No. 17 ( 2019-09-02), p. 4491-4496
    Details
    In: ChemElectroChem, Wiley, Vol. 6, No. 17 ( 2019-09-02), p. 4491-4496
    Abstract: A series of issues have been caused by the extensive use of volatile and toxic organic solvents in organics and polymers synthesis, i. e., increased production costs and irreversible damage to the environment. Hence, it is necessary to pioneer a synthesis method that is green, safe, and efficient to the sustainable development of society. Herein, a facile and controllable, but rational and effective, in situ solid‐phase synthesis method was developed to prepare a silica‐templated Fe‐phthalocyanine‐based porous organic polymer (POP), which can be further converted into an iron and nitrogen codoped porous carbon (HS‐Phth‐Fe‐900) upon carbonization and template removal. This innovative approach simultaneously provides a means to control the surface features, thereby tuning the catalytic property of obtained materials. The final HS‐Phth‐Fe‐900 with hierarchical pore structure exhibits hollow hemispheric morphology, large pore volume and surface area, significantly improving the mass transfer efficiency and promoting the accessibility of the active sites, achieving a high oxygen reduction reaction (ORR) activity in alkaline media (0.1 M KOH). HS‐Phth‐Fe‐900 presents a competitive half‐wave potential of 0.823 V and limiting current of 4.887 mA/cm 2 (vs. 0.833 V and 5.621 mA cm −2 for Pt/C) far beyond the catalysts prepared free of template (Phth‐Fe‐900). Furthermore, it also exhibits long‐time stability and methanol immunity surpassing the benchmark Pt/C in 0.1 M KOH. These results may open up new possibilities for the rational design and large‐scale preparation of POPs‐derived materials for electrochemical applications.
    Type of Medium: Online Resource
    ISSN: 2196-0216 , 2196-0216
    URL: Issue
    URL: Article
    DOI: 10.1002/celc.v6.17
    DOI: 10.1002/celc.201901209
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2724978-5
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  • 8
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    Online Resource
    Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC ‐1β: In vivo and in vitro studies
    Wiley ; 2017
    In:  Journal of Pineal Research Vol. 63, No. 3 ( 2017-10)
    Details
    In: Journal of Pineal Research, Wiley, Vol. 63, No. 3 ( 2017-10)
    Abstract: Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. However, its role against pressure overload‐induced cardiac hypertrophy and the underlying mechanisms remains elusive. In this study, we investigated the pharmacological effects of melatonin on pathological cardiac hypertrophy induced by transverse aortic constriction ( TAC ). Male C57 BL /6 mice underwent TAC or sham surgery at day 0 and were then treated with melatonin (20 mg/kg/day, via drinking water) for 4 or 8 weeks. The 8‐week survival rate following TAC surgery was significantly increased by melatonin. Melatonin treatment for 8 weeks markedly ameliorated cardiac hypertrophy. Compared with the TAC group, melatonin treatment for both 4 and 8 weeks reduced pulmonary congestion, upregulated the expression level of α‐myosin heavy chain, downregulated the expression level of β‐myosin heavy chain and atrial natriuretic peptide, and attenuated the degree of cardiac fibrosis. In addition, melatonin treatment slowed the deterioration of cardiac contractile function caused by pressure overload. These effects of melatonin were accompanied by a significant upregulation in the expression of peroxisome proliferator‐activated receptor‐gamma co‐activator‐1 beta ( PGC ‐1β) and the inhibition of oxidative stress. In vitro studies showed that melatonin also protects against angiotensin II ‐induced cardiomyocyte hypertrophy and oxidative stress, which were largely abolished by knocking down the expression of PGC ‐1β using small interfering RNA . In summary, our results demonstrate that melatonin protects against pathological cardiac hypertrophy induced by pressure overload through activating PGC ‐1β.
    Type of Medium: Online Resource
    ISSN: 0742-3098 , 1600-079X
    URL: Issue
    URL: Article
    DOI: 10.1111/jpi.2017.63.issue-3
    DOI: 10.1111/jpi.12433
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2027992-9
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  • 9
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    Online Resource
    Varying 10‐year off‐treatment responses to nucleos(t)ide analogues in patients with chronic hepatitis B according to their pretreatment hepatitis B e antigen status
    Wiley ; 2018
    In:  Journal of Digestive Diseases Vol. 19, No. 9 ( 2018-09), p. 561-571
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 19, No. 9 ( 2018-09), p. 561-571
    Abstract: To evaluate the long‐term durability and efficacy of nucleos(t)ide analogues (NAs) and to determine the related factors for virological relapse in chronic hepatitis B (CHB) patients. METHODS CHB patients who fulfilled the criteria for discontinuing NAs therapy in accordance with the published guidelines were included in the study from December 2001. Virological relapse was defined as serum hepatitis virus B (HBV) DNA 〉 10 4 copies/mL twice at least 2 weeks apart. RESULTS A total of 223 CHB patients were enrolled at the time their NAs therapy was discontinued. The 10‐year cumulative relapse rate (CRR) in hepatitis B e antigen (HBeAg)‐positive patients was statistically lower than that in HBeAg‐negative patients (30.9% vs 62.3%, P 〈 0.001). In the HBeAg‐positive group, Cox regression analysis showed that age at cessation (hazard ratio [HR] 1.067, P 〈 0.001), consolidation therapy (HR 0.958, P = 0.021), and time to HBeAg seroconversion (HR 0.943, P = 0.019) were predictors for relapse. In the HBeAg‐negative group, age at cessation (HR 1.040, P = 0.004) and time to HBV DNA negativity (HR 1.246, P = 0.010) were potential predictors for virological relapse. CONCLUSIONS The off‐treatment responses to NAs differ in CHB patients with different pretreatment HBeAg status. NA withdrawal is generally safe and feasible in young patients with CHB. Long consolidation periods should be preferred in HBeAg‐positive patients to achieve better durability. Benefits of cessation of NAs do not last long in HBeAg‐negative CHB patients.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2018.19.issue-9
    DOI: 10.1111/1751-2980.12654
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2317117-0
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  • 10
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    Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China
    Wiley ; 2018
    In:  Journal of Cellular and Molecular Medicine Vol. 22, No. 7 ( 2018-07), p. 3278-3297
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 7 ( 2018-07), p. 3278-3297
    Abstract: Ganoderma lucidum is an edible medicinal mushroom known as “Lingzhi” in China and “Reishi or Manetake” in Japan. It is a highly prized vitality‐enhancing herb for more than 2000 years. G. lucidum polysaccharide ( GLPS ) has been identified as one of the major bioactive components and developed into a drug named “Ji 731 Injection” in China since 1973. The large‐scale production of the drug began in 1985 and approved by the Chinese FDA as “Polysaccharidum of G. lucidum Karst Injection” (Ling Bao Duo Tang Zhu She Ye) in 2000, which is applied intramuscularly. After more than forty years of clinical use, its efficacy, safety and long‐term tolerability have been recognized by neurologists. It is one of a few non‐hormonal drugs used for treating refractory myopathy. It is also used for combination therapy, which reduces the amount of glucocorticoid required for myopathy patient who is in remission. In addition, it reduces adverse reactions and improves the quality of life for cancer patients during chemotherapy. We found 81 qualified chemical, biochemical, preclinical and clinical studies of GLPS both in English and in Chinese spanning from 1973 to 2017 by searching CNKI (China National Knowledge Infrastructure), Wanfang database and PubMed. The molecular mechanisms underlying GLPS 's antioxidant, anti‐tumour, immune‐modulatory, hypoglycaemic, hypolipidaemic and other activities are discussed. Both preclinical and clinical studies are either deliberated or indexed in the current article. We aimed at providing a molecular picture as well as a clinical basis to comprehend GLPS as one of few polysaccharide‐based modern medicines with complicated chemical and pharmacological properties that prevent it from entering the world's market.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2018.22.issue-7
    DOI: 10.1111/jcmm.13613
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2076114-4
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